CF089_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CF089_HUMAN
• UniProt AC: Q6UWU4
• Protein Name: Bombesin receptor-activated protein C6orf89
• Gene Name: C6orf89
• Organism: Homo sapiens (Human).
• Sequence Length: 347
• Subcellular Localization: Isoform 1: Golgi apparatus membrane ; Single-pass type II membrane protein . Midbody .; Isoform 2: Golgi apparatus membrane ; Single-pass type II membrane protein . Midbody .; Isoform 3: Cytoplasm . Nucleus, nucleolus . Retained in nucleolar organise
• Protein Description: Exhibits histone deacetylase (HDAC) enhancer properties. [PubMed: 23460338 May play a role in cell cycle progression and wound repair of bronchial epithelial cells]
• Protein Sequence: MDLAANEISIYDKLSETVDLVRQTGHQCGMSEKAIEKFIRQLLEKNEPQRPPPQYPLLIVVYKVLATLGLILLTAYFVIQPFSPLAPEPVLSGAHTWRSLIHHIRLMSLPIAKKYMSENKGVPLHGGDEDRPFPDFDPWWTNDCEQNESEPIPANCTGCAQKHLKVMLLEDAPRKFERLHPLVIKTGKPLLEEEIQHFLCQYPEATEGFSEGFFAKWWRCFPERWFPFPYPWRRPLNRSQMLRELFPVFTHLPFPKDASLNKCSFLHPEPVVGSKMHKMPDLFIIGSGEAMLQLIPPFQCRRHCQSVAMPIEPGDIGYVDTTHWKVYVIARGVQPLVICDGTAFSEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	NEISIYDKLSETVDL HCCCHHHHHHHHHHH	36.62	-
33	Ubiquitination	HQCGMSEKAIEKFIR CCCCCCHHHHHHHHH	47.56	-
37	Ubiquitination	MSEKAIEKFIRQLLE CCHHHHHHHHHHHHH	39.72	-
37 (in isoform 1)	Ubiquitination	-	39.72	21890473
37	Ubiquitination	MSEKAIEKFIRQLLE CCHHHHHHHHHHHHH	39.72	21890473
40 (in isoform 2)	Ubiquitination	-	24.99	-
44 (in isoform 2)	Ubiquitination	-	63.53	21890473
59	Ubiquitination	PPQYPLLIVVYKVLA CCCCCHHHHHHHHHH	2.31	21906983
150	Ubiquitination	DCEQNESEPIPANCT CCCCCCCCCCCCCCC	40.86	-
156	Ubiquitination	SEPIPANCTGCAQKH CCCCCCCCCHHHHHH	3.62	-
165	Ubiquitination	GCAQKHLKVMLLEDA HHHHHHHHEEECCCC	25.89	2190698
165 (in isoform 1)	Ubiquitination	-	25.89	21890473
169	Ubiquitination	KHLKVMLLEDAPRKF HHHHEEECCCCCCHH	2.78	-
172 (in isoform 2)	Ubiquitination	-	9.09	21890473
185	Ubiquitination	RLHPLVIKTGKPLLE HHHHEEECCCCCCHH	43.69	-
188	Ubiquitination	PLVIKTGKPLLEEEI HEEECCCCCCHHHHH	37.41	-
256	Ubiquitination	FTHLPFPKDASLNKC HHCCCCCCCCCCCCC	67.32	-
262	Ubiquitination	PKDASLNKCSFLHPE CCCCCCCCCCCCCCC	36.23	-
263 (in isoform 2)	Ubiquitination	-	3.19	-
269 (in isoform 2)	Ubiquitination	-	39.72	-
275	Ubiquitination	PEPVVGSKMHKMPDL CCCCCCCCCCCCCCE	38.81	-
282 (in isoform 2)	Ubiquitination	-	2.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CF089_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CF089_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CF089_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTRD1_HUMAN	PTRHD1	physical	26186194
PTRD1_HUMAN	PTRHD1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.