STAC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STAC3_HUMAN
• UniProt AC: Q96MF2
• Protein Name: SH3 and cysteine-rich domain-containing protein 3
• Gene Name: STAC3
• Organism: Homo sapiens (Human).
• Sequence Length: 364
• Subcellular Localization: Cytoplasm . Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Co-localizes with CACNA1S and CACNA1C on T-tubules (extensions of the sarcolemma).
• Protein Description: Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. [PubMed: 23736855]
• Protein Sequence: MTEKEVLESPKPSFPAETRQSGLQRLKQLLRKGSTGTKEMELPPEPQANGEAVGAGGGPIYYIYEEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKDLSAANRNDPVFETLRTGVIMANKERKKGQADKKNPVAAMMEEEPESARPEEGKPQDGNPEGDKKAEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDEAGGYVKVYTGRKVGLFPTDFLEEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	TEKEVLESPKPSFPA CHHHHHHCCCCCCCH	33.78	24719451
18	Phosphorylation	KPSFPAETRQSGLQR CCCCCHHHHHHHHHH	35.79	29116813
21	Phosphorylation	FPAETRQSGLQRLKQ CCHHHHHHHHHHHHH	37.87	26437602
34	Phosphorylation	KQLLRKGSTGTKEME HHHHHCCCCCCCCCC	27.05	26437602
37	Phosphorylation	LRKGSTGTKEMELPP HHCCCCCCCCCCCCC	24.74	-
152	Phosphorylation	PPGFHRAYSSPLYSN CCCCHHCCCCCCCCC	15.05	29209046
153	Phosphorylation	PGFHRAYSSPLYSNQ CCCHHCCCCCCCCCC	25.21	29209046
154	Phosphorylation	GFHRAYSSPLYSNQQ CCHHCCCCCCCCCCC	13.27	29209046
157	Phosphorylation	RAYSSPLYSNQQYAC HCCCCCCCCCCCEEH	14.68	29209046
158	Phosphorylation	AYSSPLYSNQQYACV CCCCCCCCCCCEEHH	35.53	29209046
162	Phosphorylation	PLYSNQQYACVKDLS CCCCCCCEEHHHHHH	7.69	29209046
183	Phosphorylation	PVFETLRTGVIMANK HHHHHHHHCEECCCC	38.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STAC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STAC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STAC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STAC3_HUMAN	STAC3	physical	16189514
JMJD6_HUMAN	JMJD6	physical	23455924
NSD3_HUMAN	WHSC1L1	physical	23455924
STAC3_HUMAN	STAC3	physical	25416956
SR1IP_HUMAN	SREK1IP1	physical	25416956
F133A_HUMAN	FAM133A	physical	25416956
T2FA_HUMAN	GTF2F1	physical	26186194
ANKL2_HUMAN	ANKLE2	physical	26186194
WDR54_HUMAN	WDR54	physical	26186194
MMTA2_HUMAN	C1orf35	physical	21516116
ENKD1_HUMAN	ENKD1	physical	21516116
EAF1_HUMAN	EAF1	physical	21516116
ANKL2_HUMAN	ANKLE2	physical	28514442
WDR54_HUMAN	WDR54	physical	28514442
T2FA_HUMAN	GTF2F1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.