CD48_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD48_HUMAN
• UniProt AC: P09326
• Protein Name: CD48 antigen
• Gene Name: CD48
• Organism: Homo sapiens (Human).
• Sequence Length: 243
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor .
• Protein Description: Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation..
• Protein Sequence: MCSRGWDSCLALELLLLPLSLLVTSIQGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNYSRCYTCQVSNSVSSKNGTVCLSPPCTLARSFGVEWIASWLVVTVPTILGLLLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	N-linked_Glycosylation	MTVVSGSNVTLNISE EEEECCCEEEEECCC	34.03	UniProtKB CARBOHYD
44	N-linked_Glycosylation	SGSNVTLNISESLPE CCCEEEEECCCCCCC	26.78	UniProtKB CARBOHYD
57	Phosphorylation	PENYKQLTWFYTFDQ CCHHCEEEEEEECCC	15.84	25219547
60	Phosphorylation	YKQLTWFYTFDQKIV HCEEEEEEECCCEEE	9.69	25219547
61	Phosphorylation	KQLTWFYTFDQKIVE CEEEEEEECCCEEEE	15.97	25219547
76	Phosphorylation	WDSRKSKYFESKFKG EHHHCCHHCHHHCCC	21.48	-
104	N-linked_Glycosylation	SKVQKEDNSTYIMRV EEEEECCCCEEEEEE	37.02	19349973
124	Ubiquitination	NEQEWKIKLQVLDPV CCEEEEEEEEECCCC	29.19	-
131 (in isoform 2)	Phosphorylation	-	10.71	22210691
149	Phosphorylation	EDMDDNCYLKLSCVI EECCCCEEEEEEEEE	17.08	29759185
162	N-linked_Glycosylation	VIPGESVNYTWYGDK EECCCCEECEEECCC	37.48	UniProtKB CARBOHYD
178	N-linked_Glycosylation	PFPKELQNSVLETTL CCCHHHHCCHHHHCC	46.86	19349973
189	N-linked_Glycosylation	ETTLMPHNYSRCYTC HHCCCCCCCCCCEEE	30.51	19349973
220	GPI-anchor	PPCTLARSFGVEWIA CCCHHCHHHCHHHHH	22.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD48_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD48_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD48_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LCK_HUMAN	LCK	physical	12007789

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.";
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.;
Nat. Biotechnol. 27:378-386(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-104; ASN-178 AND ASN-189,AND MASS SPECTROMETRY.
PubMed: 19349973