MYOTI_HUMAN - dbPTM
MYOTI_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYOTI_HUMAN
UniProt AC Q9UBF9
Protein Name Myotilin
Gene Name MYOT
Organism Homo sapiens (Human).
Sequence Length 498
Subcellular Localization Cell membrane, sarcolemma . Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Sarcomeric, also localized to the sarcolemma (PubMed:10369880). Colocalizes with MYOZ1 at the Z-lines in skeletal muscle (PubMed:16076904).
Protein Description Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells..
Protein Sequence MFNYERPKHFIQSQNPCGSRLQPPGPETSSFSSQTKQSSIIIQPRQCTEQRFSASSTLSSHITMSSSAFPASPKQHAGSNPGQRVTTTYNQSPASFLSSILPSQPDYNSSKIPSAMDSNYQQSSAGQPINAKPSQTANAKPIPRTPDHEIQGSKEALIQDLERKLKCKDTLLHNGNQRLTYEEKMARRLLGPQNAAAVFQAQDDSGAQDSQQHNSEHARLQVPTSQVRSRSTSRGDVNDQDAIQEKFYPPRFIQVPENMSIDEGRFCRMDFKVSGLPAPDVSWYLNGRTVQSDDLHKMIVSEKGLHSLIFEVVRASDAGAYACVAKNRAGEATFTVQLDVLAKEHKRAPMFIYKPQSKKVLEGDSVKLECQISAIPPPKLFWKRNNEMVQFNTDRISLYQDNTGRVTLLIKDVNKKDAGWYTVSAVNEAGVTTCNTRLDVTARPNQTLPAPKQLRVRPTFSKYLALNGKGLNVKQAFNPEGEFQRLAAQSGLYESEEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20MethylationSQNPCGSRLQPPGPE
CCCCCCCCCCCCCCC		23.72-
30PhosphorylationPPGPETSSFSSQTKQ
CCCCCCCCCCCCCCC		36.2526437602
38PhosphorylationFSSQTKQSSIIIQPR
CCCCCCCCEEEECCC		25.6723909892
39PhosphorylationSSQTKQSSIIIQPRQ
CCCCCCCEEEECCCC		18.4726437602
88PhosphorylationPGQRVTTTYNQSPAS
CCCCEEEEECCCHHH		15.8819845377
92PhosphorylationVTTTYNQSPASFLSS
EEEEECCCHHHHHHH		20.8526437602
99PhosphorylationSPASFLSSILPSQPD
CHHHHHHHHCCCCCC		30.2319845377
107PhosphorylationILPSQPDYNSSKIPS
HCCCCCCCCCCCCCC		24.5119845377
109PhosphorylationPSQPDYNSSKIPSAM
CCCCCCCCCCCCCCC		27.1219845377
118PhosphorylationKIPSAMDSNYQQSSA
CCCCCCCCCCCCCCC		25.0925072903
120PhosphorylationPSAMDSNYQQSSAGQ
CCCCCCCCCCCCCCC		16.3325072903
123PhosphorylationMDSNYQQSSAGQPIN
CCCCCCCCCCCCCCC		13.4625072903
124PhosphorylationDSNYQQSSAGQPINA
CCCCCCCCCCCCCCC		31.8925072903
145PhosphorylationNAKPIPRTPDHEIQG
CCCCCCCCCCHHCCC		27.9326437602
153PhosphorylationPDHEIQGSKEALIQD
CCHHCCCCHHHHHHH		15.7922673903
180PhosphorylationHNGNQRLTYEEKMAR
CCCCCCCCHHHHHHH		30.9526437602
224PhosphorylationHARLQVPTSQVRSRS
HCEEECCHHHHHCCC		32.7026437602
225PhosphorylationARLQVPTSQVRSRST
CEEECCHHHHHCCCC		22.1726437602
229PhosphorylationVPTSQVRSRSTSRGD
CCHHHHHCCCCCCCC		31.5519764811
231PhosphorylationTSQVRSRSTSRGDVN
HHHHHCCCCCCCCCC		31.7919764811
232PhosphorylationSQVRSRSTSRGDVND
HHHHCCCCCCCCCCC		22.7219764811
233PhosphorylationQVRSRSTSRGDVNDQ
HHHCCCCCCCCCCCH		35.2019764811
272AcetylationRFCRMDFKVSGLPAP
CCCCCEEEECCCCCC		31.097378747
274PhosphorylationCRMDFKVSGLPAPDV
CCCEEEECCCCCCCE		34.89-
284PhosphorylationPAPDVSWYLNGRTVQ
CCCCEEEEECCEEEC		5.25-
289PhosphorylationSWYLNGRTVQSDDLH
EEEECCEEECCHHHH		25.0526437602
353PhosphorylationKRAPMFIYKPQSKKV
CCCCEEEECCCCCCE		12.8322817900
397PhosphorylationQFNTDRISLYQDNTG
EEECCEEEEEECCCC		23.1720068231
399PhosphorylationNTDRISLYQDNTGRV
ECCEEEEEECCCCCE		13.6620068231
403PhosphorylationISLYQDNTGRVTLLI
EEEEECCCCCEEEEE		34.3520068231
407PhosphorylationQDNTGRVTLLIKDVN
ECCCCCEEEEEEECC		17.9320068231
461PhosphorylationLRVRPTFSKYLALNG
EEECCCHHHHHHHCC		23.9126437602
463PhosphorylationVRPTFSKYLALNGKG
ECCCHHHHHHHCCCC		8.94-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseFBXO32Q969P5
PMID:15100091
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYOTI_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYOTI_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FLNC_HUMANFLNCphysical
11038172
MYOTI_HUMANMYOTphysical
11038172
A4_HUMANAPPphysical
21832049
TFG_HUMANTFGphysical
21988832
NDK7_HUMANNME7physical
25416956
Drug and Disease Associations
Kegg Disease
H00593 Limb-girdle muscular dystrophy (LGMD)
H00594 Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (T
H00595 Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myot
H01291 Spheroid body myopathy (SBM)
OMIM Disease
159000Limb-girdle muscular dystrophy 1A (LGMD1A)
609200Myopathy, myofibrillar, 3 (MFM3)
182920Spheroid body myopathy (SBM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYOTI_HUMAN

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Related Literatures of Post-Translational Modification

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