MBTD1_HUMAN - dbPTM
MBTD1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MBTD1_HUMAN
UniProt AC Q05BQ5
Protein Name MBT domain-containing protein 1
Gene Name MBTD1
Organism Homo sapiens (Human).
Sequence Length 628
Subcellular Localization Nucleus .
Protein Description Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4..
Protein Sequence MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAAVSMEGFSWGNYINSNSFIAAPVTCFKHAPMGTCWGDISENVRVEVPNTDCSLPTKVFWIAGIVKLAGYNALLRYEGFENDSGLDFWCNICGSDIHPVGWCAASGKPLVPPRTIQHKYTNWKAFLVKRLTGAKTLPPDFSQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQDGHFDTPPHLFAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPPASQSSRENQSASSKQKKKAKSQQYKGHKKMTTLQLKEELLDGEDYNFLQGASDQESNGSANFYIKQEP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42PhosphorylationIKNNGQVYTYPDGKS
EECCCEEEECCCCCC		7.83-
69AcetylationVRDAFYSKTKRFCSV
CHHHHHCCCCEEEEE		46.8423749302
81PhosphorylationCSVSCSRSYSSNSKK
EEEECCCCCCCCCCH		17.05-
84PhosphorylationSCSRSYSSNSKKASI
ECCCCCCCCCCHHHH		36.57-
88UbiquitinationSYSSNSKKASILARL
CCCCCCCHHHHHHHH		47.3829967540
90PhosphorylationSSNSKKASILARLQG
CCCCCHHHHHHHHCC		27.3224719451
109UbiquitinationKKAKVLQKQPLVAKL
HHHHHHHCCHHHHHH		50.1229967540
115AcetylationQKQPLVAKLAAYAQY
HCCHHHHHHHHHHHH		31.0523954790
131AcetylationATLQNQAKTKAAVSM
HHHHHHHHHHHCCEE		40.5725953088
268PhosphorylationKRLTGAKTLPPDFSQ
HHHHCCCCCCCCHHH		43.9218491316
302PhosphorylationDKRHLCRTRVAVVES
CCCCCCCCCEEEEHH		28.6226356563
309PhosphorylationTRVAVVESVIGGRLR
CCEEEEHHHHCCEEE		13.8726356563
322PhosphorylationLRLVYEESEDRTDDF
EEEEEECCCCCCCCC		32.6223532336
375UbiquitinationPHLFAKVKEVDQSGE
CCCEEEEEEECCCCC		51.8429967540
460PhosphorylationLTPPRGYTKLPFKWF
ECCCCCCCCCCCHHH		29.00-
465UbiquitinationGYTKLPFKWFDYLRE
CCCCCCCHHHHHHHH		45.04-
497UbiquitinationHGFRVGMKLEAVDLM
CCCCCCCEEEEECCC		36.93-
570PhosphorylationQSSRENQSASSKQKK
CCHHHCCCCCHHHHH		41.5229083192
572PhosphorylationSRENQSASSKQKKKA
HHHCCCCCHHHHHHH		43.2329083192
573PhosphorylationRENQSASSKQKKKAK
HHCCCCCHHHHHHHH		38.5329083192
591PhosphorylationYKGHKKMTTLQLKEE
HCCCCCCCHHHHHHH		32.9830622161
592PhosphorylationKGHKKMTTLQLKEEL
CCCCCCCHHHHHHHH		14.7030622161
596SumoylationKMTTLQLKEELLDGE
CCCHHHHHHHHHCCC		35.86-
605PhosphorylationELLDGEDYNFLQGAS
HHHCCCCCCCCCCCC		11.9627251275
612PhosphorylationYNFLQGASDQESNGS
CCCCCCCCCCCCCCC		46.8030301811
616PhosphorylationQGASDQESNGSANFY
CCCCCCCCCCCCCEE		40.6427251275
619PhosphorylationSDQESNGSANFYIKQ
CCCCCCCCCCEEEEE		25.0427251275
623PhosphorylationSNGSANFYIKQEP--
CCCCCCEEEEECC--		13.6627251275
625SumoylationGSANFYIKQEP----
CCCCEEEEECC----		36.91-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MBTD1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MBTD1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MBTD1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TRRAP_HUMANTRRAPphysical
27153538
EP400_HUMANEP400physical
27153538
BRD8_HUMANBRD8physical
27153538
EPC1_HUMANEPC1physical
27153538
EPC2_HUMANEPC2physical
27153538
DMAP1_HUMANDMAP1physical
27153538
KAT5_HUMANKAT5physical
27153538
ING3_HUMANING3physical
27153538
RUVB1_HUMANRUVBL1physical
27153538
RUVB2_HUMANRUVBL2physical
27153538
VPS72_HUMANVPS72physical
27153538
ACTB_HUMANACTBphysical
27153538
MRGBP_HUMANMRGBPphysical
27153538
YETS4_HUMANYEATS4physical
27153538
EAF6_HUMANMEAF6physical
27153538
ACL6A_HUMANACTL6Aphysical
27153538
MO4L1_HUMANMORF4L1physical
27153538
MO4L2_HUMANMORF4L2physical
27153538
H2AZ_HUMANH2AFZphysical
27153538
H2B1B_HUMANHIST1H2BBphysical
27153538
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MBTD1_HUMAN

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Related Literatures of Post-Translational Modification

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