NUD15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUD15_HUMAN
• UniProt AC: Q9NV35
• Protein Name: Nucleotide triphosphate diphosphatase NUDT15 {ECO:0000305}
• Gene Name: NUDT15 {ECO:0000312|HGNC:HGNC:23063}
• Organism: Homo sapiens (Human).
• Sequence Length: 164
• Protein Description: May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. [PubMed: 26238318 Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives]
• Protein Sequence: MTASAQPRGRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECAQRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPKNVEPEKNESWEWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVGYKGNHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTASAQPRG ------CCCCCCCCC	29.35	22210691
4	Phosphorylation	----MTASAQPRGRR ----CCCCCCCCCCC	20.47	22210691
8	Methylation	MTASAQPRGRRPGVG CCCCCCCCCCCCCCC	38.89	115485733
22	Phosphorylation	GVGVVVTSCKHPRCV CEEEEEECCCCCCEE	15.01	-
42	Phosphorylation	KGSVGAGSFQLPGGH CCCCCCCCEECCCCC	14.86	24275569
90	Phosphorylation	SFIEKENYHYVTILM HHHHHCCEEEEEEEE	8.81	-
92	Phosphorylation	IEKENYHYVTILMKG HHHCCEEEEEEEEEC	6.74	23898821
94	Phosphorylation	KENYHYVTILMKGEV HCCEEEEEEEEECEE	10.96	-
110	Ubiquitination	VTHDSEPKNVEPEKN CCCCCCCCCCCCCCC	70.36	29967540
150	Ubiquitination	EQGYDPFKEDLNHLV HCCCCCHHHHHHHHH	56.56	29967540
160	Ubiquitination	LNHLVGYKGNHL--- HHHHHCCCCCCC---	47.51	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUD15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUD15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUD15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PORED_HUMAN	SRD5A3	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.