GCKR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCKR_HUMAN
• UniProt AC: Q14397
• Protein Name: Glucokinase regulatory protein
• Gene Name: GCKR
• Organism: Homo sapiens (Human).
• Sequence Length: 625
• Subcellular Localization: Cytoplasm . Nucleus . Under low glucose concentrations, GKRP associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.
• Protein Description: Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity..
• Protein Sequence: MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEIFQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
164	Acetylation	LHGIEELKKVAAGKK HHHHHHHHHHHCCCC	48.78	15618511
280	Phosphorylation	LLLAAHKTVDQGIAA HHHHHHCCHHHHHHH	21.32	-
306	Phosphorylation	FERAHQVTYSQSPKI HHHHHCCCCCCCHHH	15.75	25690035
315	Phosphorylation	SQSPKIATLMKSVST CCCHHHHHHHHHHHH	30.75	-
321	Phosphorylation	ATLMKSVSTSLEKKG HHHHHHHHHHHHHCC	21.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCKR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCKR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCKR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HXK4_HUMAN	GCK	physical	10601273
HXK4_HUMAN	GCK	physical	26620281
SIR2_HUMAN	SIRT2	physical	26620281
EP300_HUMAN	EP300	physical	26620281

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.