DPP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DPP2_HUMAN
• UniProt AC: Q9UHL4
• Protein Name: Dipeptidyl peptidase 2
• Gene Name: DPP7
• Organism: Homo sapiens (Human).
• Sequence Length: 492
• Subcellular Localization: Lysosome . Cytoplasmic vesicle . Secreted .
• Protein Description: Plays an important role in the degradation of some oligopeptides..
• Protein Sequence: MGSAPWAPVLLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNKTFPQRFLVSDRFWVRGEGPIFFYTGNEGDVWAFANNSAFVAELAAERGALLVFAEHRYYGKSLPFGAQSTQRGHTELLTVEQALADFAELLRALRRDLGAQDAPAIAFGGSYGGMLSAYLRMKYPHLVAGALAASAPVLAVAGLGDSNQFFRDVTADFEGQSPKCTQGVREAFRQIKDLFLQGAYDTVRWEFGTCQPLSDEKDLTQLFMFARNAFTVLAMMDYPYPTDFLGPLPANPVKVGCDRLLSEAQRITGLRALAGLVYNASGSEHCYDIYRLYHSCADPTGCGTGPDARAWDYQACTEINLTFASNNVTDMFPDLPFTDELRQRYCLDTWGVWPRPDWLLTSFWGGDLRAASNIIFSNGNLDPWAGGGIRRNLSASVIAVTIQGGAHHLDLRASHPEDPASVVEARKLEATIIGEWVKAARREQQPALRGGPRLSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	N-linked_Glycosylation	FNFERFGNKTFPQRF CCHHHHCCCCCCCCE	37.17	19159218
86	N-linked_Glycosylation	GDVWAFANNSAFVAE CCEEEEECCHHHHHH	36.21	UniProtKB CARBOHYD
104	Ubiquitination	ERGALLVFAEHRYYG HCCCEEEEEECCCCC	7.14	21890473
112	Ubiquitination	AEHRYYGKSLPFGAQ EECCCCCCCCCCCCC	32.47	21906983
134	Ubiquitination	ELLTVEQALADFAEL EEECHHHHHHHHHHH	7.39	21890473
162	Phosphorylation	PAIAFGGSYGGMLSA CEEEECCCHHHHHHH	22.45	28348404
163	Phosphorylation	AIAFGGSYGGMLSAY EEEECCCHHHHHHHH	22.45	28348404
168	Phosphorylation	GSYGGMLSAYLRMKY CCHHHHHHHHHHHHC	13.13	28348404
170	Phosphorylation	YGGMLSAYLRMKYPH HHHHHHHHHHHHCHH	7.46	28348404
206	Phosphorylation	NQFFRDVTADFEGQS HHHHHHHHCCCCCCC	25.46	-
207	Ubiquitination	QFFRDVTADFEGQSP HHHHHHHCCCCCCCC	21.24	21963094
213	Phosphorylation	TADFEGQSPKCTQGV HCCCCCCCCCHHHHH	36.86	-
215	Ubiquitination	DFEGQSPKCTQGVRE CCCCCCCCHHHHHHH	55.98	21906983
220	Ubiquitination	SPKCTQGVREAFRQI CCCHHHHHHHHHHHH	3.43	21890473
228	Ubiquitination	REAFRQIKDLFLQGA HHHHHHHHHHHHCCC	39.79	21906983
237	Ubiquitination	LFLQGAYDTVRWEFG HHHCCCCCEEEEECC	37.89	21963094
238	Phosphorylation	FLQGAYDTVRWEFGT HHCCCCCEEEEECCC	10.17	-
250	Ubiquitination	FGTCQPLSDEKDLTQ CCCCCCCCCCCHHHH	50.86	21890473
288	Ubiquitination	LGPLPANPVKVGCDR CCCCCCCCCCCCHHH	29.43	21963094
301	Ubiquitination	DRLLSEAQRITGLRA HHHHHHHHHHHHHHH	33.00	21890473
304	Phosphorylation	LSEAQRITGLRALAG HHHHHHHHHHHHHHH	32.14	24719451
315	N-linked_Glycosylation	ALAGLVYNASGSEHC HHHHHEECCCCCCHH	21.83	16399764
315	N-linked_Glycosylation	ALAGLVYNASGSEHC HHHHHEECCCCCCHH	21.83	16399764
356	N-linked_Glycosylation	YQACTEINLTFASNN HHHCCEEEEEEECCC	27.14	UniProtKB CARBOHYD
363	N-linked_Glycosylation	NLTFASNNVTDMFPD EEEEECCCCCCCCCC	35.25	UniProtKB CARBOHYD
428	N-linked_Glycosylation	AGGGIRRNLSASVIA CCCHHHHCCCEEEEE	28.62	UniProtKB CARBOHYD
463	Ubiquitination	ASVVEARKLEATIIG HHHHHHHHHHHHHHH	58.70	-
474	Ubiquitination	TIIGEWVKAARREQQ HHHHHHHHHHHHHCC	37.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DPP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DPP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DPP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SBP1_HUMAN	SELENBP1	physical	22939629
MYCBP_HUMAN	MYCBP	physical	22939629
CYTB_HUMAN	CSTB	physical	22863883
PLCG1_HUMAN	PLCG1	physical	22863883
RIC8A_HUMAN	RIC8A	physical	22863883
SARNP_HUMAN	SARNP	physical	22863883
WDR61_HUMAN	WDR61	physical	22863883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-50 AND ASN-315, AND MASSSPECTROMETRY.
PubMed: 19159218