LZTS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LZTS1_HUMAN
• UniProt AC: Q9Y250
• Protein Name: Leucine zipper putative tumor suppressor 1
• Gene Name: LZTS1
• Organism: Homo sapiens (Human).
• Sequence Length: 596
• Subcellular Localization: Cytoplasm. Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Associated with the plasma membrane and with microtubules. Detected in dendritic spines, esp
• Protein Description: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor..
• Protein Sequence: MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGSVSSLIS ------CCCHHHHHC	36.43	-
3	Phosphorylation	-----MGSVSSLISG -----CCCHHHHHCC	19.96	24043423
5	Phosphorylation	---MGSVSSLISGHS ---CCCHHHHHCCCC	22.56	24043423
6	Phosphorylation	--MGSVSSLISGHSF --CCCHHHHHCCCCC	27.80	24719451
9	Phosphorylation	GSVSSLISGHSFHSK CCHHHHHCCCCCCCH	35.43	24043423
12	Phosphorylation	SSLISGHSFHSKHCR HHHHCCCCCCCHHHC	28.34	24043423
15	Phosphorylation	ISGHSFHSKHCRASQ HCCCCCCCHHHCHHH	23.29	24043423
21	Phosphorylation	HSKHCRASQYKLRKS CCHHHCHHHHHHHHC	18.07	24719451
23	Phosphorylation	KHCRASQYKLRKSSH HHHCHHHHHHHHCHH	14.97	24719451
37	Phosphorylation	HLKKLNRYSDGLLRF HHHHHCCCCCCCCCC	15.27	28111955
38	Phosphorylation	LKKLNRYSDGLLRFG HHHHCCCCCCCCCCC	23.20	28857561
47	Phosphorylation	GLLRFGFSQDSGHGK CCCCCCCCCCCCCCC	33.19	27732954
50	Phosphorylation	RFGFSQDSGHGKSSS CCCCCCCCCCCCCCC	25.67	30266825
55	Phosphorylation	QDSGHGKSSSKMGKS CCCCCCCCCCCCCCC	44.42	22817900
62	Phosphorylation	SSSKMGKSEDFFYIK CCCCCCCCCCEEEEE	36.35	-
67	Phosphorylation	GKSEDFFYIKVSQKA CCCCCEEEEEECCCC	10.38	25884760
71	Phosphorylation	DFFYIKVSQKARGSH CEEEEEECCCCCCCC	22.44	26670566
82	Phosphorylation	RGSHHPDYTALSSGD CCCCCCCCCCCCCCC	9.81	19690332
87	Phosphorylation	PDYTALSSGDLGGQA CCCCCCCCCCCCCCC	36.86	19690332
101	Phosphorylation	AGVDFDPSTPPKLMP CCCCCCCCCCCCCCC	56.22	26074081
102	Phosphorylation	GVDFDPSTPPKLMPF CCCCCCCCCCCCCCC	49.34	26074081
117	Phosphorylation	SNQLEMGSEKGAVRP CCCCCCCCCCCCCCC	34.52	26074081
134	Phosphorylation	FKPVLPRSGAILHSS CCCCCCCCCEEECCC	30.54	29396449
140	Phosphorylation	RSGAILHSSPESASH CCCEEECCCCCHHHC	44.11	29255136
141	Phosphorylation	SGAILHSSPESASHQ CCEEECCCCCHHHCC	23.18	28464451
144	Phosphorylation	ILHSSPESASHQLHP EECCCCCHHHCCCCC	38.16	29255136
146	Phosphorylation	HSSPESASHQLHPAP CCCCCHHHCCCCCCC	22.50	29255136
163	Ubiquitination	KPKEQELKPGLCSGA CCCCCCCCCCCCCCC	35.97	29967540
168	Phosphorylation	ELKPGLCSGALSDSG CCCCCCCCCCCCCCC	31.95	27732954
172	Phosphorylation	GLCSGALSDSGRNSM CCCCCCCCCCCCCCC	29.24	30266825
174	Phosphorylation	CSGALSDSGRNSMSS CCCCCCCCCCCCCCC	35.95	30266825
178	Phosphorylation	LSDSGRNSMSSLPTH CCCCCCCCCCCCCCC	20.76	26074081
180	Phosphorylation	DSGRNSMSSLPTHST CCCCCCCCCCCCCCC	28.66	26074081
181	Phosphorylation	SGRNSMSSLPTHSTS CCCCCCCCCCCCCCC	29.71	26074081
184	Phosphorylation	NSMSSLPTHSTSSSY CCCCCCCCCCCCCCC	33.48	27732954
186	Phosphorylation	MSSLPTHSTSSSYQL CCCCCCCCCCCCCCC	32.25	27732954
187	Phosphorylation	SSLPTHSTSSSYQLD CCCCCCCCCCCCCCC	25.64	27732954
188	Phosphorylation	SLPTHSTSSSYQLDP CCCCCCCCCCCCCCC	21.94	27732954
189	Phosphorylation	LPTHSTSSSYQLDPL CCCCCCCCCCCCCCC	32.90	27732954
190	Phosphorylation	PTHSTSSSYQLDPLV CCCCCCCCCCCCCCC	19.37	27732954
191	Phosphorylation	THSTSSSYQLDPLVT CCCCCCCCCCCCCCC	18.29	26074081
198	Phosphorylation	YQLDPLVTPVGPTSR CCCCCCCCCCCCCCC	21.68	26074081
203	Phosphorylation	LVTPVGPTSRFGGSA CCCCCCCCCCCCCCC	26.97	26074081
204	Phosphorylation	VTPVGPTSRFGGSAH CCCCCCCCCCCCCCC	28.84	26074081
209	Phosphorylation	PTSRFGGSAHNITQG CCCCCCCCCCCCCCC	27.08	29255136
214	Phosphorylation	GGSAHNITQGIVLQD CCCCCCCCCCEEEEC	26.51	19690332
222	Phosphorylation	QGIVLQDSNMMSLKA CCEEEECCCCCCEEE	17.42	26714015
226	Phosphorylation	LQDSNMMSLKALSFS EECCCCCCEEEEEEC	18.89	27251275
231	Phosphorylation	MMSLKALSFSDGGSK CCCEEEEEECCCCCC	27.80	30266825
233	Phosphorylation	SLKALSFSDGGSKLG CEEEEEECCCCCCCC	31.78	29255136
237	Phosphorylation	LSFSDGGSKLGHSNK EEECCCCCCCCCCCC	30.18	30266825
238	Ubiquitination	SFSDGGSKLGHSNKA EECCCCCCCCCCCCC	62.86	29967540
250	Phosphorylation	NKADKGPSCVRSPIS CCCCCCCCCCCCCCC	33.63	28122231
254	Phosphorylation	KGPSCVRSPISTDEC CCCCCCCCCCCCCCC	13.24	29255136
257	Phosphorylation	SCVRSPISTDECSIQ CCCCCCCCCCCCCHH	32.94	29255136
258	Phosphorylation	CVRSPISTDECSIQE CCCCCCCCCCCCHHH	36.22	29255136
262	Phosphorylation	PISTDECSIQELEQK CCCCCCCCHHHHHHH	25.84	27732954
269	Ubiquitination	SIQELEQKLLEREGA CHHHHHHHHHHHHHH	45.74	29967540
279	Ubiquitination	EREGALQKLQRSFEE HHHHHHHHHHHHHHH	47.65	29967540
283	Phosphorylation	ALQKLQRSFEEKELA HHHHHHHHHHHHHHH	24.85	28464451
287	Ubiquitination	LQRSFEEKELASSLA HHHHHHHHHHHHHHH	51.32	29967540
295	Phosphorylation	ELASSLAYEERPRRC HHHHHHHHHHCCCCC	24.50	28796482
351	Phosphorylation	QLRQELESLMKEQDL HHHHHHHHHHHHHHH	46.52	22468782
362	Ubiquitination	EQDLLETKLRSYERE HHHHHHHHHHHHHHH	32.31	29967540
365	Phosphorylation	LLETKLRSYEREKTS HHHHHHHHHHHHHCC	41.61	22468782
392	Phosphorylation	CQKSGEISLLKQQLK HHHHHHHHHHHHHHH	24.28	24719451
433	Phosphorylation	LEGLELRTQDLEGAL CCCEECCHHCHHHHH	38.77	-
457 (in isoform 5)	Phosphorylation	-	47.17	27174698
458 (in isoform 5)	Phosphorylation	-	63.31	27174698
458	Ubiquitination	ENELQRKKNEAELLR HHHHHHHHHHHHHHH	63.31	29967540
462 (in isoform 5)	Phosphorylation	-	42.00	27174698
467	Ubiquitination	EAELLREKVNLLEQE HHHHHHHHHHHHHHH	29.95	29967540
549	Phosphorylation	YQKQLQQSYVAMYQR HHHHHHHHHHHHHHH	14.49	26699800
550	Phosphorylation	QKQLQQSYVAMYQRN HHHHHHHHHHHHHHH	6.46	26699800
554	Phosphorylation	QQSYVAMYQRNQRLE HHHHHHHHHHHHHHH	8.45	26699800
572	Phosphorylation	QQLARGDSAGEPLEV HHHHCCCCCCCCCEE	40.78	29507054

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LZTS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LZTS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LZTS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1G_HUMAN	EEF1G	physical	11504921
CDK1_HUMAN	CDK1	physical	11504921

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 133239: Esophageal cancer (ESCR)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.