| UniProt ID | AGRG6_HUMAN | |
|---|---|---|
| UniProt AC | Q86SQ4 | |
| Protein Name | Adhesion G-protein coupled receptor G6 | |
| Gene Name | ADGRG6 {ECO:0000312|HGNC:HGNC:13841} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1221 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Detected on the cell surface of activated but not resting umbilical vein. |
|
| Protein Description | G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins. [PubMed: 24227709 Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons] | |
| Protein Sequence | MMFRSDRMWSCHWKWKPSPLLFLFALYIMCVPHSVWGCANCRVVLSNPSGTFTSPCYPNDYPNSQACMWTLRAPTGYIIQITFNDFDIEEAPNCIYDSLSLDNGESQTKFCGATAKGLSFNSSANEMHVSFSSDFSIQKKGFNASYIRVAVSLRNQKVILPQTSDAYQVSVAKSISIPELSAFTLCFEATKVGHEDSDWTAFSYSNASFTQLLSFGKAKSGYFLSISDSKCLLNNALPVKEKEDIFAESFEQLCLVWNNSLGSIGVNFKRNYETVPCDSTISKVIPGNGKLLLGSNQNEIVSLKGDIYNFRLWNFTMNAKILSNLSCNVKGNVVDWQNDFWNIPNLALKAESNLSCGSYLIPLPAAELASCADLGTLCQATVNSPSTTPPTVTTNMPVTNRIDKQRNDGIIYRISVVIQNILRHPEVKVQSKVAEWLNSTFQNWNYTVYVVNISFHLSAGEDKIKVKRSLEDEPRLVLWALLVYNATNNTNLEGKIIQQKLLKNNESLDEGLRLHTVNVRQLGHCLAMEEPKGYYWPSIQPSEYVLPCPDKPGFSASRICFYNATNPLVTYWGPVDISNCLKEANEVANQILNLTADGQNLTSANITNIVEQVKRIVNKEENIDITLGSTLMNIFSNILSSSDSDLLESSSEALKTIDELAFKIDLNSTSHVNITTRNLALSVSSLLPGTNAISNFSIGLPSNNESYFQMDFESGQVDPLASVILPPNLLENLSPEDSVLVRRAQFTFFNKTGLFQDVGPQRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEVHHPICAFWDLNKNKSFGGWNTSGCVAHRDSDASETVCLCNHFTHFGVLMDLPRSASQLDARNTKVLTFISYIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDGWITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYILKFCIIGWGLPALVVSVVLASRNNNEVYGKESYGKEKGDEFCWIQDPVIFYVTCAGYFGVMFFLNIAMFIVVMVQICGRNGKRSNRTLREEVLRNLRSVVSLTFLLGMTWGFAFFAWGPLNIPFMYLFSIFNSLQGLFIFIFHCAMKENVQKQWRQHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLSSSSIGSNSTYLTSKSKSSSTTYFKRNSHTDNVSYEHSFNKSGSLRQCFHGQVLVKTGPC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MMFRSDRMWSCH ---CCCCCCCCCCCC | 30631047 | ||
| 121 | N-linked_Glycosylation | TAKGLSFNSSANEMH CCCCCCCCCCCCEEE | UniProtKB CARBOHYD | ||
| 143 | N-linked_Glycosylation | SIQKKGFNASYIRVA CCCCCCCCHHHEEEE | 16335952 | ||
| 206 | N-linked_Glycosylation | WTAFSYSNASFTQLL CEEEEECCCCHHHHH | UniProtKB CARBOHYD | ||
| 208 | Phosphorylation | AFSYSNASFTQLLSF EEEECCCCHHHHHHC | 26853621 | ||
| 258 | N-linked_Glycosylation | EQLCLVWNNSLGSIG HHHHHHCCCCCCCEE | UniProtKB CARBOHYD | ||
| 314 | N-linked_Glycosylation | IYNFRLWNFTMNAKI EEEEEEEEEECCEEH | UniProtKB CARBOHYD | ||
| 324 | N-linked_Glycosylation | MNAKILSNLSCNVKG CCEEHHHCCCCCCCC | 15084671 | ||
| 353 | N-linked_Glycosylation | LALKAESNLSCGSYL HHHHCCCCCCCCCEE | UniProtKB CARBOHYD | ||
| 428 | Acetylation | ILRHPEVKVQSKVAE HHHCCCCHHHHHHHH | 7927347 | ||
| 438 | N-linked_Glycosylation | SKVAEWLNSTFQNWN HHHHHHHHHHHCCCC | 16335952 | ||
| 439 | Phosphorylation | KVAEWLNSTFQNWNY HHHHHHHHHHCCCCE | 27251275 | ||
| 440 | Phosphorylation | VAEWLNSTFQNWNYT HHHHHHHHHCCCCEE | 27251275 | ||
| 445 | N-linked_Glycosylation | NSTFQNWNYTVYVVN HHHHCCCCEEEEEEE | 16335952 | ||
| 446 | Phosphorylation | STFQNWNYTVYVVNI HHHCCCCEEEEEEEE | 27251275 | ||
| 447 | Phosphorylation | TFQNWNYTVYVVNIS HHCCCCEEEEEEEEE | 27251275 | ||
| 452 | N-linked_Glycosylation | NYTVYVVNISFHLSA CEEEEEEEEEEEECC | UniProtKB CARBOHYD | ||
| 485 | N-linked_Glycosylation | LWALLVYNATNNTNL HEEHHHHHCCCCCCC | UniProtKB CARBOHYD | ||
| 488 | N-linked_Glycosylation | LLVYNATNNTNLEGK HHHHHCCCCCCCCHH | UniProtKB CARBOHYD | ||
| 505 | N-linked_Glycosylation | QQKLLKNNESLDEGL HHHHHHCCCCCCCCC | UniProtKB CARBOHYD | ||
| 563 | N-linked_Glycosylation | ASRICFYNATNPLVT HHHEEEEECCCCEEE | UniProtKB CARBOHYD | ||
| 593 | N-linked_Glycosylation | EVANQILNLTADGQN HHHHHHHCCCCCCCC | UniProtKB CARBOHYD | ||
| 600 | N-linked_Glycosylation | NLTADGQNLTSANIT CCCCCCCCCCCCCHH | UniProtKB CARBOHYD | ||
| 605 | N-linked_Glycosylation | GQNLTSANITNIVEQ CCCCCCCCHHHHHHH | UniProtKB CARBOHYD | ||
| 667 | N-linked_Glycosylation | LAFKIDLNSTSHVNI HCHHCCCCCCCCCEE | UniProtKB CARBOHYD | ||
| 673 | N-linked_Glycosylation | LNSTSHVNITTRNLA CCCCCCCEEEHHCEE | UniProtKB CARBOHYD | ||
| 695 | N-linked_Glycosylation | PGTNAISNFSIGLPS CCCCCCCCEEEECCC | UniProtKB CARBOHYD | ||
| 704 | N-linked_Glycosylation | SIGLPSNNESYFQMD EEECCCCCCCEEEEE | UniProtKB CARBOHYD | ||
| 750 | N-linked_Glycosylation | RAQFTFFNKTGLFQD EEEEEEECCCCCCCC | UniProtKB CARBOHYD | ||
| 776 | N-linked_Glycosylation | VMACSIGNITIQNLK HHHHHHCCEEECCCC | UniProtKB CARBOHYD | ||
| 811 | N-linked_Glycosylation | AFWDLNKNKSFGGWN EEEECCCCCCCCCCC | UniProtKB CARBOHYD | ||
| 818 | N-linked_Glycosylation | NKSFGGWNTSGCVAH CCCCCCCCCCCCEEE | UniProtKB CARBOHYD | ||
| 882 | Phosphorylation | SAIFSAATLLTYVAF HHHHHHHHHHHHHHH | 25332170 | ||
| 886 | Phosphorylation | SAATLLTYVAFEKLR HHHHHHHHHHHHHHH | 25332170 | ||
| 965 | Phosphorylation | ALVKVFNTYIRRYIL HHHHHHHHHHHHHHH | - | ||
| 970 | Phosphorylation | FNTYIRRYILKFCII HHHHHHHHHHHHHHH | 24425749 | ||
| 987 | Phosphorylation | GLPALVVSVVLASRN CHHHHHHHHHHHCCC | 24425749 | ||
| 1116 | Ubiquitination | FIFIFHCAMKENVQK HHHHHHHHHHHHHHH | 33845483 | ||
| 1123 | Ubiquitination | AMKENVQKQWRQHLC HHHHHHHHHHHHHCC | 33845483 | ||
| 1131 | Ubiquitination | QWRQHLCCGRFRLAD HHHHHCCCCCEEECC | 32015554 | ||
| 1137 | Phosphorylation | CCGRFRLADNSDWSK CCCCEEECCCCCCHH | 32645325 | ||
| 1140 | Phosphorylation | RFRLADNSDWSKTAT CEEECCCCCCHHHHH | 33259812 | ||
| 1144 | Ubiquitination | ADNSDWSKTATNIIK CCCCCCHHHHHHHHH | 33845483 | ||
| 1147 | Phosphorylation | SDWSKTATNIIKKSS CCCHHHHHHHHHHCC | 23911959 | ||
| 1148 | Ubiquitination | DWSKTATNIIKKSSD CCHHHHHHHHHHCCC | 21963094 | ||
| 1149 | Ubiquitination | WSKTATNIIKKSSDN CHHHHHHHHHHCCCC | 21963094 | ||
| 1150 | Ubiquitination | SKTATNIIKKSSDNL HHHHHHHHHHCCCCC | 33845483 | ||
| 1151 | Ubiquitination | KTATNIIKKSSDNLG HHHHHHHHHCCCCCC | 33845483 | ||
| 1153 | Phosphorylation | ATNIIKKSSDNLGKS HHHHHHHCCCCCCCC | 30576142 | ||
| 1154 | Phosphorylation | TNIIKKSSDNLGKSL HHHHHHCCCCCCCCC | - | ||
| 1158 | Ubiquitination | KKSSDNLGKSLSSSS HHCCCCCCCCCCCCC | 29967540 | ||
| 1159 | Ubiquitination | KSSDNLGKSLSSSSI HCCCCCCCCCCCCCC | 32015554 | ||
| 1160 | Phosphorylation | SSDNLGKSLSSSSIG CCCCCCCCCCCCCCC | 21945579 | ||
| 1161 (in isoform 4) | Phosphorylation | - | - | ||
| 1162 | Phosphorylation | DNLGKSLSSSSIGSN CCCCCCCCCCCCCCC | 21945579 | ||
| 1163 | Phosphorylation | NLGKSLSSSSIGSNS CCCCCCCCCCCCCCC | 21945579 | ||
| 1164 | Phosphorylation | LGKSLSSSSIGSNST CCCCCCCCCCCCCCC | 21945579 | ||
| 1165 | Phosphorylation | GKSLSSSSIGSNSTY CCCCCCCCCCCCCCE | 21945579 | ||
| 1168 | Phosphorylation | LSSSSIGSNSTYLTS CCCCCCCCCCCEEEE | 21945579 | ||
| 1170 | Phosphorylation | SSSIGSNSTYLTSKS CCCCCCCCCEEEECC | 21945579 | ||
| 1171 | Phosphorylation | SSIGSNSTYLTSKSK CCCCCCCCEEEECCC | 21945579 | ||
| 1172 | Phosphorylation | SIGSNSTYLTSKSKS CCCCCCCEEEECCCC | 21945579 | ||
| 1174 | Phosphorylation | GSNSTYLTSKSKSSS CCCCCEEEECCCCCC | 21945579 | ||
| 1174 | Ubiquitination | GSNSTYLTSKSKSSS CCCCCEEEECCCCCC | 33845483 | ||
| 1175 | Ubiquitination | SNSTYLTSKSKSSST CCCCEEEECCCCCCC | 21963094 | ||
| 1175 | Phosphorylation | SNSTYLTSKSKSSST CCCCEEEECCCCCCC | 21945579 | ||
| 1176 | Ubiquitination | NSTYLTSKSKSSSTT CCCEEEECCCCCCCC | 21963094 | ||
| 1177 | Ubiquitination | STYLTSKSKSSSTTY CCEEEECCCCCCCCE | 21963094 | ||
| 1177 | Phosphorylation | STYLTSKSKSSSTTY CCEEEECCCCCCCCE | 30576142 | ||
| 1178 | Ubiquitination | TYLTSKSKSSSTTYF CEEEECCCCCCCCEE | 33845483 | ||
| 1178 | Methylation | TYLTSKSKSSSTTYF CEEEECCCCCCCCEE | - | ||
| 1179 | Ubiquitination | YLTSKSKSSSTTYFK EEEECCCCCCCCEEE | 27667366 | ||
| 1179 | Phosphorylation | YLTSKSKSSSTTYFK EEEECCCCCCCCEEE | 29083192 | ||
| 1180 | Phosphorylation | LTSKSKSSSTTYFKR EEECCCCCCCCEEEC | 27251275 | ||
| 1181 | Phosphorylation | TSKSKSSSTTYFKRN EECCCCCCCCEEECC | 26657352 | ||
| 1182 | Phosphorylation | SKSKSSSTTYFKRNS ECCCCCCCCEEECCC | 28152594 | ||
| 1183 (in isoform 4) | Phosphorylation | - | 25850435 | ||
| 1183 | Phosphorylation | KSKSSSTTYFKRNSH CCCCCCCCEEECCCC | 28152594 | ||
| 1184 | Phosphorylation | SKSSSTTYFKRNSHT CCCCCCCEEECCCCC | 28152594 | ||
| 1184 (in isoform 4) | Phosphorylation | - | 25850435 | ||
| 1186 | Ubiquitination | SSSTTYFKRNSHTDN CCCCCEEECCCCCCC | 29967540 | ||
| 1186 | Methylation | SSSTTYFKRNSHTDN CCCCCEEECCCCCCC | - | ||
| 1189 | Phosphorylation | TTYFKRNSHTDNVSY CCEEECCCCCCCCCE | 25849741 | ||
| 1189 | Ubiquitination | TTYFKRNSHTDNVSY CCEEECCCCCCCCCE | 33845483 | ||
| 1191 | Phosphorylation | YFKRNSHTDNVSYEH EEECCCCCCCCCEEE | 25849741 | ||
| 1195 | Phosphorylation | NSHTDNVSYEHSFNK CCCCCCCCEEEECCC | 25849741 | ||
| 1196 | Phosphorylation | SHTDNVSYEHSFNKS CCCCCCCEEEECCCC | 23927012 | ||
| 1199 | Phosphorylation | DNVSYEHSFNKSGSL CCCCEEEECCCCCCC | 23403867 | ||
| 1202 | Ubiquitination | SYEHSFNKSGSLRQC CEEEECCCCCCCEEE | 33845483 | ||
| 1203 | Phosphorylation | YEHSFNKSGSLRQCF EEEECCCCCCCEEEE | 22617229 | ||
| 1205 | Phosphorylation | HSFNKSGSLRQCFHG EECCCCCCCEEEECC | 25849741 | ||
| 1211 (in isoform 3) | Phosphorylation | - | 25850435 | ||
| 1212 (in isoform 3) | Phosphorylation | - | 25850435 | ||
| 1217 | Ubiquitination | FHGQVLVKTGPC--- ECCEEEEEECCC--- | 33845483 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of AGRG6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AGRG6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AGRG6_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of AGRG6_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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