HPPD_HUMAN - dbPTM
HPPD_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HPPD_HUMAN
UniProt AC P32754
Protein Name 4-hydroxyphenylpyruvate dioxygenase
Gene Name HPD
Organism Homo sapiens (Human).
Sequence Length 393
Subcellular Localization
Protein Description Key enzyme in the degradation of tyrosine..
Protein Sequence MTTYSDKGAKPERGRFLHFHSVTFWVGNAKQAASFYCSKMGFEPLAYRGLETGSREVVSHVIKQGKIVFVLSSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDYIVQKARERGAKIMREPWVEQDKFGKVKFAVLQTYGDTTHTLVEKMNYIGQFLPGYEAPAFMDPLLPKLPKCSLEMIDHIVGNQPDQEMVSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGKKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGLEFLSVPSTYYKQLREKLKTAKIKVKENIDALEELKILVDYDEKGYLLQIFTKPVQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQNLRGNLTNMETNGVVPGM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MTTYSDKGA
------CCCCCCCCC		34.1522814378
4Phosphorylation----MTTYSDKGAKP
----CCCCCCCCCCC		13.00-
24UbiquitinationLHFHSVTFWVGNAKQ
EEEEEEEEEECCHHH		4.6921963094
27UbiquitinationHSVTFWVGNAKQAAS
EEEEEEECCHHHHHH		20.9722817900
39AcetylationAASFYCSKMGFEPLA
HHHHHHHHCCCCCCH		39.2126051181
39UbiquitinationAASFYCSKMGFEPLA
HHHHHHHHCCCCCCH		39.2121963094
41UbiquitinationSFYCSKMGFEPLAYR
HHHHHHCCCCCCHHC		27.7421963094
55UbiquitinationRGLETGSREVVSHVI
CCCCCCCHHHHHHHH		41.9121963094
63AcetylationEVVSHVIKQGKIVFV
HHHHHHHHCCCEEEE		52.4926051181
63UbiquitinationEVVSHVIKQGKIVFV
HHHHHHHHCCCEEEE		52.4921963094
66UbiquitinationSHVIKQGKIVFVLSS
HHHHHCCCEEEEEEC		32.9522817900
70UbiquitinationKQGKIVFVLSSALNP
HCCCEEEEEECCCCC		3.3421963094
80UbiquitinationSALNPWNKEMGDHLV
CCCCCCHHHHHHHHH		45.2521963094
88UbiquitinationEMGDHLVKHGDGVKD
HHHHHHHHCCCCCCE		48.5121963094
91UbiquitinationDHLVKHGDGVKDIAF
HHHHHCCCCCCEEEE		59.4322817900
93UbiquitinationLVKHGDGVKDIAFEV
HHHCCCCCCEEEEEE		6.3122817900
94UbiquitinationVKHGDGVKDIAFEVE
HHCCCCCCEEEEEEE		49.2821963094
105PhosphorylationFEVEDCDYIVQKARE
EEEECCHHHHHHHHH		14.88-
109UbiquitinationDCDYIVQKARERGAK
CCHHHHHHHHHHCCH		38.2221963094
127UbiquitinationEPWVEQDKFGKVKFA
CCCCCCCCCCCEEEE		56.5621963094
127AcetylationEPWVEQDKFGKVKFA
CCCCCCCCCCCEEEE		56.5626051181
130AcetylationVEQDKFGKVKFAVLQ
CCCCCCCCEEEEEEE		45.4426051181
130UbiquitinationVEQDKFGKVKFAVLQ
CCCCCCCCEEEEEEE		45.4422817900
132SuccinylationQDKFGKVKFAVLQTY
CCCCCCEEEEEEECC		30.96-
132UbiquitinationQDKFGKVKFAVLQTY
CCCCCCEEEEEEECC		30.9622817900
132SuccinylationQDKFGKVKFAVLQTY
CCCCCCEEEEEEECC		30.96-
132AcetylationQDKFGKVKFAVLQTY
CCCCCCEEEEEEECC		30.9626051181
133UbiquitinationDKFGKVKFAVLQTYG
CCCCCEEEEEEECCC		6.7822817900
136UbiquitinationGKVKFAVLQTYGDTT
CCEEEEEEECCCCCH		2.5621963094
163UbiquitinationFLPGYEAPAFMDPLL
CCCCCCCCCCCCCHH		17.6821963094
172UbiquitinationFMDPLLPKLPKCSLE
CCCCHHCCCCCCCHH		76.9022817900
175UbiquitinationPLLPKLPKCSLEMID
CHHCCCCCCCHHHHH		47.0621963094
198UbiquitinationQEMVSASEWYLKNLQ
HHHHCHHHHHHHHCC		39.6021963094
202UbiquitinationSASEWYLKNLQFHRF
CHHHHHHHHCCEEEE		39.6621963094
208UbiquitinationLKNLQFHRFWSVDDT
HHHCCEEEEEECCCC		35.7021963094
209UbiquitinationKNLQFHRFWSVDDTQ
HHCCEEEEEECCCCC		4.2422817900
210UbiquitinationNLQFHRFWSVDDTQV
HCCEEEEEECCCCCC		9.4521963094
211PhosphorylationLQFHRFWSVDDTQVH
CCEEEEEECCCCCCC		16.9828857561
215PhosphorylationRFWSVDDTQVHTEYS
EEEECCCCCCCCCHH		28.2022210691
219PhosphorylationVDDTQVHTEYSSLRS
CCCCCCCCCHHHCCE		37.4525072903
221PhosphorylationDTQVHTEYSSLRSIV
CCCCCCCHHHCCEEE		12.5221253578
222PhosphorylationTQVHTEYSSLRSIVV
CCCCCCHHHCCEEEE		19.3620166139
223PhosphorylationQVHTEYSSLRSIVVA
CCCCCHHHCCEEEEE		27.2220166139
226PhosphorylationTEYSSLRSIVVANYE
CCHHHCCEEEEECHH		25.6520068231
231UbiquitinationLRSIVVANYEESIKM
CCEEEEECHHHHCCC		32.8921963094
232PhosphorylationRSIVVANYEESIKMP
CEEEEECHHHHCCCC		16.0120068231
235PhosphorylationVVANYEESIKMPINE
EEECHHHHCCCCCCC		18.6420068231
237UbiquitinationANYEESIKMPINEPA
ECHHHHCCCCCCCCC		48.1521963094
247UbiquitinationINEPAPGKKKSQIQE
CCCCCCCCCHHHHHH		56.8421963094
247AcetylationINEPAPGKKKSQIQE
CCCCCCCCCHHHHHH		56.8426051181
248UbiquitinationNEPAPGKKKSQIQEY
CCCCCCCCHHHHHHH		64.6722817900
249UbiquitinationEPAPGKKKSQIQEYV
CCCCCCCHHHHHHHH		51.5921963094
250PhosphorylationPAPGKKKSQIQEYVD
CCCCCCHHHHHHHHC		41.2021082442
258UbiquitinationQIQEYVDYNGGAGVQ
HHHHHHCCCCCCCCE		12.9821890473
258UbiquitinationQIQEYVDYNGGAGVQ
HHHHHHCCCCCCCCE		12.9821890473
263UbiquitinationVDYNGGAGVQHIALK
HCCCCCCCCEEEEEC		23.9222817900
268UbiquitinationGAGVQHIALKTEDII
CCCCEEEEECHHHHH		10.8122817900
270UbiquitinationGVQHIALKTEDIITA
CCEEEEECHHHHHHH		40.6321963094
272UbiquitinationQHIALKTEDIITAIR
EEEEECHHHHHHHHH		45.7021963094
290PhosphorylationERGLEFLSVPSTYYK
HCCCCHHCCCHHHHH		36.9820068231
293PhosphorylationLEFLSVPSTYYKQLR
CCHHCCCHHHHHHHH		27.2124275569
295PhosphorylationFLSVPSTYYKQLREK
HHCCCHHHHHHHHHH		17.01-
296PhosphorylationLSVPSTYYKQLREKL
HCCCHHHHHHHHHHH		7.73-
297UbiquitinationSVPSTYYKQLREKLK
CCCHHHHHHHHHHHH		32.2321963094
302UbiquitinationYYKQLREKLKTAKIK
HHHHHHHHHHHCCCE		49.1822817900
307UbiquitinationREKLKTAKIKVKENI
HHHHHHCCCEEHHCC		48.5722817900
309UbiquitinationKLKTAKIKVKENIDA
HHHHCCCEEHHCCHH		46.6922817900
311AcetylationKTAKIKVKENIDALE
HHCCCEEHHCCHHHH		39.7926051181
311UbiquitinationKTAKIKVKENIDALE
HHCCCEEHHCCHHHH		39.7921963094
330UbiquitinationLVDYDEKGYLLQIFT
EEECCCCCEEEEEEE		19.1021963094
366PhosphorylationFGAGNFNSLFKAFEE
CCCCCHHHHHHHHHH		30.9224719451
369UbiquitinationGNFNSLFKAFEEEQN
CCHHHHHHHHHHHHC		58.4121963094
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HPPD_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HPPD_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HPPD_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NEMO_HUMANIKBKGphysical
21988832
RIDA_HUMANHRSP12physical
21988832
ASPC1_HUMANASPSCR1physical
26186194
ASPC1_HUMANASPSCR1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
276710Tyrosinemia 3 (TYRSN3)
140350Hawkinsinuria (HAWK)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00348Nitisinone
Regulatory Network of HPPD_HUMAN

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Related Literatures of Post-Translational Modification

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