F234A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F234A_HUMAN
• UniProt AC: Q9H0X4
• Protein Name: Protein FAM234A
• Gene Name: FAM234A {ECO:0000312|HGNC:HGNC:14163}
• Organism: Homo sapiens (Human).
• Sequence Length: 552
• Subcellular Localization: Membrane ; Single-pass type II membrane protein .
• Protein Sequence: MLDHKDLEAEIHPLKNEERKSQENLGNPSKNEDNVKSAPPQSRLSRCRAAAFFLSLFLCLFVVFVVSFVIPCPDRPASQRMWRIDYSAAVIYDFLAVDDINGDRIQDVLFLYKNTNSSNNFSRSCVDEGFSSPCTFAAAVSGANGSTLWERPVAQDVALVECAVPQPRGSEAPSACILVGRPSSFIAVNLFTGETLWNHSSSFSGNASILSPLLQVPDVDGDGAPDLLVLTQEREEVSGHLYSGSTGHQIGLRGSLGVDGESGFLLHVTRTGAHYILFPCASSLCGCSVKGLYEKVTGSGGPFKSDPHWESMLNATTRRMLSHSSGAVRYLMHVPGNAGADVLLVGSEAFVLLDGQELTPRWTPKAAHVLRKPIFGRYKPDTLAVAVENGTGTDRQILFLDLGTGAVLCSLALPSLPGGPLSASLPTADHRSAFFFWGLHELGSTSETETGEARHSLYMFHPTLPRVLLELANVSTHIVAFDAVLFEPSRHAAYILLTGPADSEAPGLVSVIKHKVRDLVPSSRVVRLGEGGPDSDQAIRDRFSRLRYQSEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Ubiquitination	---MLDHKDLEAEIH ---CCCHHHHHHHCC		23000965
15 (in isoform 2)	Ubiquitination	-		21906983
15 (in isoform 1)	Ubiquitination	-		21906983
15	Ubiquitination	EAEIHPLKNEERKSQ HHHCCCCCCHHHHHH		21906983
20 (in isoform 2)	Ubiquitination	-		-
20	Ubiquitination	PLKNEERKSQENLGN CCCCHHHHHHHHCCC		21963094
21	Phosphorylation	LKNEERKSQENLGNP CCCHHHHHHHHCCCC		29255136
29	Phosphorylation	QENLGNPSKNEDNVK HHHCCCCCCCCCCCC		23403867
30 (in isoform 2)	Ubiquitination	-		21906983
30 (in isoform 1)	Ubiquitination	-		21906983
30	Ubiquitination	ENLGNPSKNEDNVKS HHCCCCCCCCCCCCC		21963094
36 (in isoform 2)	Ubiquitination	-		-
36	Ubiquitination	SKNEDNVKSAPPQSR CCCCCCCCCCCCHHH		33845483
86	Phosphorylation	QRMWRIDYSAAVIYD HCCEEEECCHHHHHH		27811184
87	Phosphorylation	RMWRIDYSAAVIYDF CCEEEECCHHHHHHE		27811184
92	Phosphorylation	DYSAAVIYDFLAVDD ECCHHHHHHEEEECC		27811184
116	N-linked_Glycosylation	LFLYKNTNSSNNFSR EEEEECCCCCCCCCH		UniProtKB CARBOHYD
119	N-linked_Glycosylation	YKNTNSSNNFSRSCV EECCCCCCCCCHHHC		-
119	N-linked_Glycosylation	YKNTNSSNNFSRSCV EECCCCCCCCCHHHC		19349973
243	Phosphorylation	EVSGHLYSGSTGHQI EECCEECCCCCCCEE		-
255	Phosphorylation	HQIGLRGSLGVDGES CEEEECCEECCCCCC		-
314	N-linked_Glycosylation	PHWESMLNATTRRML HHHHHHHHHHHHHHH		19349973
365	Ubiquitination	LTPRWTPKAAHVLRK CCCCCCCCHHHHHCC		-
389	N-linked_Glycosylation	TLAVAVENGTGTDRQ CEEEEEECCCCCCCE		19349973
391	Phosphorylation	AVAVENGTGTDRQIL EEEEECCCCCCCEEE		-
393	Phosphorylation	AVENGTGTDRQILFL EEECCCCCCCEEEEE		-
473	N-linked_Glycosylation	RVLLELANVSTHIVA HHHHHHCCCCCEEEE		19349973
489	Phosphorylation	DAVLFEPSRHAAYIL EEEEECCCCCEEEEE		-
498 (in isoform 2)	Phosphorylation	-		22210691
510 (in isoform 2)	Phosphorylation	-		22210691
522	O-linked_Glycosylation	KVRDLVPSSRVVRLG HHHHHCCCCCEEECC		29237092
523	O-linked_Glycosylation	VRDLVPSSRVVRLGE HHHHCCCCCEEECCC		29237092

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F234A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F234A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F234A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of F234A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.