GA45A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GA45A_HUMAN
• UniProt AC: P24522
• Protein Name: Growth arrest and DNA damage-inducible protein GADD45 alpha
• Gene Name: GADD45A
• Organism: Homo sapiens (Human).
• Sequence Length: 165
• Subcellular Localization: Nucleus .
• Protein Description: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase..
• Protein Sequence: MTLEEFSAGEQKTERMDKVGDALEEVLSKALSQRTITVGVYEAAKLLNVDPDNVVLCLLAADEDDDRDVALQIHFTLIQAFCCENDINILRVSNPGRLAELLLLETDAGPAASEGAEQPPDLHCVLVTNPHSSQWKDPALSQLICFCRESRYMDQWVPVINLPER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTLEEFSAG ------CCHHHCCCC	42.76	23186163
7	Phosphorylation	-MTLEEFSAGEQKTE -CCHHHCCCCHHHHH	38.35	23186163
12	Sumoylation	EFSAGEQKTERMDKV HCCCCHHHHHHHHHH	48.31	-
12	Sumoylation	EFSAGEQKTERMDKV HCCCCHHHHHHHHHH	48.31	-
12	Ubiquitination	EFSAGEQKTERMDKV HCCCCHHHHHHHHHH	48.31	21906983
18	Ubiquitination	QKTERMDKVGDALEE HHHHHHHHHHHHHHH	38.48	21906983
29	Ubiquitination	ALEEVLSKALSQRTI HHHHHHHHHHHCCCE	49.54	21890473
29	Ubiquitination	ALEEVLSKALSQRTI HHHHHHHHHHHCCCE	49.54	21890473
32	Phosphorylation	EVLSKALSQRTITVG HHHHHHHHCCCEEEE	23.60	-
41	Phosphorylation	RTITVGVYEAAKLLN CCEEEEHHHHHHHCC	8.23	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:23563151

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GA45A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GA45A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCTN2_HUMAN	DCTN2	physical	16189514
GA45A_HUMAN	GADD45A	physical	11498536
CDK1_HUMAN	CDK1	physical	10362260
PCNA_HUMAN	PCNA	physical	7478510
CDN1A_HUMAN	CDKN1A	physical	10912791
PCNA_HUMAN	PCNA	physical	10828065
PCNA_HUMAN	PCNA	physical	7784094
MK14_MOUSE	Mapk14	physical	12748288
CDK1_HUMAN	CDK1	physical	10973963
CDN1A_HUMAN	CDKN1A	physical	10973963
GA45G_HUMAN	GADD45G	physical	11498536
G45IP_HUMAN	GADD45GIP1	physical	12716909
ESR1_HUMAN	ESR1	physical	10872826
GA45B_HUMAN	GADD45B	physical	11498536
PCNA_HUMAN	PCNA	physical	7973727
PCNA_HUMAN	PCNA	physical	10973963
PPARA_MOUSE	Ppara	physical	10872826
PPARD_MOUSE	Ppard	physical	10872826
PPARG_MOUSE	Pparg	physical	10872826
RARA_HUMAN	RARA	physical	10872826
RXRA_HUMAN	RXRA	physical	10872826
CDK1_HUMAN	CDK1	physical	12124778
CCNB1_HUMAN	CCNB1	physical	12124778
MIDN_HUMAN	MIDN	physical	21900206
RS2_HUMAN	RPS2	physical	21900206
RXRA_HUMAN	RXRA	physical	21900206
IGS21_HUMAN	IGSF21	physical	21900206
P53_HUMAN	TP53	physical	21900206
CENPB_HUMAN	CENPB	physical	21900206
RAI1_HUMAN	RAI1	physical	21900206
SYNE4_HUMAN	SYNE4	physical	21900206
EF1G_HUMAN	EEF1G	physical	21900206
EF1A1_HUMAN	EEF1A1	physical	21900206
GBB2_HUMAN	GNB2	physical	21900206
FBN3_HUMAN	FBN3	physical	21900206
DJC13_HUMAN	DNAJC13	physical	21900206
ERG28_HUMAN	C14orf1	physical	21900206
ADAP1_HUMAN	ADAP1	physical	21900206
UBR1_HUMAN	UBR1	physical	21900206
LMO4_HUMAN	LMO4	physical	21900206
GBP2_HUMAN	GBP2	physical	21900206
BAG6_HUMAN	BAG6	physical	21900206
UB2D1_HUMAN	UBE2D1	physical	21900206
F264_HUMAN	PFKFB4	physical	21900206
G3P_HUMAN	GAPDH	physical	21900206
MICA1_HUMAN	MICAL1	physical	21900206
EM55_HUMAN	MPP1	physical	21900206
JHD2C_HUMAN	JMJD1C	physical	21900206
VIME_HUMAN	VIM	physical	21900206
SPTN4_HUMAN	SPTBN4	physical	21900206
CHD3_HUMAN	CHD3	physical	21900206
ZHX1_HUMAN	ZHX1	physical	21900206
SYQ_HUMAN	QARS	physical	21900206
FA83D_HUMAN	FAM83D	physical	21900206
ZN135_HUMAN	ZNF135	physical	21900206
FUBP2_HUMAN	KHSRP	physical	21900206
TLE1_HUMAN	TLE1	physical	21900206
SUH_HUMAN	RBPJ	physical	21900206
NRBP_HUMAN	NRBP1	physical	21900206
MASP1_HUMAN	MASP1	physical	21900206
TETN_HUMAN	CLEC3B	physical	21900206
PTN_HUMAN	PTN	physical	21900206
DNMT1_HUMAN	DNMT1	physical	22135303
MK01_HUMAN	MAPK1	physical	20932473
RS7_HUMAN	RPS7	physical	23563151
MDM2_HUMAN	MDM2	physical	23563151
NUCB2_HUMAN	NUCB2	physical	21988832
SHLB1_HUMAN	SH3GLB1	physical	21988832
PTPRK_HUMAN	PTPRK	physical	21988832
PRS6A_HUMAN	PSMC3	physical	21988832
PCNA_HUMAN	PCNA	physical	23485469
APEX1_HUMAN	APEX1	physical	23485469
ING4_HUMAN	ING4	physical	23388825
MTOR_HUMAN	MTOR	physical	23329839
STAT3_HUMAN	STAT3	physical	23329839
PCNA_HUMAN	PCNA	physical	20460379
AURKA_HUMAN	AURKA	physical	20460379
CDK1_HUMAN	CDK1	physical	18942077

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.