PKHN1_HUMAN - dbPTM
PKHN1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PKHN1_HUMAN
UniProt AC Q494U1
Protein Name Pleckstrin homology domain-containing family N member 1
Gene Name PLEKHN1
Organism Homo sapiens (Human).
Sequence Length 663
Subcellular Localization Cell membrane
Lipid-anchor .
Protein Description
Protein Sequence MGNSHCVPQAPRRLRASFSRKPSLKGNREDSARMSAGLPGPEAARSGDAAANKLFHYIPGTDILDLENQRENLEQPFLSVFKKGRRRVPVRNLGKVVHYAKVQLRFQHSQDVSDCYLELFPAHLYFQAHGSEGLTFQGLLPLTELSVCPLEGSREHAFQITGVWDASRAPRGTPDPGLGEGPALWLRSTCVYVCALSALPAGPLPAPLLVLCPSRAELDRWLYHLEKQTALLGGPRRCHSAPPQGSCGDELPWTLQRRLTRLRTASGHEPGGSAVCASRVKLQHLPAQEQWDRLLVLYPTSLAIFSEELDGLCFKGELPLRAVHINLEEKEKQIRSFLIEGPLINTIRVVCASYEDYGHWLLCLRAVTHREGAPPLPGAESFPGSQVMGSGRGSLSSGGQTSWDSGCLAPPSTRTSHSLPESSVPSTVGCSSQHTPDQANSDRASIGRRRTELRRSGSSRSPGSKARAEGRGPVTPLHLDLTQLHRLSLESSPDAPDHTSETSHSPLYADPYTPPATSHRRVTDVRGLEEFLSAMQSARGPTPSSPLPSVPVSVPASDPRSCSSGPAGPYLLSKKGALQSRAAQRHRGSAKDGGPQPPDAPQLVSSAREGSPEPWLPLTDGRSPRRSRDPGYDHLWDETLSSSHQKCPQLGGPEASGGLVQWI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGNSHCVPQ
------CCCCCCCCC		44.3325043870
17PhosphorylationAPRRLRASFSRKPSL
CCHHHHHHHCCCCCC		19.8130266825
19PhosphorylationRRLRASFSRKPSLKG
HHHHHHHCCCCCCCC		36.5830266825
23PhosphorylationASFSRKPSLKGNRED
HHHCCCCCCCCCHHH		45.8329083192
25MethylationFSRKPSLKGNREDSA
HCCCCCCCCCHHHHH		59.48116252839
35PhosphorylationREDSARMSAGLPGPE
HHHHHHHHCCCCCHH		17.4029255136
57PhosphorylationAANKLFHYIPGTDIL
HHHHHHHHCCCCCCC		11.0727642862
79PhosphorylationNLEQPFLSVFKKGRR
CCCCCHHHHHHCCCC		26.3625850435
200 (in isoform 2)Phosphorylation-34.58-
240PhosphorylationGGPRRCHSAPPQGSC
CCCCCCCCCCCCCCC		46.20-
254PhosphorylationCGDELPWTLQRRLTR
CCCCCCHHHHHHHHH		15.8627050516
264PhosphorylationRRLTRLRTASGHEPG
HHHHHHHHCCCCCCC		29.7528985074
266PhosphorylationLTRLRTASGHEPGGS
HHHHHHCCCCCCCCC		39.8228857561
273PhosphorylationSGHEPGGSAVCASRV
CCCCCCCCCEECCCC		24.3628961369
302PhosphorylationLVLYPTSLAIFSEEL
HHHHHCCHHHHHHHC		4.6918191643
354PhosphorylationIRVVCASYEDYGHWL
EEEEEECCHHHHHHH		8.3618191643
383PhosphorylationLPGAESFPGSQVMGS
CCCCCCCCCCCCCCC		51.29-
409PhosphorylationSWDSGCLAPPSTRTS
CCCCCCCCCCCCCCC		20.3124719451
422PhosphorylationTSHSLPESSVPSTVG
CCCCCCCCCCCCCCC		34.3928348404
423PhosphorylationSHSLPESSVPSTVGC
CCCCCCCCCCCCCCC		36.0628348404
426PhosphorylationLPESSVPSTVGCSSQ
CCCCCCCCCCCCCCC		33.3028348404
427PhosphorylationPESSVPSTVGCSSQH
CCCCCCCCCCCCCCC		18.1728348404
431PhosphorylationVPSTVGCSSQHTPDQ
CCCCCCCCCCCCCCC		27.4028348404
432PhosphorylationPSTVGCSSQHTPDQA
CCCCCCCCCCCCCCC		30.0228348404
435PhosphorylationVGCSSQHTPDQANSD
CCCCCCCCCCCCCCC		22.4121712546
441PhosphorylationHTPDQANSDRASIGR
CCCCCCCCCCHHHHH		31.3323898821
451PhosphorylationASIGRRRTELRRSGS
HHHHHHHHHHHHCCC		37.2424702127
456PhosphorylationRRTELRRSGSSRSPG
HHHHHHHCCCCCCCC		36.2723403867
458PhosphorylationTELRRSGSSRSPGSK
HHHHHCCCCCCCCHH		24.6723403867
459PhosphorylationELRRSGSSRSPGSKA
HHHHCCCCCCCCHHH		40.0623403867
461PhosphorylationRRSGSSRSPGSKARA
HHCCCCCCCCHHHHH		35.2424719451
464PhosphorylationGSSRSPGSKARAEGR
CCCCCCCHHHHHCCC		26.9023532336
471PhosphorylationSKARAEGRGPVTPLH
HHHHHCCCCCCCCCC		37.4324719451
492PhosphorylationHRLSLESSPDAPDHT
HHCCCCCCCCCCCCC		19.8824719451
499PhosphorylationSPDAPDHTSETSHSP
CCCCCCCCCCCCCCC		35.3227642862
500PhosphorylationPDAPDHTSETSHSPL
CCCCCCCCCCCCCCC		35.1427642862
502PhosphorylationAPDHTSETSHSPLYA
CCCCCCCCCCCCCCC		31.3527642862
503PhosphorylationPDHTSETSHSPLYAD
CCCCCCCCCCCCCCC		20.2327642862
505PhosphorylationHTSETSHSPLYADPY
CCCCCCCCCCCCCCC		19.1727273156
508PhosphorylationETSHSPLYADPYTPP
CCCCCCCCCCCCCCC		16.6118191643
512PhosphorylationSPLYADPYTPPATSH
CCCCCCCCCCCCCCC		32.2127642862
513PhosphorylationPLYADPYTPPATSHR
CCCCCCCCCCCCCCC		28.3427273156
518PhosphorylationPYTPPATSHRRVTDV
CCCCCCCCCCCCCCC		19.66-
523PhosphorylationATSHRRVTDVRGLEE
CCCCCCCCCCCCHHH		27.2824719451
542PhosphorylationMQSARGPTPSSPLPS
HHHCCCCCCCCCCCC		38.3325850435
544PhosphorylationSARGPTPSSPLPSVP
HCCCCCCCCCCCCCC		47.2525850435
545PhosphorylationARGPTPSSPLPSVPV
CCCCCCCCCCCCCCE		31.4928348404
549PhosphorylationTPSSPLPSVPVSVPA
CCCCCCCCCCEECCC		46.8925850435
557PhosphorylationVPVSVPASDPRSCSS
CCEECCCCCCCCCCC		41.9222210691
559PhosphorylationVSVPASDPRSCSSGP
EECCCCCCCCCCCCC		27.8224719451
563PhosphorylationASDPRSCSSGPAGPY
CCCCCCCCCCCCCHH		39.3122210691
564PhosphorylationSDPRSCSSGPAGPYL
CCCCCCCCCCCCHHH		53.7928555341
570PhosphorylationSSGPAGPYLLSKKGA
CCCCCCHHHHCCHHH		21.2527273156
571PhosphorylationSGPAGPYLLSKKGAL
CCCCCHHHHCCHHHH		4.98-
573PhosphorylationPAGPYLLSKKGALQS
CCCHHHHCCHHHHHH		29.7128152594
580PhosphorylationSKKGALQSRAAQRHR
CCHHHHHHHHHHHHC		25.4128188228
611PhosphorylationVSSAREGSPEPWLPL
HHHHCCCCCCCCCCC		22.7228355574
619PhosphorylationPEPWLPLTDGRSPRR
CCCCCCCCCCCCCCC		34.1723927012
623PhosphorylationLPLTDGRSPRRSRDP
CCCCCCCCCCCCCCC		28.4327422710
627PhosphorylationDGRSPRRSRDPGYDH
CCCCCCCCCCCCCCH		42.1727259358
632PhosphorylationRRSRDPGYDHLWDET
CCCCCCCCCHHHHHH		12.9421609022
643PhosphorylationWDETLSSSHQKCPQL
HHHHHCCCCCCCCCC		26.9328555341
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PKHN1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PKHN1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PKHN1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LZTS2_HUMANLZTS2physical
25416956
SPERT_HUMANSPERTphysical
25416956
RFX6_HUMANRFX6physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PKHN1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, AND MASSSPECTROMETRY.
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-570, AND MASSSPECTROMETRY.

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