STAC3_HUMAN - dbPTM
STAC3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STAC3_HUMAN
UniProt AC Q96MF2
Protein Name SH3 and cysteine-rich domain-containing protein 3
Gene Name STAC3
Organism Homo sapiens (Human).
Sequence Length 364
Subcellular Localization Cytoplasm . Cell membrane, sarcolemma
Peripheral membrane protein
Cytoplasmic side . Co-localizes with CACNA1S and CACNA1C on T-tubules (extensions of the sarcolemma).
Protein Description Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. [PubMed: 23736855]
Protein Sequence MTEKEVLESPKPSFPAETRQSGLQRLKQLLRKGSTGTKEMELPPEPQANGEAVGAGGGPIYYIYEEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKDLSAANRNDPVFETLRTGVIMANKERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationTEKEVLESPKPSFPA
CHHHHHHCCCCCCCH
33.7824719451
18PhosphorylationKPSFPAETRQSGLQR
CCCCCHHHHHHHHHH
35.7929116813
21PhosphorylationFPAETRQSGLQRLKQ
CCHHHHHHHHHHHHH
37.8726437602
34PhosphorylationKQLLRKGSTGTKEME
HHHHHCCCCCCCCCC
27.0526437602
37PhosphorylationLRKGSTGTKEMELPP
HHCCCCCCCCCCCCC
24.74-
152PhosphorylationPPGFHRAYSSPLYSN
CCCCHHCCCCCCCCC
15.0529209046
153PhosphorylationPGFHRAYSSPLYSNQ
CCCHHCCCCCCCCCC
25.2129209046
154PhosphorylationGFHRAYSSPLYSNQQ
CCHHCCCCCCCCCCC
13.2729209046
157PhosphorylationRAYSSPLYSNQQYAC
HCCCCCCCCCCCEEH
14.6829209046
158PhosphorylationAYSSPLYSNQQYACV
CCCCCCCCCCCEEHH
35.5329209046
162PhosphorylationPLYSNQQYACVKDLS
CCCCCCCEEHHHHHH
7.6929209046
183PhosphorylationPVFETLRTGVIMANK
HHHHHHHHCEECCCC
38.62-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STAC3_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STAC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STAC3_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STAC3_HUMANSTAC3physical
16189514
JMJD6_HUMANJMJD6physical
23455924
NSD3_HUMANWHSC1L1physical
23455924
STAC3_HUMANSTAC3physical
25416956
SR1IP_HUMANSREK1IP1physical
25416956
F133A_HUMANFAM133Aphysical
25416956
T2FA_HUMANGTF2F1physical
26186194
ANKL2_HUMANANKLE2physical
26186194
WDR54_HUMANWDR54physical
26186194
MMTA2_HUMANC1orf35physical
21516116
ENKD1_HUMANENKD1physical
21516116
EAF1_HUMANEAF1physical
21516116
ANKL2_HUMANANKLE2physical
28514442
WDR54_HUMANWDR54physical
28514442
T2FA_HUMANGTF2F1physical
28514442

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STAC3_HUMAN

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Related Literatures of Post-Translational Modification

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