EPC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPC1_MOUSE
• UniProt AC: Q8C9X6
• Protein Name: Enhancer of polycomb homolog 1
• Gene Name: Epc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 813
• Subcellular Localization: Nucleus.
• Protein Description: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity)..
• Protein Sequence: MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAISAQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFRMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIKKRKTCRGSSLIPLVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYSGEIMSEVMAQRQPVKPTYAIPIIPITNSSQFKHQDATDSKEFKVNKQDKADLIRPKRKYEKKPKVLPPSAAAPQQQSPAALPGFSAKDLNQYDFPSSDEEPLSQVLSGSSEAEEENDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCLGFARRRVGRGGRVVLDRAHSDYDSMFHHLDLDMLSSPQPSPVNQFANTSEPNTSDRSSSKDLSQILVDIKSCRWRHFRPRTPSLPDSDSGELSSRKLHRSISRAGAAQPGAHTCSTSTQNRSSSGSAHCAFTAEQYQQHQQQLALMQQQQLAQTQQQQQANSSSSAAAQQGFVSKTLDSASAQFAASALMTSEQLLGFKVKDDVVLGLGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSTLLQPSNITQTSGSHSSLSHQVTAASSATTQVLFGNNIRLTVPSSVPTVNSVTPINARHIPRTLSAVPPSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	HHLQRAISAQQVYGE HHHHHHHHHHHHHCC	21.02	27600695
115	Phosphorylation	LDAEQPDYDLDSEDE CCCCCCCCCCCCCCH	25.70	26643407
119	Phosphorylation	QPDYDLDSEDEVFVN CCCCCCCCCCHHHHH	55.00	26745281
294	Acetylation	MAQRQPVKPTYAIPI HHHCCCCCCCEEEEE	38.02	22826441
338	Phosphorylation	LIRPKRKYEKKPKVL HCCCCCCCCCCCCCC	36.69	-
348	Phosphorylation	KPKVLPPSAAAPQQQ CCCCCCCCCCCCCCC	28.71	25293948
356	Phosphorylation	AAAPQQQSPAALPGF CCCCCCCCCCCCCCC	16.51	25266776
364	Phosphorylation	PAALPGFSAKDLNQY CCCCCCCCHHHHCCC	40.08	21454597
419	Phosphorylation	YAPHLDQTGNWPWTS ECCCCCCCCCCCCCC	31.95	26643407
425	Phosphorylation	QTGNWPWTSPKDGGL CCCCCCCCCCCCCCC	30.95	26643407
426	Phosphorylation	TGNWPWTSPKDGGLG CCCCCCCCCCCCCCC	26.53	27600695
486	Phosphorylation	HLDLDMLSSPQPSPV CCCHHHCCCCCCCCC	33.08	25338131
487	Phosphorylation	LDLDMLSSPQPSPVN CCHHHCCCCCCCCCC	24.48	25338131
491	Phosphorylation	MLSSPQPSPVNQFAN HCCCCCCCCCCCCCC	35.91	25338131
532	Phosphorylation	WRHFRPRTPSLPDSD CCCCCCCCCCCCCCC	21.66	21082442
534	Phosphorylation	HFRPRTPSLPDSDSG CCCCCCCCCCCCCCC	52.50	29472430
538	Phosphorylation	RTPSLPDSDSGELSS CCCCCCCCCCCCCCH	31.56	24759943
551	Phosphorylation	SSRKLHRSISRAGAA CHHHHHHHHHHCCCC	17.73	29899451
553	Phosphorylation	RKLHRSISRAGAAQP HHHHHHHHHCCCCCC	19.82	29899451
759	Phosphorylation	RHIPRTLSAVPPSAL HCCCCCCCCCCHHHH	26.97	27600695

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SRF_MOUSE	Srf	physical	19359245
EP300_MOUSE	Ep300	physical	19359245
TRI27_MOUSE	Trim27	physical	11779184
E2F6_HUMAN	E2F6	physical	15536069
TFDP1_MOUSE	Tfdp1	physical	15536069

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.