UniProt ID | STAC3_HUMAN | |
---|---|---|
UniProt AC | Q96MF2 | |
Protein Name | SH3 and cysteine-rich domain-containing protein 3 | |
Gene Name | STAC3 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 364 | |
Subcellular Localization |
Cytoplasm . Cell membrane, sarcolemma Peripheral membrane protein Cytoplasmic side . Co-localizes with CACNA1S and CACNA1C on T-tubules (extensions of the sarcolemma). |
|
Protein Description | Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. [PubMed: 23736855] | |
Protein Sequence | MTEKEVLESPKPSFPAETRQSGLQRLKQLLRKGSTGTKEMELPPEPQANGEAVGAGGGPIYYIYEEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKDLSAANRNDPVFETLRTGVIMANKERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
9 | Phosphorylation | TEKEVLESPKPSFPA CHHHHHHCCCCCCCH | 33.78 | 24719451 | |
18 | Phosphorylation | KPSFPAETRQSGLQR CCCCCHHHHHHHHHH | 35.79 | 29116813 | |
21 | Phosphorylation | FPAETRQSGLQRLKQ CCHHHHHHHHHHHHH | 37.87 | 26437602 | |
34 | Phosphorylation | KQLLRKGSTGTKEME HHHHHCCCCCCCCCC | 27.05 | 26437602 | |
37 | Phosphorylation | LRKGSTGTKEMELPP HHCCCCCCCCCCCCC | 24.74 | - | |
152 | Phosphorylation | PPGFHRAYSSPLYSN CCCCHHCCCCCCCCC | 15.05 | 29209046 | |
153 | Phosphorylation | PGFHRAYSSPLYSNQ CCCHHCCCCCCCCCC | 25.21 | 29209046 | |
154 | Phosphorylation | GFHRAYSSPLYSNQQ CCHHCCCCCCCCCCC | 13.27 | 29209046 | |
157 | Phosphorylation | RAYSSPLYSNQQYAC HCCCCCCCCCCCEEH | 14.68 | 29209046 | |
158 | Phosphorylation | AYSSPLYSNQQYACV CCCCCCCCCCCEEHH | 35.53 | 29209046 | |
162 | Phosphorylation | PLYSNQQYACVKDLS CCCCCCCEEHHHHHH | 7.69 | 29209046 | |
183 | Phosphorylation | PVFETLRTGVIMANK HHHHHHHHCEECCCC | 38.62 | - |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of STAC3_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of STAC3_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of STAC3_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
STAC3_HUMAN | STAC3 | physical | 16189514 | |
JMJD6_HUMAN | JMJD6 | physical | 23455924 | |
NSD3_HUMAN | WHSC1L1 | physical | 23455924 | |
STAC3_HUMAN | STAC3 | physical | 25416956 | |
SR1IP_HUMAN | SREK1IP1 | physical | 25416956 | |
F133A_HUMAN | FAM133A | physical | 25416956 | |
T2FA_HUMAN | GTF2F1 | physical | 26186194 | |
ANKL2_HUMAN | ANKLE2 | physical | 26186194 | |
WDR54_HUMAN | WDR54 | physical | 26186194 | |
MMTA2_HUMAN | C1orf35 | physical | 21516116 | |
ENKD1_HUMAN | ENKD1 | physical | 21516116 | |
EAF1_HUMAN | EAF1 | physical | 21516116 | |
ANKL2_HUMAN | ANKLE2 | physical | 28514442 | |
WDR54_HUMAN | WDR54 | physical | 28514442 | |
T2FA_HUMAN | GTF2F1 | physical | 28514442 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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