| UniProt ID | ZN649_HUMAN | |
|---|---|---|
| UniProt AC | Q9BS31 | |
| Protein Name | Zinc finger protein 649 | |
| Gene Name | ZNF649 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 505 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways.. | |
| Protein Sequence | MTKAQESLTLEDVAVDFTWEEWQFLSPAQKDLYRDVMLENYSNLVSVGYQAGKPDALTKLEQGEPLWTLEDEIHSPAHPEIEKADDHLQQPLQNQKILKRTGQRYEHGRTLKSYLGLTNQSRRYNRKEPAEFNGDGAFLHDNHEQMPTEIEFPESRKPISTKSQFLKHQQTHNIEKAHECTDCGKAFLKKSQLTEHKRIHTGKKPHVCSLCGKAFYKKYRLTEHERAHRGEKPHGCSLCGKAFYKRYRLTEHERAHKGEKPYGCSECGKAFPRKSELTEHQRIHTGIKPHQCSECGRAFSRKSLLVVHQRTHTGEKPHTCSECGKGFIQKGNLNIHQRTHTGEKPYGCIDCGKAFSQKSCLVAHQRYHTGKTPFVCPECGQPCSQKSGLIRHQKIHSGEKPYKCSDCGKAFLTKTMLIVHHRTHTGERPYGCDECEKAYFYMSCLVKHKRIHSREKRGDSVKVENPSTASHSLSPSEHVQGKSPVNMVTVAMVAGQCEFAHILHS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 49 | Phosphorylation | SNLVSVGYQAGKPDA CCHHHHHHHCCCCCH | 7.95 | - | |
| 58 | Phosphorylation | AGKPDALTKLEQGEP CCCCCHHHCHHCCCC | 34.99 | - | |
| 68 | Phosphorylation | EQGEPLWTLEDEIHS HCCCCCEEHHCCCCC | 28.14 | 29523821 | |
| 75 | Phosphorylation | TLEDEIHSPAHPEIE EHHCCCCCCCCCCHH | 29.46 | 29523821 | |
| 112 | Sumoylation | YEHGRTLKSYLGLTN CCCCCCHHHHHCCCC | 36.12 | 28112733 | |
| 311 | Phosphorylation | LLVVHQRTHTGEKPH EEEEECCCCCCCCCE | 19.74 | - | |
| 313 | Phosphorylation | VVHQRTHTGEKPHTC EEECCCCCCCCCEEC | 46.56 | - | |
| 339 | Phosphorylation | NLNIHQRTHTGEKPY CEEEECCCCCCCCCE | 19.74 | - | |
| 341 | Phosphorylation | NIHQRTHTGEKPYGC EEECCCCCCCCCEEE | 46.56 | - | |
| 344 | Acetylation | QRTHTGEKPYGCIDC CCCCCCCCCEEEECC | 44.90 | 7428889 | |
| 397 | Phosphorylation | IRHQKIHSGEKPYKC CCCCCCCCCCCCEEC | 52.71 | 29496963 | |
| 443 | Phosphorylation | EKAYFYMSCLVKHKR HHHHHHHHHHHHHHH | 7.91 | 24719451 | |
| 462 | Sumoylation | EKRGDSVKVENPSTA CCCCCCEEECCCCCC | 48.02 | - | |
| 467 | Phosphorylation | SVKVENPSTASHSLS CEEECCCCCCCCCCC | 48.46 | 21406692 | |
| 468 | Phosphorylation | VKVENPSTASHSLSP EEECCCCCCCCCCCH | 33.17 | 21406692 | |
| 470 | Phosphorylation | VENPSTASHSLSPSE ECCCCCCCCCCCHHH | 17.44 | 21406692 | |
| 472 | Phosphorylation | NPSTASHSLSPSEHV CCCCCCCCCCHHHCC | 28.22 | 21406692 | |
| 474 | Phosphorylation | STASHSLSPSEHVQG CCCCCCCCHHHCCCC | 29.42 | 21406692 | |
| 476 | Phosphorylation | ASHSLSPSEHVQGKS CCCCCCHHHCCCCCC | 36.64 | 21406692 | |
| 483 | Phosphorylation | SEHVQGKSPVNMVTV HHCCCCCCCCCHHHH | 40.69 | 28348404 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZN649_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZN649_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZN649_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SUV91_HUMAN | SUV39H1 | physical | 23455924 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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