| UniProt ID | APCL_HUMAN | |
|---|---|---|
| UniProt AC | O95996 | |
| Protein Name | Adenomatous polyposis coli protein 2 | |
| Gene Name | APC2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 2303 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . Golgi apparatus . Cytoplasm . Cytoplasm, perinuclear region . Associated with actin filaments (PubMed:11691822, PubMed:25753423). Associated with microtubule network (PubMed:10644998, PubMed:11691822, PubMed:25753423). | |
| Protein Description | Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. [PubMed: 25753423 May also function in Wnt signaling by promoting the rapid degradation of CTNNB1] | |
| Protein Sequence | MASSVAPYEQLVRQVEALKAENSHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVLVSSGQTEVLEQLKALQMDITSLYNLKFQPPTLGPEPAARTPEGSPVHGSGPSKDSFGELSRATIRLLEELDRERCFLLNEIEKEEKEKLWYYSQLQGLSKRLDELPHVETQFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQALLAVKSVPVDEDPETEVPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAAAGGRAGAPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDGGPEGGGAGSAPIPIEPQICQATCAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLASDSEELHQVVSSILRNLSWRADINSKKVLREAGSVTALVQCVLRATKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYKCQSNSLAIIESGGGILRNVSSLVATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSARDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKHQAAATAVSPGSCVPSLYVRKQRALEAELDARHLAQALEHLEKQGPPAAEAATKKPLPPLRHLDGLAQDYASDSGCFDDDDAPSSLAAAAATGEPASPAALSLFLGSPFLQGQALARTPPTRRGGKEAEKDTSGEAAVAAKAKAKLALAVARIDQLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGPEGGRREAGSRAHPLLRLKAAHASLSNDSLNSGSASDGYCPREHMLPCPLAALASRREDPRCGQPRPSRLDLDLPGCQAEPPAREATSADARVRTIKLSPTYQHVPLLEGASRAGAEPLAGPGISPGARKQAWLPADHLSKVPEKLAAAPLSVASKALQKLAAQEGPLSLSRCSSLSSLSSAGRPGPSEGGDLDDSDSSLEGLEEAGPSEAELDSTWRAPGATSLPVAIPAPRRNRGRGLGVEDATPSSSSENYVQETPLVLSRCSSVSSLGSFESPSIASSIPSEPCSGQGSGTISPSELPDSPGQTMPPSRSKTPPLAPAPQGPPEATQFSLQWESYVKRFLDIADCRERCRLPSELDAGSVRFTVEKPDENFSCASSLSALALHEHYVQQDVELRLLPSACPERGGGAGGAGLHFAGHRRREEGPAPTGSRPRGAADQELELLRECLGAAVPARLRKVASALVPGRRALPVPVYMLVPAPAPAQEDDSCTDSAEGTPVNFSSAASLSDETLQGPPRDQPGGPAGRQRPTGRPTSARQAMGHRHKAGGAGRSAEQSRGAGKNRAGLELPLGRPPSAPADKDGSKPGRTRGDGALQSLCLTTPTEEAVYCFYGNDSDEEPPAAAPTPTHRRTSAIPRAFTRERPQGRKEAPAPSKAAPAAPPPARTQPSLIADETPPCYSLSSSASSLSEPEPSEPPAVHPRGREPAVTKDPGPGGGRDSSPSPRAAEELLQRCISSALPRRRPPVSGLRRRKPRATRLDERPAEGSRERGEEAAGSDRASDLDSVEWRAIQEGANSIVTWLHQAAAATREASSESDSILSFVSGLSVGSTLQPPKHRKGRQAEGEMGSARRPEKRGAASVKTSGSPRSPAGPEKPRGTQKTTPGVPAVLRGRTVIYVPSPAPRAQPKGTPGPRATPRKVAPPCLAQPAAPAKVPSPGQQRSRSLHRPAKTSELATLSQPPRSATPPARLAKTPSSSSSQTSPASQPLPRKRPPVTQAAGALPGPGASPVPKTPARTLLAKQHKTQRSPVRIPFMQRPARRGPPPLARAVPEPGPRGRAGTEAGPGARGGRLGLVRVASALSSGSESSDRSGFRRQLTFIKESPGLRRRRSELSSAESAASAPQGASPRRGRPALPAVFLCSSRCEELRAAPRQGPAPARQRPPAARPSPGERPARRTTSESPSRLPVRAPAARPETVKRYASLPHISVARRPDGAVPAAPASADAARRSSDGEPRPLPRVAAPGTTWRRIRDEDVPHILRSTLPATALPLRGSTPEDAPAGPPPRKTSDAVVQTEEVAAPKTNSSTSPSLETREPPGAPAGGQLSLLGSDVDGPSLAKAPISAPFVHEGLGVAVGGFPASRHGSPSRSARVPPFNYVPSPMVVAATTDSAAEKAPATASATLLE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASSVAPYEQ -----CCCCCCCHHH | 24043423 | ||
| 4 | O-linked_Glycosylation | ----MASSVAPYEQL ----CCCCCCCHHHH | 31492838 | ||
| 4 | Phosphorylation | ----MASSVAPYEQL ----CCCCCCCHHHH | 24043423 | ||
| 8 | Phosphorylation | MASSVAPYEQLVRQV CCCCCCCHHHHHHHH | 24043423 | ||
| 84 | Phosphorylation | KALQMDITSLYNLKF HHHCCCHHHHHCCCC | 22210691 | ||
| 85 | Phosphorylation | ALQMDITSLYNLKFQ HHCCCHHHHHCCCCC | 22210691 | ||
| 87 | Phosphorylation | QMDITSLYNLKFQPP CCCHHHHHCCCCCCC | 23403867 | ||
| 104 | Phosphorylation | GPEPAARTPEGSPVH CCCCCCCCCCCCCCC | 25921289 | ||
| 108 | Phosphorylation | AARTPEGSPVHGSGP CCCCCCCCCCCCCCC | 25921289 | ||
| 113 | Phosphorylation | EGSPVHGSGPSKDSF CCCCCCCCCCCCCCH | - | ||
| 116 | Phosphorylation | PVHGSGPSKDSFGEL CCCCCCCCCCCHHHH | - | ||
| 196 | Phosphorylation | FEAQHIRSLMEERFG HHHHHHHHHHHHHHC | 29116813 | ||
| 204 | Phosphorylation | LMEERFGTSDEMVQR HHHHHHCCCHHHHHH | 22210691 | ||
| 205 | Phosphorylation | MEERFGTSDEMVQRA HHHHHCCCHHHHHHH | 22210691 | ||
| 217 | Phosphorylation | QRAQIRASRLEQIDK HHHHHHHHHHHHHHH | 22210691 | ||
| 304 | Phosphorylation | AMSSSPESCVAMRRS HHCCCHHHHHHHHHH | - | ||
| 427 | Phosphorylation | KLSFDEEYRRAMNEL HCCCCHHHHHHHHHH | 28152594 | ||
| 448 | Phosphorylation | AELLQVDYEMHKMTR HHHHHHHHHHHHCCC | 28787133 | ||
| 454 | Phosphorylation | DYEMHKMTRDPLNLA HHHHHHCCCCHHHHH | 22210691 | ||
| 471 | Phosphorylation | RYAGMTLTNLTFGDV HHCCCEEECCCHHHH | 22210691 | ||
| 510 | Phosphorylation | EELHQVVSSILRNLS HHHHHHHHHHHHHCC | - | ||
| 511 | Phosphorylation | ELHQVVSSILRNLSW HHHHHHHHHHHHCCH | 24719451 | ||
| 517 | Phosphorylation | SSILRNLSWRADINS HHHHHHCCHHCCCCC | 24719451 | ||
| 524 | Phosphorylation | SWRADINSKKVLREA CHHCCCCCHHHHHHH | 24260401 | ||
| 609 | Phosphorylation | GILRNVSSLVATRED CHHHCHHHHHHCHHH | 23612710 | ||
| 613 | Phosphorylation | NVSSLVATREDYRQV CHHHHHHCHHHHHHH | 23612710 | ||
| 678 | Phosphorylation | MLRNLVHSKHKMIAM HHHHHHHCHHHHHHH | 21406692 | ||
| 687 | Phosphorylation | HKMIAMGSAAALRNL HHHHHHHHHHHHHHH | 17322306 | ||
| 717 | Phosphorylation | SPGSCVPSLYVRKQR CCCCCCCHHHHHHHH | 24719451 | ||
| 834 | Phosphorylation | KEAEKDTSGEAAVAA CCCCCCCCHHHHHHH | 26437602 | ||
| 873 | Phosphorylation | TSSDDSFSLSSGDPG CCCCCCCCCCCCCCC | - | ||
| 875 | Phosphorylation | SDDSFSLSSGDPGQE CCCCCCCCCCCCCCC | - | ||
| 876 | Phosphorylation | DDSFSLSSGDPGQEA CCCCCCCCCCCCCCC | - | ||
| 992 | Phosphorylation | SADARVRTIKLSPTY CCCCEEEEEEECCCC | 27251275 | ||
| 996 | Phosphorylation | RVRTIKLSPTYQHVP EEEEEEECCCCCCCC | 27251275 | ||
| 998 | Phosphorylation | RTIKLSPTYQHVPLL EEEEECCCCCCCCCC | 27251275 | ||
| 999 | Phosphorylation | TIKLSPTYQHVPLLE EEEECCCCCCCCCCC | - | ||
| 1022 | Phosphorylation | PLAGPGISPGARKQA CCCCCCCCCCHHHHC | 27732954 | ||
| 1052 | Phosphorylation | AAPLSVASKALQKLA HCCHHHHHHHHHHHH | - | ||
| 1066 | Phosphorylation | AAQEGPLSLSRCSSL HHHHCCCCHHHHHCH | 24719451 | ||
| 1068 | Phosphorylation | QEGPLSLSRCSSLSS HHCCCCHHHHHCHHH | 27732954 | ||
| 1148 | Phosphorylation | DATPSSSSENYVQET CCCCCCCCCCCCCCC | - | ||
| 1155 | Phosphorylation | SENYVQETPLVLSRC CCCCCCCCCCHHCCC | 27732954 | ||
| 1160 | Phosphorylation | QETPLVLSRCSSVSS CCCCCHHCCCCCCCC | 27732954 | ||
| 1164 | Phosphorylation | LVLSRCSSVSSLGSF CHHCCCCCCCCCCCC | - | ||
| 1167 | Phosphorylation | SRCSSVSSLGSFESP CCCCCCCCCCCCCCC | - | ||
| 1211 | Phosphorylation | QTMPPSRSKTPPLAP CCCCCCCCCCCCCCC | 24076635 | ||
| 1213 | Phosphorylation | MPPSRSKTPPLAPAP CCCCCCCCCCCCCCC | 24076635 | ||
| 1427 | Methylation | GGPAGRQRPTGRPTS CCCCCCCCCCCCCCH | - | ||
| 1431 | Methylation | GRQRPTGRPTSARQA CCCCCCCCCCHHHHH | - | ||
| 1531 | Phosphorylation | TPTHRRTSAIPRAFT CCCCCCCCCCCCCCC | 24719451 | ||
| 1585 | Phosphorylation | SLSSSASSLSEPEPS ECCCCCCCCCCCCCC | - | ||
| 1587 | Phosphorylation | SSSASSLSEPEPSEP CCCCCCCCCCCCCCC | - | ||
| 1618 | Phosphorylation | GPGGGRDSSPSPRAA CCCCCCCCCCCHHHH | 22210691 | ||
| 1621 | Phosphorylation | GGRDSSPSPRAAEEL CCCCCCCCHHHHHHH | 17081983 | ||
| 1635 | Phosphorylation | LLQRCISSALPRRRP HHHHHHHHCCCCCCC | 24719451 | ||
| 1675 | Phosphorylation | RGEEAAGSDRASDLD HHHHHCCCCCCHHHH | 19413330 | ||
| 1761 | Phosphorylation | RGAASVKTSGSPRSP CCCCCCCCCCCCCCC | 24173317 | ||
| 1762 | Phosphorylation | GAASVKTSGSPRSPA CCCCCCCCCCCCCCC | 24173317 | ||
| 1764 | Phosphorylation | ASVKTSGSPRSPAGP CCCCCCCCCCCCCCC | 29759185 | ||
| 1767 | Phosphorylation | KTSGSPRSPAGPEKP CCCCCCCCCCCCCCC | 24173317 | ||
| 1834 | Phosphorylation | AAPAKVPSPGQQRSR CCCCCCCCCCCCCCC | 27174698 | ||
| 1840 | Phosphorylation | PSPGQQRSRSLHRPA CCCCCCCCCCCCCCC | 27174698 | ||
| 1842 | Phosphorylation | PGQQRSRSLHRPAKT CCCCCCCCCCCCCCC | 27174698 | ||
| 1861 | Phosphorylation | TLSQPPRSATPPARL HCCCCCCCCCCCHHH | - | ||
| 1863 | Phosphorylation | SQPPRSATPPARLAK CCCCCCCCCCHHHCC | - | ||
| 1871 | Phosphorylation | PPARLAKTPSSSSSQ CCHHHCCCCCCCCCC | 27732954 | ||
| 1873 | Phosphorylation | ARLAKTPSSSSSQTS HHHCCCCCCCCCCCC | 27732954 | ||
| 1874 | Phosphorylation | RLAKTPSSSSSQTSP HHCCCCCCCCCCCCC | 27732954 | ||
| 1875 | Phosphorylation | LAKTPSSSSSQTSPA HCCCCCCCCCCCCCC | 27732954 | ||
| 1876 | Phosphorylation | AKTPSSSSSQTSPAS CCCCCCCCCCCCCCC | 27732954 | ||
| 1877 | Phosphorylation | KTPSSSSSQTSPASQ CCCCCCCCCCCCCCC | 27732954 | ||
| 1879 | Phosphorylation | PSSSSSQTSPASQPL CCCCCCCCCCCCCCC | 27732954 | ||
| 1880 | Phosphorylation | SSSSSQTSPASQPLP CCCCCCCCCCCCCCC | 27732954 | ||
| 1883 | Phosphorylation | SSQTSPASQPLPRKR CCCCCCCCCCCCCCC | 27732954 | ||
| 1977 | Phosphorylation | LGLVRVASALSSGSE HHHHHHHHHHHCCCC | 29116813 | ||
| 2009 | Phosphorylation | PGLRRRRSELSSAES CCHHHHHHHHHHHHH | 27732954 | ||
| 2012 | Phosphorylation | RRRRSELSSAESAAS HHHHHHHHHHHHHHH | 27732954 | ||
| 2013 | Phosphorylation | RRRSELSSAESAASA HHHHHHHHHHHHHHC | 27732954 | ||
| 2016 | Phosphorylation | SELSSAESAASAPQG HHHHHHHHHHHCCCC | 27732954 | ||
| 2019 | Phosphorylation | SSAESAASAPQGASP HHHHHHHHCCCCCCC | 27732954 | ||
| 2025 | Phosphorylation | ASAPQGASPRRGRPA HHCCCCCCCCCCCCC | 27732954 | ||
| 2040 | Phosphorylation | LPAVFLCSSRCEELR CCHHHHCCHHHHHHH | 22210691 | ||
| 2041 | Phosphorylation | PAVFLCSSRCEELRA CHHHHCCHHHHHHHC | 21406692 | ||
| 2067 | Phosphorylation | RPPAARPSPGERPAR CCCCCCCCCCCCCCC | 25002506 | ||
| 2101 | Phosphorylation | ETVKRYASLPHISVA HHHHHHHCCCEEEEE | 24850871 | ||
| 2128 | Phosphorylation | SADAARRSSDGEPRP CHHHHHHCCCCCCCC | 21406692 | ||
| 2129 | Phosphorylation | ADAARRSSDGEPRPL HHHHHHCCCCCCCCC | 21406692 | ||
| 2172 | Phosphorylation | TALPLRGSTPEDAPA CCCCCCCCCCCCCCC | 22210691 | ||
| 2173 | Phosphorylation | ALPLRGSTPEDAPAG CCCCCCCCCCCCCCC | 22210691 | ||
| 2203 | Phosphorylation | VAAPKTNSSTSPSLE CCCCCCCCCCCCCCC | 19664995 | ||
| 2204 | Phosphorylation | AAPKTNSSTSPSLET CCCCCCCCCCCCCCC | 19664995 | ||
| 2205 | Phosphorylation | APKTNSSTSPSLETR CCCCCCCCCCCCCCC | 19664995 | ||
| 2206 | Phosphorylation | PKTNSSTSPSLETRE CCCCCCCCCCCCCCC | 19664995 | ||
| 2211 | Phosphorylation | STSPSLETREPPGAP CCCCCCCCCCCCCCC | - | ||
| 2265 | Phosphorylation | ASRHGSPSRSARVPP CCCCCCCCCCCCCCC | 22210691 | ||
| 2278 | Phosphorylation | PPFNYVPSPMVVAAT CCCCCCCCCEEEEEE | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of APCL_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of APCL_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of APCL_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ACTS_HUMAN | ACTA1 | physical | 11691822 | |
| CTNB1_HUMAN | CTNNB1 | physical | 16510875 | |
| CTNB1_HUMAN | CTNNB1 | physical | 10074433 | |
| CTNB1_HUMAN | CTNNB1 | physical | 23840886 | |
| ASPP2_HUMAN | TP53BP2 | physical | 10646860 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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