ENPP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ENPP3_HUMAN
• UniProt AC: O14638
• Protein Name: Ectonucleotide pyrophosphatase/phosphodiesterase family member 3
• Gene Name: ENPP3
• Organism: Homo sapiens (Human).
• Sequence Length: 875
• Subcellular Localization: Membrane ; Single-pass type II membrane protein . Secreted . Located to the apical surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma membrane of bile duct cells. Secreted in serum, a
• Protein Description: Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD..
• Protein Sequence: MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MESTLTLATE -----CCCCCEECCC	27.67	23401153
4	Phosphorylation	----MESTLTLATEQ ----CCCCCEECCCC	15.51	23663014
6	Phosphorylation	--MESTLTLATEQPV --CCCCCEECCCCCC	17.90	23663014
9	Phosphorylation	ESTLTLATEQPVKKN CCCCEECCCCCCCCC	37.96	23663014
196	Phosphorylation	TCGIHSKYMRAMYPT CCCCCHHHHHHHCCC	8.54	25852190
201	Phosphorylation	SKYMRAMYPTKTFPN HHHHHHHCCCCCCCC	13.53	25852190
203	Phosphorylation	YMRAMYPTKTFPNHY HHHHHCCCCCCCCCE	25.81	28857561
205	Phosphorylation	RAMYPTKTFPNHYTI HHHCCCCCCCCCEEE	46.96	28857561
211	Phosphorylation	KTFPNHYTIVTGLYP CCCCCCEEEEEECCC	11.04	28857561
236	N-linked_Glycosylation	YDVNLNKNFSLSSKE EEECCCCCCCCCCCC	30.57	29717535
279	N-linked_Glycosylation	PGSEVAINGSFPSIY CCCEEEECCCCCCCC	30.25	29717535
290	N-linked_Glycosylation	PSIYMPYNGSVPFEE CCCCCCCCCCCCHHH	30.32	29717535
300	Phosphorylation	VPFEERISTLLKWLD CCHHHHHHHHHHHHC	21.15	23403867
301	Phosphorylation	PFEERISTLLKWLDL CHHHHHHHHHHHHCC	33.47	23403867
389	Phosphorylation	KMEYMTDYFPRINFF HHHHHHHHCCCCCEE	13.30	-
420	Phosphorylation	HDFFSFNSEEIVRNL CCCCCCCHHHHHHHH	34.30	28857561
426	N-linked_Glycosylation	NSEEIVRNLSCRKPD CHHHHHHHHCCCCCC	25.97	29717535
533	N-linked_Glycosylation	RIQPAPNNGTHGSLN CCCCCCCCCCCCCCH	56.53	29717535
582	N-linked_Glycosylation	CFCPHLQNSTQLEQV HCCHHCCCCHHHHHH	54.08	29717535
594	N-linked_Glycosylation	EQVNQMLNLTQEEIT HHHHHHHCCCHHHHH	35.38	29717535
687	N-linked_Glycosylation	SFYLADKNITHGFLY EEEEECCCCCCCEEC	44.96	29717535
689	Phosphorylation	YLADKNITHGFLYPP EEECCCCCCCEECCC	25.91	-
694	Phosphorylation	NITHGFLYPPASNRT CCCCCEECCCCCCCC	12.62	-
699	N-linked_Glycosylation	FLYPPASNRTSDSQY EECCCCCCCCCHHHH	54.04	29717535
727	Phosphorylation	EFRKMWDYFHSVLLI HHHHHHHHHHHHHHH	6.41	29116813
755	Phosphorylation	GPIFDYNYDGHFDAP CCCCCCCCCCCCCCC	19.64	22817900
789	N-linked_Glycosylation	VVLTSCKNKSHTPEN EEEEECCCCCCCCCC	56.22	29717535
846	Phosphorylation	VRDVELLTGLDFYQD HHCHHHHHCCCCCCC	48.61	22817900
851	Phosphorylation	LLTGLDFYQDKVQPV HHHCCCCCCCCCCCH	18.57	22817900
867	Phosphorylation	EILQLKTYLPTFETT HHHHHHHHCCCCCCC	14.75	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
205	T	Phosphorylation	Kinase	ENPP3	O14638	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ENPP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ENPP3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ENPP3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.