HSP13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSP13_HUMAN
• UniProt AC: P48723
• Protein Name: Heat shock 70 kDa protein 13
• Gene Name: HSPA13
• Organism: Homo sapiens (Human).
• Sequence Length: 471
• Subcellular Localization: Microsome. Endoplasmic reticulum.
• Protein Description: Has peptide-independent ATPase activity..
• Protein Sequence: MAREMTILGSAVLTLLLAGYLAQQYLPLPTPKVIGIDLGTTYCSVGVFFPGTGKVKVIPDENGHISIPSMVSFTDNDVYVGYESVELADSNPQNTIYDAKRFIGKIFTAEELEAEIGRYPFKVLNKNGMVEFSVTSNETITVSPEYVGSRLLLKLKEMAEAYLGMPVANAVISVPAEFDLKQRNSTIEAANLAGLKILRVINEPTAAAMAYGLHKADVFHVLVIDLGGGTLDVSLLNKQGGMFLTRAMSGNNKLGGQDFNQRLLQYLYKQIYQTYGFVPSRKEEIHRLRQAVEMVKLNLTLHQSAQLSVLLTVEEQDRKEPHSSDTELPKDKLSSADDHRVNSGFGRGLSDKKSGESQVLFETEISRKLFDTLNEDLFQKILVPIQQVLKEGHLEKTEIDEVVLVGGSTRIPRIRQVIQEFFGKDPNTSVDPDLAVVTGVAIQAGIDGGSWPLQVSALEIPNKHLQKTNFN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAREMTILGSAVL --CCHHHHHHHHHHH	14.32	24043423
10	Phosphorylation	REMTILGSAVLTLLL HHHHHHHHHHHHHHH	16.26	24043423
14	Phosphorylation	ILGSAVLTLLLAGYL HHHHHHHHHHHHHHH	14.57	24043423
20	Phosphorylation	LTLLLAGYLAQQYLP HHHHHHHHHHHHCCC	8.02	24043423
25	Phosphorylation	AGYLAQQYLPLPTPK HHHHHHHCCCCCCCC	9.75	24043423
30	Phosphorylation	QQYLPLPTPKVIGID HHCCCCCCCCEEEEE	43.34	24043423
41	O-linked_Glycosylation	IGIDLGTTYCSVGVF EEEECCCCEEEEEEE	22.26	OGP
105	Ubiquitination	DAKRFIGKIFTAEEL HHHHHHHHCCCHHHH	29.81	-
122	Acetylation	EIGRYPFKVLNKNGM HHCCCCEEEECCCCC	41.11	21339330
122	Ubiquitination	EIGRYPFKVLNKNGM HHCCCCEEEECCCCC	41.11	-
185	Phosphorylation	FDLKQRNSTIEAANL CCHHHCCCHHHHHHH	32.71	20068231
186	Phosphorylation	DLKQRNSTIEAANLA CHHHCCCHHHHHHHH	26.79	20068231
196	Ubiquitination	AANLAGLKILRVINE HHHHHCCEEEEECCC	38.48	-
205	O-linked_Glycosylation	LRVINEPTAAAMAYG EEECCCHHHHHHHHC	23.81	OGP
205	Phosphorylation	LRVINEPTAAAMAYG EEECCCHHHHHHHHC	23.81	-
211	Phosphorylation	PTAAAMAYGLHKADV HHHHHHHHCCHHHCE	13.72	-
234	Phosphorylation	GGGTLDVSLLNKQGG CCCEEEHHHEECCCC	27.14	24719451
249	Phosphorylation	MFLTRAMSGNNKLGG EEEEEECCCCCCCCC	37.07	20068231
253	Ubiquitination	RAMSGNNKLGGQDFN EECCCCCCCCCCCHH	53.13	-
266	Phosphorylation	FNQRLLQYLYKQIYQ HHHHHHHHHHHHHHH	16.39	29978859
268	Phosphorylation	QRLLQYLYKQIYQTY HHHHHHHHHHHHHHH	8.91	29978859
272	Phosphorylation	QYLYKQIYQTYGFVP HHHHHHHHHHHCCCC	7.72	20068231
274	Phosphorylation	LYKQIYQTYGFVPSR HHHHHHHHHCCCCCC	14.51	20068231
275	Phosphorylation	YKQIYQTYGFVPSRK HHHHHHHHCCCCCCH	7.95	20068231
280	Phosphorylation	QTYGFVPSRKEEIHR HHHCCCCCCHHHHHH	51.16	20068231
324	Phosphorylation	DRKEPHSSDTELPKD HCCCCCCCCCCCCHH	45.58	-
326	Phosphorylation	KEPHSSDTELPKDKL CCCCCCCCCCCHHHH	41.17	25159151
332	2-Hydroxyisobutyrylation	DTELPKDKLSSADDH CCCCCHHHHCCCCCC	57.29	-
347	Methylation	RVNSGFGRGLSDKKS CCCCCCCCCCCCCCC	40.39	115479907
357	Phosphorylation	SDKKSGESQVLFETE CCCCCCCCEEEEEHH	29.16	25137130
366	Phosphorylation	VLFETEISRKLFDTL EEEEHHHHHHHHHHC	19.68	25137130
368	Ubiquitination	FETEISRKLFDTLNE EEHHHHHHHHHHCCH	46.87	-
390	Ubiquitination	VPIQQVLKEGHLEKT HHHHHHHHHCCCCCC	63.89	-
424	Acetylation	VIQEFFGKDPNTSVD HHHHHHCCCCCCCCC	65.93	18507555
468	Phosphorylation	PNKHLQKTNFN---- CCHHHHCCCCC----	31.89	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSP13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSP13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSP13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBQL1_HUMAN	UBQLN1	physical	16189514
UBQL2_HUMAN	UBQLN2	physical	10675567
RMI1_HUMAN	RMI1	physical	21900206
DPOE4_HUMAN	POLE4	physical	21900206
SSRA_HUMAN	SSR1	physical	21900206
UBQL1_HUMAN	UBQLN1	physical	21988832
UBQL1_HUMAN	UBQLN1	physical	25416956
B4GT5_HUMAN	B4GALT5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.