CD6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD6_HUMAN
• UniProt AC: P30203
• Protein Name: T-cell differentiation antigen CD6
• Gene Name: CD6
• Organism: Homo sapiens (Human).
• Sequence Length: 668
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with the TCR/CD3 complex at t
• Protein Description: Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. [PubMed: 15048703]
• Protein Sequence: MWLFFGITGLLTAALSGHPSPAPPDQLNTSSAESELWEPGERLPVRLTNGSSSCSGTVEVRLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSVAANATLAGAPALLCSGAEWRLCEVVEHACRSDGRRARVTCAENRALRLVDGGGACAGRVEMLEHGEWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRGPIHRDQVNCSGAEAYLWDCPGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADRCEGQVEVHFRGVWNTVCDSEWYPSEAKVLCQSLGCGTAVERPKGLPHSLSGRMYYSCNGEELTLSNCSWRFNNSNLCSQSLAARVLCSASRSLHNLSTPEVPASVQTVTIESSVTVKIENKESRELMLLIPSIVLGILLLGSLIFIAFILLRIKGKYALPVMVNHQHLPTTIPAGSNSYQPVPITIPKEVFMLPIQVQAPPPEDSDSGSDSDYEHYDFSAQPPVALTTFYNSQRHRVTDEEVQQSRFQMPPLEEGLEELHASHIPTANPGHCITDPPSLGPQYHPRSNSESSTSSGEDYCNSPKSKLPPWNPQVFSSERSSFLEQPPNLELAGTQPAFSAGPPADDSSSTSSGEWYQNFQPPPQPPSEEQFGCPGSPSPQPDSTDNDDYDDISAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	N-linked_Glycosylation	PAPPDQLNTSSAESE CCCCHHCCCCCCHHH	32.08	26146185
48	Phosphorylation	ERLPVRLTNGSSSCS CCCCEEEECCCCCCC	27.28	-
49	N-linked_Glycosylation	RLPVRLTNGSSSCSG CCCEEEECCCCCCCC	53.60	26146185
112	N-linked_Glycosylation	PPPPAAGNTSVAANA CCCCCCCCCCHHHCC	25.18	UniProtKB CARBOHYD
118	N-linked_Glycosylation	GNTSVAANATLAGAP CCCCHHHCCCCCCCC	24.58	UniProtKB CARBOHYD
229	N-linked_Glycosylation	PIHRDQVNCSGAEAY CCCHHHCCCCCCEEE	14.49	26146185
327	Phosphorylation	HSLSGRMYYSCNGEE CCCCCCEEEEECCCE	7.29	22817900
339	N-linked_Glycosylation	GEELTLSNCSWRFNN CCEEEEECCEEECCC	27.27	UniProtKB CARBOHYD
341	Phosphorylation	ELTLSNCSWRFNNSN EEEEECCEEECCCCC	26.07	22817900
345	N-linked_Glycosylation	SNCSWRFNNSNLCSQ ECCEEECCCCCCCCH	42.31	UniProtKB CARBOHYD
365	Phosphorylation	VLCSASRSLHNLSTP HHHHHHHHHCCCCCC	31.33	22468782
368	N-linked_Glycosylation	SASRSLHNLSTPEVP HHHHHHCCCCCCCCC	40.77	UniProtKB CARBOHYD
380	Phosphorylation	EVPASVQTVTIESSV CCCCCCEEEEEEEEE	19.91	22468782
382	Phosphorylation	PASVQTVTIESSVTV CCCCEEEEEEEEEEE	23.55	22468782
385	Phosphorylation	VQTVTIESSVTVKIE CEEEEEEEEEEEEEC	26.68	24076635
388	Phosphorylation	VTIESSVTVKIENKE EEEEEEEEEEECCHH	20.30	24076635
396	Phosphorylation	VKIENKESRELMLLI EEECCHHHHHHHHHH	32.44	29759185
405	Phosphorylation	ELMLLIPSIVLGILL HHHHHHHHHHHHHHH	20.52	-
430	Phosphorylation	LLRIKGKYALPVMVN HHHHHCCCEEEEEEE	23.26	22210691
443	Phosphorylation	VNHQHLPTTIPAGSN EECCCCCCCCCCCCC	43.66	29978859
444	Phosphorylation	NHQHLPTTIPAGSNS ECCCCCCCCCCCCCC	24.03	29978859
449	Phosphorylation	PTTIPAGSNSYQPVP CCCCCCCCCCCCCCC	25.39	29978859
451	Phosphorylation	TIPAGSNSYQPVPIT CCCCCCCCCCCCCEE	27.17	22210691
452	Phosphorylation	IPAGSNSYQPVPITI CCCCCCCCCCCCEEE	22.53	22210691
458	Phosphorylation	SYQPVPITIPKEVFM CCCCCCEEECCEEEE	25.75	29978859
480	Phosphorylation	PPPEDSDSGSDSDYE CCCCCCCCCCCCCCC	44.12	-
482	Phosphorylation	PEDSDSGSDSDYEHY CCCCCCCCCCCCCCC	37.58	-
484	Phosphorylation	DSDSGSDSDYEHYDF CCCCCCCCCCCCCCC	43.73	-
505	Phosphorylation	ALTTFYNSQRHRVTD EEEEEECCCCCCCCH	19.74	-
511	Phosphorylation	NSQRHRVTDEEVQQS CCCCCCCCHHHHHHH	37.34	-
560	Phosphorylation	GPQYHPRSNSESSTS CCCCCCCCCCCCCCC	49.51	-
562	Phosphorylation	QYHPRSNSESSTSSG CCCCCCCCCCCCCCC	39.85	-
565	Phosphorylation	PRSNSESSTSSGEDY CCCCCCCCCCCCCCC	28.40	-
567	Phosphorylation	SNSESSTSSGEDYCN CCCCCCCCCCCCCCC	37.99	-
568	Phosphorylation	NSESSTSSGEDYCNS CCCCCCCCCCCCCCC	46.41	-
572	Phosphorylation	STSSGEDYCNSPKSK CCCCCCCCCCCCHHH	6.82	25839225
629	Phosphorylation	STSSGEWYQNFQPPP CCCCCCHHHCCCCCC	6.84	22817900
662	Phosphorylation	DSTDNDDYDDISAA- CCCCCCCHHHCCCC-	20.55	1919444

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
480	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
482	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
484	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GLYG_HUMAN	GYG1	physical	21988832
NF2L1_HUMAN	NFE2L1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.