MGAT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGAT3_HUMAN
• UniProt AC: Q09327
• Protein Name: Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
• Gene Name: MGAT3
• Organism: Homo sapiens (Human).
• Sequence Length: 533
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides..
• Protein Sequence: MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQASPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPEDTTEYFVRTKAGGVCFKPGTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTGGRGARRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEFDLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRGLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDRFHYLLDNPYQEPRSTAAGGWRHRGPEGRPPARGKLDEAEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	O-linked_Glycosylation	APVTPQASPEPGGPD CCCCCCCCCCCCCCC	25.25	OGP
123	Acetylation	VCFKPGTKMLERPPP EEECCCCCCCCCCCC	47.61	19826817
141	N-linked_Glycosylation	EEKPEGANGSSARRP CCCCCCCCCCCCCCC	62.83	UniProtKB CARBOHYD
154	Phosphorylation	RPPRYLLSARERTGG CCCCEEEEHHHHHCC	23.76	24719451
241	N-linked_Glycosylation	AFVVCESNFTAYGEP EEEEECCCCCCCCCC	18.92	UniProtKB CARBOHYD
259	N-linked_Glycosylation	KFREMLTNGTFEYIR CHHHHHHCCCHHHHH	43.47	UniProtKB CARBOHYD
264	Phosphorylation	LTNGTFEYIRHKVLY HHCCCHHHHHHHHHE	10.08	-
397	N-linked_Glycosylation	PNFRQYENRTGHILV CCCCCCCCCCCEEEE	41.71	UniProtKB CARBOHYD
489	Ubiquitination	YAPKYLLKNYDRFHY CCCHHHHHCCCHHHH	51.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MGAT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MGAT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGAT3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MGAT3_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.