dbPTM

CD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CD5_HUMAN
UniProt AC	P06127
Protein Name	T-cell surface glycoprotein CD5
Gene Name	CD5
Organism	Homo sapiens (Human).
Sequence Length	495
Subcellular Localization	Cell membrane Single-pass type I membrane protein.
Protein Description	May act as a receptor in regulating T-cell proliferation..
Protein Sequence	MPMGSLQPLATLYLLGMLVASCLGRLSWYDPDFQARLTRSNSKCQGQLEVYLKDGWHMVCSQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSSIICYGQLGSFSNCSHSRNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQLVAQSGGQHCAGVVEFYSGSLGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEAGRAQDPGEPREHQPLPIQWKIQNSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYCKKVFVTCQDPNPAGLAAGTVASIILALVLLVVLLVVCGPLAYKKLVKKFRQKKQRQWIGPTGMNQNMSFHRNHTATVRSHAENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSMQPDNSSDSDYDLHGAQRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	PDFQARLTRSNSKCQ HHHHHHHCCCCCCCC	26.88	29083192
40	Phosphorylation	FQARLTRSNSKCQGQ HHHHHCCCCCCCCEE	39.97	29083192
42	Phosphorylation	ARLTRSNSKCQGQLE HHHCCCCCCCCEEEE	35.73	29083192
51	Phosphorylation	CQGQLEVYLKDGWHM CCEEEEEEEECCEEE	9.92	29083192
79	Ubiquitination	EDPSQASKVCQRLNC CCHHHHHHHHHHCCC	50.47	-
116	N-linked_Glycosylation	GQLGSFSNCSHSRND EECCCCCCCCCCCCC	29.33	UniProtKB CARBOHYD
142	Phosphorylation	PQKTTPPTTRPPPTT CCCCCCCCCCCCCCC	36.32	22210691
150	Phosphorylation	TRPPPTTTPEPTAPP CCCCCCCCCCCCCCC	28.29	22210691
184	O-linked_Glycosylation	YSGSLGGTISYEAQD ECCCCCCEEEEECCC	12.64	OGP
186	Phosphorylation	GSLGGTISYEAQDKT CCCCCEEEEECCCCC	19.43	-
208	Phosphorylation	CNNLQCGSFLKHLPE HCCCCCCHHHHHCCC	34.72	24719451
211	Ubiquitination	LQCGSFLKHLPETEA CCCCHHHHHCCCCCC	40.88	29967540
241	N-linked_Glycosylation	PIQWKIQNSSCTSLE CCEEEEECCCCCCHH	39.09	UniProtKB CARBOHYD
273	Ubiquitination	LCSGFQPKVQSRLVG HHCCCCHHHCEEECC	41.97	-
308	Phosphorylation	CDSSSARSSLRWEEV CCCCCCHHHCCHHHH	33.18	29083192
309	Phosphorylation	DSSSARSSLRWEEVC CCCCCHHHCCHHHHH	19.19	29083192
327	Phosphorylation	QCGSVNSYRVLDAGD CCCCCCEEEEECCCC	10.27	22210691
346	Ubiquitination	GLFCPHQKLSQCHEL CCCCCCHHHHHHHHH	47.25	-
361	Ubiquitination	WERNSYCKKVFVTCQ HHHCCCCCEEEEEEC	43.68	29967540
421	Phosphorylation	QRQWIGPTGMNQNMS CCCCCCCCCCCCCCC	43.80	23684312
428	Phosphorylation	TGMNQNMSFHRNHTA CCCCCCCCEECCCCH	26.00	23401153
434	Phosphorylation	MSFHRNHTATVRSHA CCEECCCCHHHHHHC	27.80	30576142
436	Phosphorylation	FHRNHTATVRSHAEN EECCCCHHHHHHCCC	20.01	30576142
439	Phosphorylation	NHTATVRSHAENPTA CCCHHHHHHCCCCCC	23.78	19605366
445	Phosphorylation	RSHAENPTASHVDNE HHHCCCCCCCCCCCC	52.99	28796482
447	Phosphorylation	HAENPTASHVDNEYS HCCCCCCCCCCCCCC	26.90	28796482
453	Phosphorylation	ASHVDNEYSQPPRNS CCCCCCCCCCCCCCC	20.89	19605366
454	Phosphorylation	SHVDNEYSQPPRNSH CCCCCCCCCCCCCCC	29.99	28796482
460	Phosphorylation	YSQPPRNSHLSAYPA CCCCCCCCCCCHHHH	27.38	23401153
463	Phosphorylation	PPRNSHLSAYPALEG CCCCCCCCHHHHHHH	21.97	28122231
465	Phosphorylation	RNSHLSAYPALEGAL CCCCCCHHHHHHHHH	5.90	11751967
475	Phosphorylation	LEGALHRSSMQPDNS HHHHHHHHCCCCCCC	21.29	28796482
476	Phosphorylation	EGALHRSSMQPDNSS HHHHHHHCCCCCCCC	22.76	28796482
482	Phosphorylation	SSMQPDNSSDSDYDL HCCCCCCCCCCCCCC	42.79	23401153
483	Phosphorylation	SMQPDNSSDSDYDLH CCCCCCCCCCCCCCC	47.60	23401153
485	Phosphorylation	QPDNSSDSDYDLHGA CCCCCCCCCCCCCCH	39.76	28787133
487	Phosphorylation	DNSSDSDYDLHGAQR CCCCCCCCCCCCHHC	25.10	28787133

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
434	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
434	T	Phosphorylation	Kinase	PKCA	P05696	PSP
434	T	Phosphorylation	Kinase	PRKCB	P68403	GPS
434	T	Phosphorylation	Kinase	PRKCG	P05129	GPS
436	T	Phosphorylation	Kinase	PRKCG	P05129	GPS
436	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
436	T	Phosphorylation	Kinase	PKCA	P05696	PSP
436	T	Phosphorylation	Kinase	PRKCB	P68403	GPS
453	Y	Phosphorylation	Kinase	LCK	P06239	PSP
453	Y	Phosphorylation	Kinase	FYN	P06241	PSP
482	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
482	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
482	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
483	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
483	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
483	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
485	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
485	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
485	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
487	Y	Phosphorylation	Kinase	LCK	P06239	PSP
487	Y	Phosphorylation	Kinase	FYN	P06241	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	CBL	P22681	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD6_HUMAN	CD6	physical	12473675
PTN6_HUMAN	PTPN6	physical	10082557
CBL_HUMAN	CBL	physical	9603468
RASA1_HUMAN	RASA1	physical	9603468
LCK_HUMAN	LCK	physical	21757751
FYN_HUMAN	FYN	physical	21757751
CD72_HUMAN	CD72	physical	1711157

Drug and Disease Associations

Kegg Disease
H00002	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D06381	Zolimomab aritox (USAN); Orthozyme CD5 plus (TN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CD5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439; TYR-453; SER-482;SER-483 AND SER-485, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Profiling of tyrosine phosphorylation pathways in human cells usingmass spectrometry."; Salomon A.R., Ficarro S.B., Brill L.M., Brinker A., Phung Q.T.,Ericson C., Sauer K., Brock A., Horn D.M., Schultz P.G., Peters E.C.; Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439; TYR-453 ANDSER-460, AND MASS SPECTROMETRY.	12522270 [Abstract]