| UniProt ID | NRROS_HUMAN | |
|---|---|---|
| UniProt AC | Q86YC3 | |
| Protein Name | Negative regulator of reactive oxygen species | |
| Gene Name | NRROS | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 692 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein . Endoplasmic reticulum membrane Single-pass type I membrane protein. |
|
| Protein Description | Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.. | |
| Protein Sequence | MELLPLWLCLGFHFLTVGWRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGALQHGQTVADWAMVTCNLSSKIIRVTELPGGVPRDCKWERLDLGLLYLVLILPSCLTLLVACTVIVLTFKKPLLQVIKSRCHWSSVY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of NRROS_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NRROS_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NRROS_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NRROS_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MARK3_HUMAN | MARK3 | physical | 28514442 | |
| MARK2_HUMAN | MARK2 | physical | 28514442 | |
| CNPY3_HUMAN | CNPY3 | physical | 28514442 | |
| R4RL2_HUMAN | RTN4RL2 | physical | 28514442 | |
| NDST1_HUMAN | NDST1 | physical | 28514442 | |
| CALX_HUMAN | CANX | physical | 28514442 | |
| LIGO1_HUMAN | LINGO1 | physical | 28514442 | |
| TGFB1_HUMAN | TGFB1 | physical | 28514442 | |
| IPRI_HUMAN | ITPRIP | physical | 28514442 | |
| NDUA3_HUMAN | NDUFA3 | physical | 28514442 | |
| EPHB4_HUMAN | EPHB4 | physical | 28514442 | |
| ALG9_HUMAN | ALG9 | physical | 28514442 | |
| SDF2L_HUMAN | SDF2L1 | physical | 28514442 | |
| POMT1_HUMAN | POMT1 | physical | 28514442 | |
| GRP78_HUMAN | HSPA5 | physical | 28514442 | |
| EXT1_HUMAN | EXT1 | physical | 28514442 | |
| DEFM_HUMAN | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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