CD2_HUMAN - dbPTM
CD2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CD2_HUMAN
UniProt AC P06729
Protein Name T-cell surface antigen CD2
Gene Name CD2
Organism Homo sapiens (Human).
Sequence Length 351
Subcellular Localization Cell membrane
Single-pass type I membrane protein .
Protein Description CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function..
Protein Sequence MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
77O-linked_GlycosylationQFRKEKETFKEKDTY
HHHHHHHHHHCHHHH		51.5829351928
89N-linked_GlycosylationDTYKLFKNGTLKIKH
HHHHHHHCCEEEEEE		41.157994575
99PhosphorylationLKIKHLKTDDQDIYK
EEEEECCCCCCCEEE		51.69-
106UbiquitinationTDDQDIYKVSIYDTK
CCCCCEEEEEEEECC		29.82-
125UbiquitinationLEKIFDLKIQERVSK
HHHHHHHHHHHHCCC		44.16-
141N-linked_GlycosylationKISWTCINTTLTCEV
CEEEEEECCEEEEEE		29.207994575
150N-linked_GlycosylationTLTCEVMNGTDPELN
EEEEEECCCCCCCCC		56.227994575
166UbiquitinationYQDGKHLKLSQRVIT
EECCCCEEHHHHEEE		45.90-
173PhosphorylationKLSQRVITHKWTTSL
EHHHHEEECCCCCCH		17.97-
181PhosphorylationHKWTTSLSAKFKCTA
CCCCCCHHEEEEECC		29.2227080861
194UbiquitinationTAGNKVSKESSVEPV
CCCCEECCCCCCCCC		65.68-
206UbiquitinationEPVSCPEKGLDIYLI
CCCCCCCCCCEEEEE		50.33-
258PhosphorylationTRAHRVATEERGRKP
HHHHHHHHHHCCCCC		35.21-
264UbiquitinationATEERGRKPHQIPAS
HHHHCCCCCCCCCCC		50.07-
271PhosphorylationKPHQIPASTPQNPAT
CCCCCCCCCCCCCCC		34.9527080861
272PhosphorylationPHQIPASTPQNPATS
CCCCCCCCCCCCCCC		30.8827080861
290PhosphorylationPPPPGHRSQAPSHRP
CCCCCCCCCCCCCCC		25.64-
294PhosphorylationGHRSQAPSHRPPPPG
CCCCCCCCCCCCCCC		34.83-
310UbiquitinationRVQHQPQKRPPAPSG
CCCCCCCCCCCCCCC		73.82-
324UbiquitinationGTQVHQQKGPPLPRP
CCCCCCCCCCCCCCC		67.81-
345PhosphorylationPHGAAENSLSPSSN-
CCCCCCCCCCCCCC-		23.0229978859
347PhosphorylationGAAENSLSPSSN---
CCCCCCCCCCCC---		23.6623401153
349PhosphorylationAENSLSPSSN-----
CCCCCCCCCC-----		38.8529978859
350PhosphorylationENSLSPSSN------
CCCCCCCCC------		50.3629978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CD2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CD2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CD2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SH3K1_HUMANSH3KBP1physical
12690097
CD2AP_HUMANCD2APphysical
12690097
PTPRC_HUMANPTPRCphysical
1970422
CD48_HUMANCD48physical
12356317
CD2B2_HUMANCD2BP2physical
9843987
CD5_HUMANCD5physical
10510361
LEG1_HUMANLGALS1physical
10642604
LFA3_HUMANCD58physical
11575926
ITK_HUMANITKphysical
9677430
FYN_HUMANFYNphysical
9677430
PPIP1_HUMANPSTPIP1physical
9857189
LCK_HUMANLCKphysical
8551220
CD53_HUMANCD53physical
1346273
SH3K1_HUMANSH3KBP1physical
12618476
LFA3_HUMANCD58physical
21982860
LYAR_HUMANLYARphysical
21988832
SH3K1_HUMANSH3KBP1physical
23663663
CD2AP_HUMANCD2APphysical
23663663
Drug and Disease Associations
Kegg Disease
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D05847 Siplizumab (USAN/INN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CD2_HUMAN

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Related Literatures of Post-Translational Modification

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