SYT11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYT11_HUMAN
• UniProt AC: Q9BT88
• Protein Name: Synaptotagmin-11
• Gene Name: SYT11
• Organism: Homo sapiens (Human).
• Sequence Length: 431
• Subcellular Localization: Membrane ; Single-pass membrane protein . Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. In substantia nigra, observed in neuronal cell bodies and neurites. Found in the core o
• Protein Description: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis..
• Protein Sequence: MAEITNIRPSFDVSPVVAGLIGASVLVVCVSVTVFVWSCCHQQAEKKQKNPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGPGREGGRRNLLVDAAEAGLLSRDKDPRGPSSGSCIDQLPIKMDYGEELRSPITSLTPGESKTTSPSSPEEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDDQTQGSDPYIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTASGAEHWREVCESPRKPVAKWHSLSEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Ubiquitination	QQAEKKQKNPPYKFI HHHHHHHCCCCHHHH	79.06	23000965
54	Ubiquitination	KQKNPPYKFIHMLKG HHCCCCHHHHHHHHC	43.55	23000965
60	Ubiquitination	YKFIHMLKGISIYPE HHHHHHHHCCCCCHH	46.77	23000965
63	Phosphorylation	IHMLKGISIYPETLS HHHHHCCCCCHHHHC	25.41	27251275
65	Phosphorylation	MLKGISIYPETLSNK HHHCCCCCHHHHCCC	6.55	25884760
68	Phosphorylation	GISIYPETLSNKKKI CCCCCHHHHCCCCEE	30.86	25850435
70	Phosphorylation	SIYPETLSNKKKIIK CCCHHHHCCCCEEEE	54.76	22199227
72	Ubiquitination	YPETLSNKKKIIKVR CHHHHCCCCEEEEEE	52.66	32142685
73	Ubiquitination	PETLSNKKKIIKVRR HHHHCCCCEEEEEEC	54.15	30230243
128	Phosphorylation	QLPIKMDYGEELRSP CCCCCCCCCHHHCCC	23.96	25884760
134	Phosphorylation	DYGEELRSPITSLTP CCCHHHCCCCCCCCC	33.02	22199227
137	Phosphorylation	EELRSPITSLTPGES HHHCCCCCCCCCCCC	22.52	29514088
138	Phosphorylation	ELRSPITSLTPGESK HHCCCCCCCCCCCCC	30.85	29514088
140	Phosphorylation	RSPITSLTPGESKTT CCCCCCCCCCCCCCC	29.08	27732954
144	Phosphorylation	TSLTPGESKTTSPSS CCCCCCCCCCCCCCC	41.01	27732954
197	Phosphorylation	QTQGSDPYIKMTILP CCCCCCCCEEEEECC	20.40	25884760
301	Phosphorylation	ELQVSLSYQPVAQRM CEEEEEECCCCCCEE	23.33	25884760
309	Phosphorylation	QPVAQRMTVVVLKAR CCCCCEEEEEEEECC	16.61	-
331	Phosphorylation	TGLSGNPYVKVNVYY CCCCCCCCEEEEEEE	19.53	22817900
337	Phosphorylation	PYVKVNVYYGRKRIA CCEEEEEEECCCCCC	8.59	22817900
338	Phosphorylation	YVKVNVYYGRKRIAK CEEEEEEECCCCCCC	13.23	22817900
387	Phosphorylation	LVIDFDRTTKNEVVG EEEECCCCCCCHHHH	43.92	-
417	Phosphorylation	HWREVCESPRKPVAK HHHHHHHCCCCCCCC	25.52	24961811

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:12925569

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYT11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYT11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRKN_HUMAN	PARK2	physical	12925569
APBP2_HUMAN	APPBP2	physical	19060904
TTC1_HUMAN	TTC1	physical	26186194
UBE2O_HUMAN	UBE2O	physical	26186194
PDLI7_HUMAN	PDLIM7	physical	26186194
KAP1_HUMAN	PRKAR1B	physical	26186194
PDLI5_HUMAN	PDLIM5	physical	26186194
SGTA_HUMAN	SGTA	physical	21516116
TTC1_HUMAN	TTC1	physical	28514442
PDLI7_HUMAN	PDLIM7	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.