KIF6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KIF6_HUMAN
• UniProt AC: Q6ZMV9
• Protein Name: Kinesin-like protein KIF6
• Gene Name: KIF6
• Organism: Homo sapiens (Human).
• Sequence Length: 814
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Sequence: MVKQTIQIFARVKPPVRKHQQGIYSIDEDEKLIPSLEIILPRDLADGFVNNKRESYKFKFQRIFDQDANQETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAERYSDRGIIPRTLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTILEDPDQNIHLKNLTLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEPGSATVRHAKLHLVDLAGSERVAKTGVGGHLLTEAKYINLSLHYLEQVIIALSEKHRSHIPYRNSMMTSVLRDSLGGNCMTTMIATLSLEKRNLDESISTCRFAQRVALIKNEAVLNEEINPRLVIKRLQKEIQELKDELAMVTGEQRTEALTEAELLQLEKLITSFLEDQDSDSRLEVGADMRKVHHCFHHLKKLLNDKKILENNTVSSESKDQDCQEPLKEEEYRKLRDILKQRDNEINILVNMLKKEKKKAQEALHLAGMDRREFRQSQSPPFRLGNPEEGQRMRLSSAPSQAQDFSILGKRSSLLHKKIGMREEMSLGCQEAFEIFKRDHADSVTIDDNKQILKQRFSEAKALGESINEARSKIGHLKEEITQRHIQQVALGISENMAVPLMPDQQEEKLRSQLEEEKRRYKTMFTRLKALKVEIEHLQLLMDKAKVKLQKEFEVWWAEEATNLQVNSPAVNSLDHTKPFLQTSDSQHEWSQLLSNKSSGGWEVQDQGTGRFDVCDVNARKILPSPCPSPHSQKQSSTSTPLEDSIPKRPVSSIPLTGDSQTDSDIIAFIKARQSILQKQCLGSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	Phosphorylation	AGSVLAGYNGTIFAY CCCCCCCCCCEEEEE	12.57	-
114	Phosphorylation	ITGGAERYSDRGIIP EECCCCCCCCCCCCH	13.36	-
293	Phosphorylation	ALSEKHRSHIPYRNS HHHHHHHHCCCCCHH	26.03	25072903
297	Phosphorylation	KHRSHIPYRNSMMTS HHHHCCCCCHHHHHH	23.09	25072903
300	Phosphorylation	SHIPYRNSMMTSVLR HCCCCCHHHHHHHHH	10.84	25072903
303	Phosphorylation	PYRNSMMTSVLRDSL CCCHHHHHHHHHHHC	13.67	25072903
304	Phosphorylation	YRNSMMTSVLRDSLG CCHHHHHHHHHHHCC	10.97	25072903
309	Phosphorylation	MTSVLRDSLGGNCMT HHHHHHHHCCCCHHH	23.60	-
529	Phosphorylation	MRLSSAPSQAQDFSI CCCCCCCCHHHCCCH	37.55	-
535	Phosphorylation	PSQAQDFSILGKRSS CCHHHCCCHHCCHHH	25.78	-
541	Phosphorylation	FSILGKRSSLLHKKI CCHHCCHHHHHHHHH	28.91	-
542	Phosphorylation	SILGKRSSLLHKKIG CHHCCHHHHHHHHHC	38.70	23532336
555	Phosphorylation	IGMREEMSLGCQEAF HCCHHHHCCCHHHHH	25.53	-
754	Phosphorylation	NARKILPSPCPSPHS CCCCCCCCCCCCCCC	35.37	30576142
766	Phosphorylation	PHSQKQSSTSTPLED CCCCCCCCCCCCCHH	24.71	30576142
774	Phosphorylation	TSTPLEDSIPKRPVS CCCCCHHCCCCCCCC	31.26	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KIF6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KIF6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KIF6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBP2_HUMAN	APPBP2	physical	19060904
HTR5A_HUMAN	HEATR5A	physical	26186194
SNX16_HUMAN	SNX16	physical	26186194
FEZ2_HUMAN	FEZ2	physical	26186194
SNX16_HUMAN	SNX16	physical	28514442
HTR5A_HUMAN	HEATR5A	physical	28514442
FEZ2_HUMAN	FEZ2	physical	28514442
AF10_HUMAN	MLLT10	physical	28514442
ACADS_HUMAN	ACADS	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.