PLVAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLVAP_HUMAN
• UniProt AC: Q9BX97
• Protein Name: Plasmalemma vesicle-associated protein
• Gene Name: PLVAP
• Organism: Homo sapiens (Human).
• Sequence Length: 442
• Subcellular Localization: Cell membrane ; Single-pass type II membrane protein . Membrane, caveola ; Single-pass type II membrane protein . Cytoplasm, perinuclear region . Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endot
• Protein Description: Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability..
• Protein Sequence: MGLAMEHGGSYARAGGSSRGCWYYLRYFFLFVSLIQFLIILGLVLFMVYGNVHVSTESNLQATERRAEGLYSQLLGLTASQSNLTKELNFTTRAKDAIMQMWLNARRDLDRINASFRQCQGDRVIYTNNQRYMAAIILSEKQCRDQFKDMNKSCDALLFMLNQKVKTLEVEIAKEKTICTKDKESVLLNKRVAEEQLVECVKTRELQHQERQLAKEQLQKVQALCLPLDKDKFEMDLRNLWRDSIIPRSLDNLGYNLYHPLGSELASIRRACDHMPSLMSSKVEELARSLRADIERVARENSDLQRQKLEAQQGLRASQEAKQKVEKEAQAREAKLQAECSRQTQLALEEKAVLRKERDNLAKELEEKKREAEQLRMELAIRNSALDTCIKTKSQPMMPVSRPMGPVPNPQPIDPASLEEFKRKILESQRPPAGIPVAPSSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	LAMEHGGSYARAGGS CCCCCCCCCCCCCCC	21.88	28857561
11	Phosphorylation	AMEHGGSYARAGGSS CCCCCCCCCCCCCCC	11.90	21253578
71	Phosphorylation	ERRAEGLYSQLLGLT HHHHHHHHHHHHCCC	12.77	29759185
72	Phosphorylation	RRAEGLYSQLLGLTA HHHHHHHHHHHCCCC	21.28	29759185
78	Phosphorylation	YSQLLGLTASQSNLT HHHHHCCCCCCCCCC	23.59	29759185
83	N-linked_Glycosylation	GLTASQSNLTKELNF CCCCCCCCCCHHCCC	44.06	UniProtKB CARBOHYD
89	N-linked_Glycosylation	SNLTKELNFTTRAKD CCCCHHCCCCHHHHH	33.05	UniProtKB CARBOHYD
113	N-linked_Glycosylation	RRDLDRINASFRQCQ HHCHHHHCHHHHHHC	30.35	UniProtKB CARBOHYD
132	Phosphorylation	IYTNNQRYMAAIILS EECCCHHHEEEHHHC	4.95	29396449
139	Phosphorylation	YMAAIILSEKQCRDQ HEEEHHHCHHHHHHH	32.13	24719451
151	N-linked_Glycosylation	RDQFKDMNKSCDALL HHHHHHHHHHHHHHH	43.13	UniProtKB CARBOHYD
267	Phosphorylation	PLGSELASIRRACDH CCCHHHHHHHHHHHC	29.29	24719451
289	Phosphorylation	KVEELARSLRADIER HHHHHHHHHHHHHHH	19.32	23312004
318	Phosphorylation	AQQGLRASQEAKQKV HHHHHHHHHHHHHHH	23.32	29759185
327	Ubiquitination	EAKQKVEKEAQAREA HHHHHHHHHHHHHHH	62.43	29967540
401	O-linked_Glycosylation	SQPMMPVSRPMGPVP CCCCCCCCCCCCCCC	25.46	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLVAP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLVAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLVAP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NRP1_HUMAN	NRP1	physical	22627768
FUT8_HUMAN	FUT8	physical	26186194
NSMA_HUMAN	SMPD2	physical	26186194
ZDHC6_HUMAN	ZDHHC6	physical	26186194
LMA2L_HUMAN	LMAN2L	physical	26186194
OSB11_HUMAN	OSBPL11	physical	26186194
VGFR3_HUMAN	FLT4	physical	26186194
ZDHC6_HUMAN	ZDHHC6	physical	28514442
NSMA_HUMAN	SMPD2	physical	28514442
OSB11_HUMAN	OSBPL11	physical	28514442
FUT8_HUMAN	FUT8	physical	28514442
LMA2L_HUMAN	LMAN2L	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.