MAGC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGC2_HUMAN
• UniProt AC: Q9UBF1
• Protein Name: Melanoma-associated antigen C2
• Gene Name: MAGEC2
• Organism: Homo sapiens (Human).
• Sequence Length: 373
• Subcellular Localization: Cytoplasm . Nucleus . Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.
• Protein Description: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex..
• Protein Sequence: MPPVPGVPFRNVDNDSPTSVELEDWVDAQHPTDEEEEEASSASSTLYLVFSPSSFSTSSSLILGGPEEEEVPSGVIPNLTESIPSSPPQGPPQGPSQSPLSSCCSSFSWSSFSEESSSQKGEDTGTCQGLPDSESSFTYTLDEKVAELVEFLLLKYEAEEPVTEAEMLMIVIKYKDYFPVILKRAREFMELLFGLALIEVGPDHFCVFANTVGLTDEGSDDEGMPENSLLIIILSVIFIKGNCASEEVIWEVLNAVGVYAGREHFVYGEPRELLTKVWVQGHYLEYREVPHSSPPYYEFLWGPRAHSESIKKKVLEFLAKLNNTVPSSFPSWYKDALKDVEERVQATIDTADDATVMASESLSVMSSNVSFSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
174	Phosphorylation	MLMIVIKYKDYFPVI HEEHHHHHCCCHHHH	9.66	-
177	Phosphorylation	IVIKYKDYFPVILKR HHHHHCCCHHHHHHH	12.96	-
259	Phosphorylation	VLNAVGVYAGREHFV HHHHHCHHCCCCCEE	9.45	17053785
292	Phosphorylation	EYREVPHSSPPYYEF EEEECCCCCCCCHHH	38.17	26657352
293	Phosphorylation	YREVPHSSPPYYEFL EEECCCCCCCCHHHH	27.19	30266825
296	Phosphorylation	VPHSSPPYYEFLWGP CCCCCCCCHHHHCCC	21.00	30266825
297	Phosphorylation	PHSSPPYYEFLWGPR CCCCCCCHHHHCCCC	13.13	30266825
338	Ubiquitination	SWYKDALKDVEERVQ HHHHHHHHHHHHHHH	62.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TIF1B_HUMAN	TRIM28	physical	20864041
NSE4A_HUMAN	NSMCE4A	physical	21364888
EID3_HUMAN	EID3	physical	21364888
EID2_HUMAN	EID2	physical	21364888
TIF1B_HUMAN	TRIM28	physical	21277283
TIF1B_HUMAN	TRIM28	physical	23096706
ZMY11_HUMAN	ZMYND11	physical	24866244
TIF1B_HUMAN	TRIM28	physical	24866244
P4HA3_HUMAN	P4HA3	physical	25416956
PCGF6_HUMAN	PCGF6	physical	25590999
RN166_HUMAN	RNF166	physical	25590999
TRIM8_HUMAN	TRIM8	physical	25590999
RBX1_HUMAN	RBX1	physical	26540345
CUL1_HUMAN	CUL1	physical	26540345
MAT1_HUMAN	MNAT1	physical	25590999
TRAF4_HUMAN	TRAF4	physical	25590999
UBR3_HUMAN	UBR3	physical	25590999
TIF1B_HUMAN	TRIM28	physical	27775077
STAT3_HUMAN	STAT3	physical	27775077

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling.";
Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.;
EMBO J. 25:5058-5070(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-259, AND MASSSPECTROMETRY.
PubMed: 17053785