dbPTM

SRF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRF_MOUSE
UniProt AC	Q9JM73
Protein Name	Serum response factor
Gene Name	Srf
Organism	Mus musculus (Mouse).
Sequence Length	504
Subcellular Localization	Nucleus .
Protein Description	SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS) (By similarity). Required for cardiac differentiation and maturation..
Protein Sequence	MLPSQAGAAAALGRGSALGGNLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGQSRLEREAAAAAAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMELGVVVGGPEAAAAAAGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATGFEEPDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPITNYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAIHVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPTSGLADGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTAPSGTVQIPVSAVQLHQMAVIGQQAGSSSNLTELQVVNLDATHSTKSE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	Phosphorylation	AAAAAAPTAGALYSG HHHHHCCCCHHEECC	32.75	25293948
72	Phosphorylation	APTAGALYSGSEGDS CCCCHHEECCCCCCC	15.51	21183079
73	Phosphorylation	PTAGALYSGSEGDSE CCCHHEECCCCCCCC	36.37	19854140
75	Phosphorylation	AGALYSGSEGDSESG CHHEECCCCCCCCCC	32.25	19854140
79	Phosphorylation	YSGSEGDSESGEEEE ECCCCCCCCCCCHHH	44.51	22817900
81	Phosphorylation	GSEGDSESGEEEELG CCCCCCCCCCHHHHH	56.29	22817900
97	Phosphorylation	ERRGLKRSLSEMELG HHHCHHHHHHHCEEE	34.36	25266776
99	Phosphorylation	RGLKRSLSEMELGVV HCHHHHHHHCEEEEE	35.82	21292826
213	Phosphorylation	TGKALIQTCLNSPDS HHHHHHHHHHCCCCC	16.39	25619855
217	Phosphorylation	LIQTCLNSPDSPPRS HHHHHHCCCCCCCCC	19.69	27087446
220	Phosphorylation	TCLNSPDSPPRSDPT HHHCCCCCCCCCCCC	39.94	27087446
224	Phosphorylation	SPDSPPRSDPTTDQR CCCCCCCCCCCCCCC	54.43	25521595
227	Phosphorylation	SPPRSDPTTDQRMSA CCCCCCCCCCCCHHC	48.25	25619855
228	Phosphorylation	PPRSDPTTDQRMSAT CCCCCCCCCCCHHCC	35.21	27742792
247	Phosphorylation	PDLTYQVSESDSSGE CCCEEEEECCCCCCC	18.83	28833060
249	Phosphorylation	LTYQVSESDSSGETK CEEEEECCCCCCCCC	34.97	28833060
251	Phosphorylation	YQVSESDSSGETKDT EEEECCCCCCCCCCC	49.90	28833060
252	Phosphorylation	QVSESDSSGETKDTL EEECCCCCCCCCCCE	45.71	28833060
255	Phosphorylation	ESDSSGETKDTLKPA CCCCCCCCCCCEECE	37.43	28833060
273	O-linked_Glycosylation	TNLPGTTSTIQTAPS ECCCCCCCEEEECCC	24.29	-
303	O-linked_Glycosylation	TNYLAPVSASVSPSA CCCEEEEEECCCHHH	17.48	-
305	O-linked_Glycosylation	YLAPVSASVSPSAVS CEEEEEECCCHHHHH	18.67	-
312	O-linked_Glycosylation	SVSPSAVSSANGTVL CCCHHHHHCCCCCEE	24.37	-
366	Phosphorylation	HQAPQQASPSRDSST ECCCCCCCCCCCCCC	21.04	21189417
368	Phosphorylation	APQQASPSRDSSTDL CCCCCCCCCCCCCCC	46.34	22802335
379	O-linked_Glycosylation	STDLTQTSSSGTVTL CCCCEECCCCCEEEE	16.82	-
431	Phosphorylation	LTVLNAFSQAPSTMQ EEHHHHHHCCCCEEE	24.03	-
442	Phosphorylation	STMQVSHSQVQEPGG CEEEECHHHCCCCCC	25.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
431	S	Phosphorylation	Kinase	DSDNA KINASE	-	Uniprot
442	S	Phosphorylation	Kinase	DSDNA KINASE	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRF_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EPC1_MOUSE	Epc1	physical	19359245
HOP_MOUSE	Hopx	physical	12297046
BARX2_MOUSE	Barx2	physical	11278942
MYCD_MOUSE	Myocd	physical	11439182

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRF_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220, AND MASSSPECTROMETRY.	19131326 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220, AND MASSSPECTROMETRY.	17242355 [Abstract]