RASL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RASL1_HUMAN
• UniProt AC: O95294
• Protein Name: RasGAP-activating-like protein 1 {ECO:0000305}
• Gene Name: RASAL1 {ECO:0000312|HGNC:HGNC:9873}
• Organism: Homo sapiens (Human).
• Sequence Length: 804
• Protein Description: Probable inhibitory regulator of the Ras-cyclic AMP pathway. [PubMed: 9751798 Plays a role in dendrite formation by melanocytes]
• Protein Sequence: MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDRAHEEFQQQERGKAALGPLGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAKSSSLNVRV ----CCCCCCCCEEE	18.67	23186163
5	Phosphorylation	---MAKSSSLNVRVV ---CCCCCCCCEEEE	37.83	23186163
6	Phosphorylation	--MAKSSSLNVRVVE --CCCCCCCCEEEEE	30.93	23186163
20	Ubiquitination	EGRALPAKDVSGSSD ECCCCCCCCCCCCCC	57.64	29967540
44	Phosphorylation	EVVARTATVWRSLGP HHHHHHHHHHHHCCC	21.71	-
88	Phosphorylation	DDIIGKISLSREAIT CCCCCEEEECCHHHC	24.63	24719451
146	Ubiquitination	VLQARDLAPRDISGT EEECCCCCCCCCCCC	11.02	22817900
151	Phosphorylation	DLAPRDISGTSDPFA CCCCCCCCCCCCCCH	40.06	22210691
153	Phosphorylation	APRDISGTSDPFARV CCCCCCCCCCCCHHH	24.14	22210691
154	Phosphorylation	PRDISGTSDPFARVF CCCCCCCCCCCHHHH	46.97	22210691
174	Ubiquitination	LETSTIKKTRFPHWD CCCCCCCCCCCCCHH	40.87	-
218	Phosphorylation	FLGMVEFSPKTLQQK EECEEEECCCHHCCC	16.39	24076635
243	Phosphorylation	FPRAEEDSGGNLGAL CCCCCCCCCCCCCCC	52.45	27251275
308	Ubiquitination	CRQDLATKLVKLFLG HHHHHHHHHHHHHHH	45.75	29967540
349	Ubiquitination	RSNSLASKSMEQFMK CCCCHHCCCHHHHHH	48.49	-
393	Phosphorylation	CKMDLGRTRRISFKG CCCCCCCCEEEECCC	23.62	23882029
397	Phosphorylation	LGRTRRISFKGALSE CCCCEEEECCCCCCH	21.06	23882029
399	Ubiquitination	RTRRISFKGALSEEQ CCEEEECCCCCCHHH	36.16	-
399	Methylation	RTRRISFKGALSEEQ CCEEEECCCCCCHHH	36.16	98666335
482	Ubiquitination	APAILTPKLFDLRDQ HHHHHCHHHHCCCHH	57.46	-
504 (in isoform 1)	Ubiquitination	-	49.40	21906983
504 (in isoform 2)	Ubiquitination	-	49.40	21906983
504	Ubiquitination	RSLLLLAKAVQSIGN HHHHHHHHHHHHHHH	49.40	22817900
505	Ubiquitination	SLLLLAKAVQSIGNL HHHHHHHHHHHHHHH	10.04	22817900
571	Phosphorylation	SAIVREGYLLKRKEE HHHHHCCEEECCCCC	12.24	27461979
574	Ubiquitination	VREGYLLKRKEEPAG HHCCEEECCCCCCCC	59.85	-
574	Acetylation	VREGYLLKRKEEPAG HHCCEEECCCCCCCC	59.85	25953088
576	Ubiquitination	EGYLLKRKEEPAGLA CCEEECCCCCCCCHH	65.91	-
601	Phosphorylation	WLSGETLSFSKSPEW EECCCEEECCCCCCH	34.59	24719451
605 (in isoform 2)	Phosphorylation	-	27.18	26503514
616 (in isoform 2)	Phosphorylation	-	6.57	26503514
621 (in isoform 2)	Phosphorylation	-	13.61	26503514
622 (in isoform 2)	Phosphorylation	-	3.29	26503514
623 (in isoform 2)	Phosphorylation	-	46.10	26503514
758	Phosphorylation	DTTLEADTGACPEVL CCCEECCCCCCHHHH	33.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RASL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RASL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RASL1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RASL1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.