CD72_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD72_HUMAN
• UniProt AC: P21854
• Protein Name: B-cell differentiation antigen CD72
• Gene Name: CD72
• Organism: Homo sapiens (Human).
• Sequence Length: 359
• Subcellular Localization: Membrane; Single-pass type II membrane protein.
• Protein Description: Plays a role in B-cell proliferation and differentiation..
• Protein Sequence: MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQVPAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLRYLLLGLLLTCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAEAITYADLRFVK -CCCCCCHHHHHHHC	7.63	28064214
39	Phosphorylation	DDDGEITYENVQVPA CCCCCEEEECCCCCE	15.92	21394647
110	Phosphorylation	TCLLLGVTAICLGVR HHHHHHHHHHHHHHH	14.43	-
136	N-linked_Glycosylation	NRVLEVTNSSLRQQL CCHHHHCCHHHHHHH	34.47	UniProtKB CARBOHYD
153	Phosphorylation	KITQLGQSAEDLQGS HHHHHHCCHHHHHHH	31.65	28857561
167	Phosphorylation	SRRELAQSQEALQVE HHHHHHHHHHHHHHH	25.12	28857561
196	Methylation	QADRQKTKETLQSEE HHHHHHHHHHHHHHH	56.59	23644510
331	Phosphorylation	KCNKVHKTWSWWTLE CCCCCEECCEEEEEC	15.17	-
353	Phosphorylation	LPYICEMTAFRFPD- CCEEEEEECEECCC-	10.60	18452278

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
7	Y	Phosphorylation	Kinase	LYN	P07948	Uniprot
39	Y	Phosphorylation	Kinase	LYN	P07948	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD72_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD72_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN6_HUMAN	PTPN6	physical	9590210
SEM4D_HUMAN	SEMA4D	physical	11114375
PTN6_HUMAN	PTPN6	physical	11114375
BLNK_HUMAN	BLNK	physical	10820378
SIG10_HUMAN	SIGLEC10	physical	28514442
KLH15_HUMAN	KLHL15	physical	28514442
CALL3_HUMAN	CALML3	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.