R4RL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: R4RL2_HUMAN
• UniProt AC: Q86UN3
• Protein Name: Reticulon-4 receptor-like 2
• Gene Name: RTN4RL2 {ECO:0000312|HGNC:HGNC:23053}
• Organism: Homo sapiens (Human).
• Sequence Length: 420
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor . Membrane raft . Cell projection, dendrite . Perikaryon . Cell projection, axon . Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses.
• Protein Description: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. [PubMed: 22325200 Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton]
• Protein Sequence: MLPGLRRLLQAPASACLLLMLLALPLAAPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGSNLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALREADFQACPPAAPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPAEDSRGRQGGDAPTEDDYWGGYGGEDQRGEQMCPGAACQAPPDSRGPALSAGLPSPLLCLLLLVPHHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	N-linked_Glycosylation	TVSCQANNFSSVPLS CEEECCCCCCCCCCC	40.99	UniProtKB CARBOHYD
93	N-linked_Glycosylation	TLWLFSNNLSTIYPG HHHHHCCCCCCCCCC	33.88	-
139	Phosphorylation	RLQSLHLYRCQLSSL HHHHHCEEECHHHCC	9.90	21403953
236	N-linked_Glycosylation	LTILYLFNNSLASLP HHHHHHHCCCCCCCC	34.29	-
290	Phosphorylation	SSDVTCATPPERQGR CCCCCCCCCHHHCCC	41.33	-
316	O-linked_Glycosylation	ACPPAAPTRPGSRAR CCCCCCCCCCCCCCC	44.78	31006399
370	Phosphorylation	DAPTEDDYWGGYGGE CCCCCCCCCCCCCCC	20.48	28985074
374	Phosphorylation	EDDYWGGYGGEDQRG CCCCCCCCCCCCCCC	20.30	28985074
390	GPI-anchor	QMCPGAACQAPPDSR EECCCCCCCCCCCCC	3.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of R4RL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of R4RL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of R4RL2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of R4RL2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.