GCSAM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCSAM_HUMAN
• UniProt AC: Q8N6F7
• Protein Name: Germinal center-associated signaling and motility protein
• Gene Name: GCSAM
• Organism: Homo sapiens (Human).
• Sequence Length: 178
• Subcellular Localization: Cytoplasm. Cell membrane. It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
• Protein Description: Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation..
• Protein Sequence: MGNSLLRENRRQQNTQEMPWNVRMQSPKQRTSRCWDHHIAEGCFCLPWKKILIFEKRQDSQNENERMSSTPIQDNVDQTYSEELCYTLINHRVLCTRPSGNSAEEYYENVPCKAERPRESLGGTETEYSLLHMPSTDPRHARSPEDEYELLMPHRISSHFLQQPRPLMAPSETQFSHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	ENRRQQNTQEMPWNV HHHHHHCCCCCCCCC		26714015
56	Ubiquitination	KKILIFEKRQDSQNE HEEEEEEECCCCCCC		29967540
58	Ubiquitination	ILIFEKRQDSQNENE EEEEEECCCCCCCCH		29967540
60	Phosphorylation	IFEKRQDSQNENERM EEEECCCCCCCCHHH		20164059
68	Phosphorylation	QNENERMSSTPIQDN CCCCHHHCCCCCCCC		27080861
69	Phosphorylation	NENERMSSTPIQDNV CCCHHHCCCCCCCCC		30108239
70	Phosphorylation	ENERMSSTPIQDNVD CCHHHCCCCCCCCCC		30108239
79	Phosphorylation	IQDNVDQTYSEELCY CCCCCCCCCCHHHHH		26552605
80	Phosphorylation	QDNVDQTYSEELCYT CCCCCCCCCHHHHHH		26552605
81	Phosphorylation	DNVDQTYSEELCYTL CCCCCCCCHHHHHHH		26552605
82	Phosphorylation	NVDQTYSEELCYTLI CCCCCCCHHHHHHHH		27642862
83	Phosphorylation	VDQTYSEELCYTLIN CCCCCCHHHHHHHHC		27642862
86	Phosphorylation	TYSEELCYTLINHRV CCCHHHHHHHHCCEE		28796482
87	Phosphorylation	YSEELCYTLINHRVL CCHHHHHHHHCCEEE		28796482
96	Ubiquitination	INHRVLCTRPSGNSA HCCEEEEECCCCCCH		25015289
96	Phosphorylation	INHRVLCTRPSGNSA HCCEEEEECCCCCCH		28796482
97	Ubiquitination	NHRVLCTRPSGNSAE CCEEEEECCCCCCHH		25015289
98	Ubiquitination	HRVLCTRPSGNSAEE CEEEEECCCCCCHHH		25015289
99	Phosphorylation	RVLCTRPSGNSAEEY EEEEECCCCCCHHHH		23401153
101	Phosphorylation	LCTRPSGNSAEEYYE EEECCCCCCHHHHHH		27642862
102	Phosphorylation	CTRPSGNSAEEYYEN EECCCCCCHHHHHHC		20164059
104	Phosphorylation	RPSGNSAEEYYENVP CCCCCCHHHHHHCCC		27642862
106	Phosphorylation	SGNSAEEYYENVPCK CCCCHHHHHHCCCCC		27155012
107	Phosphorylation	GNSAEEYYENVPCKA CCCHHHHHHCCCCCC		27155012
108	Phosphorylation	NSAEEYYENVPCKAE CCHHHHHHCCCCCCC		27642862
109	Phosphorylation	SAEEYYENVPCKAER CHHHHHHCCCCCCCC		27642862
113	Ubiquitination	YYENVPCKAERPRES HHHCCCCCCCCCHHH		25015289
114	Ubiquitination	YENVPCKAERPRESL HHCCCCCCCCCHHHH		25015289
115	Ubiquitination	ENVPCKAERPRESLG HCCCCCCCCCHHHHC		25015289
116	Ubiquitination	NVPCKAERPRESLGG CCCCCCCCCHHHHCC		25015289
120	Phosphorylation	KAERPRESLGGTETE CCCCCHHHHCCCCCE		30108239
122	Phosphorylation	ERPRESLGGTETEYS CCCHHHHCCCCCEEE		27642862
124	Phosphorylation	PRESLGGTETEYSLL CHHHHCCCCCEEECC		30108239
126	Phosphorylation	ESLGGTETEYSLLHM HHHCCCCCEEECCCC		30108239
128	Phosphorylation	LGGTETEYSLLHMPS HCCCCCEEECCCCCC		17823310
129	Phosphorylation	GGTETEYSLLHMPST CCCCCEEECCCCCCC		28111955
130	Phosphorylation	GTETEYSLLHMPSTD CCCCEEECCCCCCCC		27642862
143	Phosphorylation	TDPRHARSPEDEYEL CCCCCCCCHHHHHHH		30108239
148	Phosphorylation	ARSPEDEYELLMPHR CCCHHHHHHHHHCHH		17823310
150	Phosphorylation	SPEDEYELLMPHRIS CHHHHHHHHHCHHHH		27642862
157	Phosphorylation	LLMPHRISSHFLQQP HHHCHHHHHHHHCCC		30108239
158	Phosphorylation	LMPHRISSHFLQQPR HHCHHHHHHHHCCCC		30108239
159	Phosphorylation	MPHRISSHFLQQPRP HCHHHHHHHHCCCCC		27642862
171	Phosphorylation	PRPLMAPSETQFSHL CCCCCCCCCCCCCCC		30108239
173	Phosphorylation	PLMAPSETQFSHL-- CCCCCCCCCCCCC--		30108239
176	Phosphorylation	APSETQFSHL----- CCCCCCCCCC-----		30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
80	Y	Phosphorylation	Kinase	SYK	P43405	PSP
80	Y	Phosphorylation	Kinase	LYN	P07948	PSP
86	Y	Phosphorylation	Kinase	SYK	P43405	PSP
86	Y	Phosphorylation	Kinase	LYN	P07948	PSP
106	Y	Phosphorylation	Kinase	SYK	P43405	PSP
106	Y	Phosphorylation	Kinase	LYN	P07948	PSP
107	Y	Phosphorylation	Kinase	SYK	P43405	PSP
107	Y	Phosphorylation	Kinase	LYN	P07948	PSP
128	Y	Phosphorylation	Kinase	SYK	P43405	PSP
128	Y	Phosphorylation	Kinase	LYN	P07948	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCSAM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCSAM_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GCSAM_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.