HXK4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXK4_HUMAN
• UniProt AC: P35557
• Protein Name: Glucokinase
• Gene Name: GCK
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Subcellular Localization: Cytoplasm . Nucleus . Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus.
• Protein Description: Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage..
• Protein Sequence: MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
161	Sumoylation	VRHEDIDKGILLNWT ECHHHCCCCEEEEEC	48.46	-
161	Sumoylation	VRHEDIDKGILLNWT ECHHHCCCCEEEEEC	48.46	-
169	Sumoylation	GILLNWTKGFKASGA CEEEEECCCCCCCCC	54.70	-
169	Sumoylation	GILLNWTKGFKASGA CEEEEECCCCCCCCC	54.70	-
263	Phosphorylation	EWGAFGDSGELDEFL CCCCCCCCCCHHHHH	34.25	22210691
280	Phosphorylation	YDRLVDESSANPGQQ HHHHHCCCCCCCCHH	30.22	22210691
289	Phosphorylation	ANPGQQLYEKLIGGK CCCCHHHHHHHHCCC	13.48	22210691
346	Sumoylation	ESDTGDRKQIYNILS ECCCCCHHHHHHHHH	45.87	-
346	Sumoylation	ESDTGDRKQIYNILS ECCCCCHHHHHHHHH	45.87	-
349	Phosphorylation	TGDRKQIYNILSTLG CCCHHHHHHHHHHCC	8.15	24043423
353	Phosphorylation	KQIYNILSTLGLRPS HHHHHHHHHCCCCCC	20.14	24043423
354	Phosphorylation	QIYNILSTLGLRPST HHHHHHHHCCCCCCC	22.77	24043423
360	Phosphorylation	STLGLRPSTTDCDIV HHCCCCCCCCCCHHH	37.19	24043423
361	Phosphorylation	TLGLRPSTTDCDIVR HCCCCCCCCCCHHHH	29.36	24043423
362	Phosphorylation	LGLRPSTTDCDIVRR CCCCCCCCCCHHHHH	38.68	24043423
371	S-nitrosocysteine	CDIVRRACESVSTRA CHHHHHHHHHCHHHH	3.67	-
371	S-nitrosylation	CDIVRRACESVSTRA CHHHHHHHHHCHHHH	3.67	22178444
373	Phosphorylation	IVRRACESVSTRAAH HHHHHHHHCHHHHHH	22.66	-
375	Phosphorylation	RRACESVSTRAAHMC HHHHHHCHHHHHHHH	22.81	-
376	Phosphorylation	RACESVSTRAAHMCS HHHHHCHHHHHHHHH	23.36	-
383	Phosphorylation	TRAAHMCSAGLAGVI HHHHHHHHHHHHHHH	20.14	-
411	Phosphorylation	ITVGVDGSVYKLHPS EEECCCCCEEECCHH	20.15	21420961
413	Phosphorylation	VGVDGSVYKLHPSFK ECCCCCEEECCHHHH	14.99	-
414	Sumoylation	GVDGSVYKLHPSFKE CCCCCEEECCHHHHH	37.86	-
414	Sumoylation	GVDGSVYKLHPSFKE CCCCCEEECCHHHHH	37.86	-
458	Sumoylation	LVSAVACKKACMLGQ HHHHHHHHHHHHCCC	33.40	-
458	Sumoylation	LVSAVACKKACMLGQ HHHHHHHHHHHHCCC	33.40	-
459	Sumoylation	VSAVACKKACMLGQ- HHHHHHHHHHHCCC-	46.86	-
459	Sumoylation	VSAVACKKACMLGQ- HHHHHHHHHHHCCC-	46.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXK4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXK4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXK4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
F262_HUMAN	PFKFB2	physical	11522786
GDE_HUMAN	AGL	physical	26344197
GMIP_HUMAN	GMIP	physical	26344197
P4R3B_HUMAN	SMEK2	physical	26344197
UGPA_HUMAN	UGP2	physical	26344197
GCKR_HUMAN	GCKR	physical	26620281

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 125851: Maturity-onset diabetes of the young 2 (MODY2)
• 602485: Familial hyperinsulinemic hypoglycemia 3 (HHF3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.