LONF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LONF3_HUMAN
• UniProt AC: Q496Y0
• Protein Name: LON peptidase N-terminal domain and RING finger protein 3
• Gene Name: LONRF3
• Organism: Homo sapiens (Human).
• Sequence Length: 759
• Protein Sequence: MESVRIEQMLSLPAEVSSDNLESAERGASAAQVDMGPHPKVAAEGPAPLPTREPEQEQSPGTSTPESKVLLTQADALASRGRIREALEVYRQLSERQQLVAEQLEQLVRCLAEKVPQGEALAPAPPDEGSTASGTVAAEETGAAAAAAATEVWDGFKCRKCHGFLSDPVSLSCGHTFCKLCLERGRAADRRCALCGVKLSALMVATGRARGARRAGQQPPPPLRVNVVLSGLLGKLFPGPARASQLRHEGNRLYRERQVEAALLKYNEAVKLAPNDHLLYSNRSQIYFTLESHENALHDAEIACKLRPMGFKAHFRKAQALATLGKVEEALREFLYCVSLDGKNKRARCEAQRDNLELPHCSSQEEAAARGDGSSLMDPAKVKGDGQQHHMKDQEEEEEKWDATSPKAASSKTGKCQEKKRKHCQIESQEETGMPNKASKQDPPTDQGDKPALSLPLASFDASDLECALCMRLFYEPVTTPCGHTFCLKCLERCLDHNAKCPLCKDGLSQCLASRKYSKNVIMEELIAKFLPEELKERRKLYEEEMEELSNLNKNVPIFVCTMAYPTVPCPLHIFEPCYRLMIRRCIETGTRQFGMCLGDPVKGFAEYGCILEIRNVQFFADGRSVVDSIGKRRFRVLHQSQRDGYNTADIEYIEDQKVQGEDCAELMGLHNCVYQQASLWFHSLKLSLKNRILNHFGPMPEKDADPQMNPNGPAWCWWMLAVLPLESRAQLPFLAMRSLKDRLNGIRRVLAFISRNQN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	REPEQEQSPGTSTPE CCCCCCCCCCCCCHH	25.25	25627689
62	Phosphorylation	EQEQSPGTSTPESKV CCCCCCCCCCHHHHH	32.58	23663014
63	Phosphorylation	QEQSPGTSTPESKVL CCCCCCCCCHHHHHH	48.13	23663014
64	Phosphorylation	EQSPGTSTPESKVLL CCCCCCCCHHHHHHH	30.80	23663014
67	Phosphorylation	PGTSTPESKVLLTQA CCCCCHHHHHHHHHH	29.30	23663014
271	Ubiquitination	LKYNEAVKLAPNDHL HHHHHHHHCCCCCEE	46.08	-
317	Ubiquitination	GFKAHFRKAQALATL CHHHHHHHHHHHHHH	43.86	-
404	Phosphorylation	EEEKWDATSPKAASS HHHHCCCCCHHHHHC	42.99	24300666
405	Phosphorylation	EEKWDATSPKAASSK HHHCCCCCHHHHHCC	26.56	24300666
410	Phosphorylation	ATSPKAASSKTGKCQ CCCHHHHHCCCCCCH	36.91	-
411	Phosphorylation	TSPKAASSKTGKCQE CCHHHHHCCCCCCHH	29.52	-
413	Phosphorylation	PKAASSKTGKCQEKK HHHHHCCCCCCHHHH	43.77	-
422	Acetylation	KCQEKKRKHCQIESQ CCHHHHHHHCCCCCC	58.58	19813285
428	Phosphorylation	RKHCQIESQEETGMP HHHCCCCCCHHHCCC	44.51	-
432	Phosphorylation	QIESQEETGMPNKAS CCCCCHHHCCCCCCC	37.72	-
437	Acetylation	EETGMPNKASKQDPP HHHCCCCCCCCCCCC	48.44	19813293
440	Acetylation	GMPNKASKQDPPTDQ CCCCCCCCCCCCCCC	64.68	19813301
475	Phosphorylation	ALCMRLFYEPVTTPC HHHHHHHCCCCCCCC	24.74	22461510
480	Phosphorylation	LFYEPVTTPCGHTFC HHCCCCCCCCCCHHH	19.47	22461510
519	Ubiquitination	LASRKYSKNVIMEEL HHCCCCCCCCHHHHH	52.74	-
536	Ubiquitination	KFLPEELKERRKLYE HHCHHHHHHHHHHHH	53.07	-
589	Phosphorylation	MIRRCIETGTRQFGM HHHHHHHHCCCCCCC	24.76	-
591	Phosphorylation	RRCIETGTRQFGMCL HHHHHHCCCCCCCCC	28.81	-
625	Phosphorylation	QFFADGRSVVDSIGK EEECCCCCHHHCHHH	31.83	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LONF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LONF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LONF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NT2NL_HUMAN	NOTCH2NL	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.