RGSL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGSL_HUMAN
• UniProt AC: A5PLK6
• Protein Name: Regulator of G-protein signaling protein-like
• Gene Name: RGSL1
• Organism: Homo sapiens (Human).
• Sequence Length: 1076
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MSSAEIIGSTNLIILLEDEVFADFFNTFLSLPVFGQTPFYTVENSQWSLWPEIPCNLIAKYKGLLTWLEKCRLPFFCKTNLCFHYILCQEFISFIKSPEGGEELVDFWILAENILSIDEMDLEVRDYYLSLLLMLRATHLQEGSRVVTLCNMNIKSLLNLSIWHPNQSTTRREILSHMQKVALFKLQSYWLPNFYTHTKMTMAKEEACHGLMQEYETRLYSVCYTHIGGLPLNMSIKKCHHFQKRYSSRKAKRKMWQLVDPDSWSLEMDLKPDAIGMPLQETCPQEKVVIQMPSLKMASSKETRISSLEKDMHYAKISSMENKAKSHLHMEAPFETKVSTHLRTVIPIVNHSSKMTIQKAIKQSFSLGYIHLALCADACAGNPFRDHLKKLNLKVEIQLLDLWQDLQHFLSVLLNNKKNGNAIFRHLLGDRICELYLNEQIGPCLPLKSQTIQGLKELLPSGDVIPWIPKAQKEICKMLSPWYDEFLDEEDYWFLLFTTQNRFISSRQHKREFIGKEENILLYKRIQQSLELSQALADMKEMDYRQWRKIATEDLKQGGSLQVELTSPVFLTDITKMSFEELCYKNPKMAIQKISDDYKIYCEKAPKIDFKMEIIKETKTVSRSNRKMSLLKRTLVRKPSMRPRNLTEVLLNTQHLEFFREFLKERKAKIPLQFLTAVQKISIETNEKICKSLIENVIKTFFQGQLSPEEMLQCDAPIIKEIASMRHVTTSTLLTLQGHVMKSIEEKWFKDYQDLFPPHHQEVEVQSEVQISSRKPSKIVSTYLQESQKKGWMRMISFIRSFCKYRRFMLNPSKRQEFEDYLHQEMQNSKENFTTAHNTSGRSAPPSTNVRSADQENGEITLVKRRIFGHRIITVNFAINDLYFFSEMEKFNDLVSSAHMLQVNRAYNENDVILMRSKMNIIQKLFLNSDIPPKLRVNVPEFQKDAILAAITEGYLDRSVFHGAIMSVFPVVMYFWKRFCFWKATRSYLQYRGKKFKDRKSPPKSTDKYPFSSGGDNAILRFTLLRGIEWLQPQREAISSVQNSSSSKLTQPRLVVSAMQLHPVQGQKLSYIKKEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 5)	Phosphorylation	-	41.60	29507054
3 (in isoform 2)	Phosphorylation	-	41.60	29507054
93	Phosphorylation	ILCQEFISFIKSPEG HHHHHHHHHHCCCCC	26.66	24719451
130	Phosphorylation	EVRDYYLSLLLMLRA HHHHHHHHHHHHHHH	10.80	-
144	Phosphorylation	ATHLQEGSRVVTLCN HHHCCCCCEEEEEEC	22.58	30622161
148	Phosphorylation	QEGSRVVTLCNMNIK CCCCEEEEEECCCHH	23.80	30622161
176	Phosphorylation	TTRREILSHMQKVAL HHHHHHHHHHHHHHH	23.68	22210691
237	Ubiquitination	LPLNMSIKKCHHFQK EECCCCHHHHHHHHH	41.88	32015554
272	Ubiquitination	SLEMDLKPDAIGMPL CCCCCCCCCCCCCCH	43.49	32015554
316	Acetylation	EKDMHYAKISSMENK HHHHHHHHHHHHCHH	35.63	7664633
323	Acetylation	KISSMENKAKSHLHM HHHHHCHHHHHHCCC	43.83	7664641
449	Phosphorylation	GPCLPLKSQTIQGLK CCCCCCCCCCHHHHH	39.99	-
451	Phosphorylation	CLPLKSQTIQGLKEL CCCCCCCCHHHHHHH	23.51	-
480	Phosphorylation	KEICKMLSPWYDEFL HHHHHHHCHHHHHHC	15.19	23663014
483	Phosphorylation	CKMLSPWYDEFLDEE HHHHCHHHHHHCCCC	14.69	23663014
492	Phosphorylation	EFLDEEDYWFLLFTT HHCCCCCEEEEEEEC	11.01	23663014
498	Phosphorylation	DYWFLLFTTQNRFIS CEEEEEEECCCCCCC	27.69	23663014
499	Phosphorylation	YWFLLFTTQNRFISS EEEEEEECCCCCCCC	19.26	23663014
529	Phosphorylation	LYKRIQQSLELSQAL HHHHHHHHHHHHHHH	13.87	-
578	Phosphorylation	LTDITKMSFEELCYK CCCHHHCCHHHHHHH	30.94	23663014
584	Phosphorylation	MSFEELCYKNPKMAI CCHHHHHHHCHHHHH	26.82	23663014
629	Phosphorylation	SRSNRKMSLLKRTLV CCHHHHHHHHHHHHC	33.32	24719451
692	Phosphorylation	TNEKICKSLIENVIK CCHHHHHHHHHHHHH	30.12	27251275
907	Phosphorylation	MLQVNRAYNENDVIL HHHHHCCCCCCCEEE	21.55	22210691
1009	Phosphorylation	PPKSTDKYPFSSGGD CCCCCCCCCCCCCCC	16.60	-
1057	Phosphorylation	TQPRLVVSAMQLHPV CCCEEEEEEEECCCC	15.56	25693802

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGSL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGSL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGSL_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RGSL_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.