| UniProt ID | SIA8E_HUMAN | |
|---|---|---|
| UniProt AC | O15466 | |
| Protein Name | Alpha-2,8-sialyltransferase 8E | |
| Gene Name | ST8SIA5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 376 | |
| Subcellular Localization |
Golgi apparatus membrane Single-pass type II membrane protein . |
|
| Protein Description | May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively.. | |
| Protein Sequence | MRYADPSANRDLLGSRTLLFIFICAFALVTLLQQILYGRNYIKRYFEFYEGPFEYNSTRCLELRHEILEVKVLSMVKQSELFDRWKSLQMCKWAMNISEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHTGTCSCC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MRYADPSANR -----CCCCCCCCCC | 17.66 | - | |
| 7 | Phosphorylation | -MRYADPSANRDLLG -CCCCCCCCCCCCCC | 38.43 | - | |
| 49 | Phosphorylation | IKRYFEFYEGPFEYN HHHHHHHHCCCCCCC | 16.87 | - | |
| 56 | N-linked_Glycosylation | YEGPFEYNSTRCLEL HCCCCCCCCCCHHHH | 29.70 | UniProtKB CARBOHYD | |
| 96 | N-linked_Glycosylation | QMCKWAMNISEANQF HHHHHHCCHHHHHHH | 27.21 | UniProtKB CARBOHYD | |
| 129 | Ubiquitination | KNTPLGTKLKYEVDT CCCCCCCEEEEEEEC | 40.98 | - | |
| 157 | Phosphorylation | FPKDMPYYRSQFKKC CCCCCHHHHHHCCCE | 9.64 | 25884760 | |
| 201 | Phosphorylation | PPISEKYTMDVGVKT CCCCCCEEECCCCCC | 20.26 | 24719451 | |
| 216 | Phosphorylation | DVVTVNPSIITERFH CEEEECHHHHHHHHH | 22.78 | 24719451 | |
| 219 | Phosphorylation | TVNPSIITERFHKLE EECHHHHHHHHHHHH | 21.31 | 24719451 | |
| 224 | Acetylation | IITERFHKLEKWRRP HHHHHHHHHHHCCCC | 56.48 | 7696481 | |
| 227 | Acetylation | ERFHKLEKWRRPFYR HHHHHHHHCCCCHHH | 57.34 | 7696491 | |
| 241 | N-linked_Glycosylation | RVLQVYENASVLLPA HHHHHHHHHHEEEEE | 21.59 | UniProtKB CARBOHYD | |
| 284 | N-linked_Glycosylation | FHPQYLVNVSRYWLS ECHHHHEEHHHHHHH | 24.37 | UniProtKB CARBOHYD |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SIA8E_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SIA8E_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SIA8E_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SELN_HUMAN | SEPN1 | physical | 26186194 | |
| SELN_HUMAN | SEPN1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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