dbPTM

F117B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	F117B_HUMAN
UniProt AC	Q6P1L5
Protein Name	Protein FAM117B
Gene Name	FAM117B
Organism	Homo sapiens (Human).
Sequence Length	589
Subcellular Localization
Protein Description
Protein Sequence	MSQRVRRNGSPTPAGSLGGGAVATAGGPGSRLQPMRATVPFQLKQQQQQQHGSPTRSGGGGGGNNNGGCCGGASGPAGGGGGGGPRTASRSTSPTRGGGNAAARTSPTVATQTGASATSTRGTSPTRSAAPGARGSPPRPPPPPPLLGTVSSPSSSPTHLWTGEVSAAPPPARVRHRRRSPEQSRSSPEKRSPSAPVCKAGDKTRQPSSSPSSIIRRTSSLDTLAAPYLAGHWPRDSHGQAAPCMRDKATQTESAWAEEYSEKKKGSHKRSASWGSTDQLKEIAKLRQQLQRSKHSSRHHRDKERQSPFHGNHAAINQCQAPVPKSALIPVIPITKSTGSRFRNSVEGLNQEIEIIIKETGEKEEQLIPQDIPDGHRAPPPLVQRSSSTRSIDTQTPGGADRGSNNSSRSQSVSPTSFLTISNEGSEESPCSADDLLVDPRDKENGNNSPLPKYATSPKPNNSYMFKREPPEGCERVKVFEECSPKQLHEIPAFYCPDKNKVNFIPKSGSAFCLVSILKPLLPTPDLTLKGSGHSLTVTTGMTTTLLQPIAVASLSTNTEQDRVSRGTSTVMPSASLLPPPEPIEEAEG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	QRVRRNGSPTPAGSL CCCHHCCCCCCCCCC	29.20	29255136
12	Phosphorylation	VRRNGSPTPAGSLGG CHHCCCCCCCCCCCC	27.71	30266825
16	Phosphorylation	GSPTPAGSLGGGAVA CCCCCCCCCCCCCEE	26.41	23927012
24	Phosphorylation	LGGGAVATAGGPGSR CCCCCEECCCCCCCC	21.16	23927012
30	Phosphorylation	ATAGGPGSRLQPMRA ECCCCCCCCCCCEEE	32.71	23927012
38	Phosphorylation	RLQPMRATVPFQLKQ CCCCEEECCCCCHHH	20.53	-
44	Methylation	ATVPFQLKQQQQQQH ECCCCCHHHHHHHHC	34.97	-
53	Phosphorylation	QQQQQHGSPTRSGGG HHHHHCCCCCCCCCC	22.45	25849741
55	Phosphorylation	QQQHGSPTRSGGGGG HHHCCCCCCCCCCCC	38.88	30619164
87	Phosphorylation	GGGGGPRTASRSTSP CCCCCCCCCCCCCCC	31.92	20068231
89	Phosphorylation	GGGPRTASRSTSPTR CCCCCCCCCCCCCCC	26.59	20068231
91	Phosphorylation	GPRTASRSTSPTRGG CCCCCCCCCCCCCCC	30.64	30576142
92	Phosphorylation	PRTASRSTSPTRGGG CCCCCCCCCCCCCCC	37.30	20068231
93	Phosphorylation	RTASRSTSPTRGGGN CCCCCCCCCCCCCCC	26.06	30576142
95	Phosphorylation	ASRSTSPTRGGGNAA CCCCCCCCCCCCCCC	41.53	30576142
105	Phosphorylation	GGNAAARTSPTVATQ CCCCCCCCCCCEEEC	34.04	23927012
106	Phosphorylation	GNAAARTSPTVATQT CCCCCCCCCCEEECC	17.02	23927012
108	Phosphorylation	AAARTSPTVATQTGA CCCCCCCCEEECCCC	23.65	30266825
111	Phosphorylation	RTSPTVATQTGASAT CCCCCEEECCCCCCC	23.48	30266825
113	Phosphorylation	SPTVATQTGASATST CCCEEECCCCCCCCC	30.29	23403867
116	Phosphorylation	VATQTGASATSTRGT EEECCCCCCCCCCCC	33.16	23403867
118	Phosphorylation	TQTGASATSTRGTSP ECCCCCCCCCCCCCC	28.30	23403867
119	Phosphorylation	QTGASATSTRGTSPT CCCCCCCCCCCCCCC	18.80	23403867
120	Phosphorylation	TGASATSTRGTSPTR CCCCCCCCCCCCCCC	28.85	23403867
123	Phosphorylation	SATSTRGTSPTRSAA CCCCCCCCCCCCCCC	28.39	23090842
124	Phosphorylation	ATSTRGTSPTRSAAP CCCCCCCCCCCCCCC	27.39	24719451
126	Phosphorylation	STRGTSPTRSAAPGA CCCCCCCCCCCCCCC	36.70	23090842
128	Phosphorylation	RGTSPTRSAAPGARG CCCCCCCCCCCCCCC	31.12	28464451
136	Phosphorylation	AAPGARGSPPRPPPP CCCCCCCCCCCCCCC	26.61	28355574
149	Phosphorylation	PPPPLLGTVSSPSSS CCCCCCCEECCCCCC	19.72	25022875
151	Phosphorylation	PPLLGTVSSPSSSPT CCCCCEECCCCCCCC	36.05	28355574
152	Phosphorylation	PLLGTVSSPSSSPTH CCCCEECCCCCCCCE	25.19	25022875
154	Phosphorylation	LGTVSSPSSSPTHLW CCEECCCCCCCCEEE	45.45	28355574
155	Phosphorylation	GTVSSPSSSPTHLWT CEECCCCCCCCEEEC	43.66	30576142
156	Phosphorylation	TVSSPSSSPTHLWTG EECCCCCCCCEEECC	37.85	25022875
158	Phosphorylation	SSPSSSPTHLWTGEV CCCCCCCCEEECCEE	31.39	28464451
162	Phosphorylation	SSPTHLWTGEVSAAP CCCCEEECCEECCCC	29.80	30576142
166	Phosphorylation	HLWTGEVSAAPPPAR EEECCEECCCCCCHH	17.89	20873877
180	Phosphorylation	RVRHRRRSPEQSRSS HHCCCCCCHHHHCCC	30.86	30576142
184	Phosphorylation	RRRSPEQSRSSPEKR CCCCHHHHCCCCCCC	32.25	30576142
186	Phosphorylation	RSPEQSRSSPEKRSP CCHHHHCCCCCCCCC	56.33	29496963
187	Phosphorylation	SPEQSRSSPEKRSPS CHHHHCCCCCCCCCC	35.65	29496963
192	Phosphorylation	RSSPEKRSPSAPVCK CCCCCCCCCCCCCCC	33.98	30266825
194	Phosphorylation	SPEKRSPSAPVCKAG CCCCCCCCCCCCCCC	46.59	23401153
204	Phosphorylation	VCKAGDKTRQPSSSP CCCCCCCCCCCCCCH	39.00	23312004
208	Phosphorylation	GDKTRQPSSSPSSII CCCCCCCCCCHHHHH	34.80	22167270
209	Phosphorylation	DKTRQPSSSPSSIIR CCCCCCCCCHHHHHH	53.61	22167270
210	Phosphorylation	KTRQPSSSPSSIIRR CCCCCCCCHHHHHHH	32.89	22167270
212	Phosphorylation	RQPSSSPSSIIRRTS CCCCCCHHHHHHHHC	35.80	22167270
213	Phosphorylation	QPSSSPSSIIRRTSS CCCCCHHHHHHHHCC	25.97	22167270
218	Phosphorylation	PSSIIRRTSSLDTLA HHHHHHHHCCCHHHH	16.90	22617229
219	Phosphorylation	SSIIRRTSSLDTLAA HHHHHHHCCCHHHHH	27.39	24260401
220	Phosphorylation	SIIRRTSSLDTLAAP HHHHHHCCCHHHHHH	29.65	25159151
223	Phosphorylation	RRTSSLDTLAAPYLA HHHCCCHHHHHHHHC	24.48	21712546
228	Phosphorylation	LDTLAAPYLAGHWPR CHHHHHHHHCCCCCC	12.40	23403867
252	Phosphorylation	MRDKATQTESAWAEE CCCCHHHCHHHHHHH	27.79	-
261	Phosphorylation	SAWAEEYSEKKKGSH HHHHHHHHHHCCCCC	46.34	-
267	Phosphorylation	YSEKKKGSHKRSASW HHHHCCCCCCCCCCC	34.41	-
271	Phosphorylation	KKGSHKRSASWGSTD CCCCCCCCCCCCCHH	31.30	30266825
273	Phosphorylation	GSHKRSASWGSTDQL CCCCCCCCCCCHHHH	32.96	19664994
273 (in isoform 2)	Phosphorylation	-	32.96	22468782
276	Phosphorylation	KRSASWGSTDQLKEI CCCCCCCCHHHHHHH	23.66	30266825
277	Phosphorylation	RSASWGSTDQLKEIA CCCCCCCHHHHHHHH	24.67	30266825
307	Phosphorylation	HRDKERQSPFHGNHA HHHHHHCCCCCCCHH	35.44	25159151
335	O-linked_Glycosylation	LIPVIPITKSTGSRF EEEEEEECCCCCHHH	17.37	23301498
345	Phosphorylation	TGSRFRNSVEGLNQE CCHHHHHHHHCHHHE	19.79	22617229
386	Phosphorylation	PPPLVQRSSSTRSID CCCCCCCCCCCCCCC	16.14	25159151
387	Phosphorylation	PPLVQRSSSTRSIDT CCCCCCCCCCCCCCC	37.61	25159151
388	Phosphorylation	PLVQRSSSTRSIDTQ CCCCCCCCCCCCCCC	29.14	30576142
389	Phosphorylation	LVQRSSSTRSIDTQT CCCCCCCCCCCCCCC	30.31	30576142
391	Phosphorylation	QRSSSTRSIDTQTPG CCCCCCCCCCCCCCC	25.55	25159151
394	Phosphorylation	SSTRSIDTQTPGGAD CCCCCCCCCCCCCCC	32.45	30576142
396	Phosphorylation	TRSIDTQTPGGADRG CCCCCCCCCCCCCCC	26.45	29255136
404	Phosphorylation	PGGADRGSNNSSRSQ CCCCCCCCCCCCCCC	33.46	23663014
407	Phosphorylation	ADRGSNNSSRSQSVS CCCCCCCCCCCCCCC	31.23	23663014
408	Phosphorylation	DRGSNNSSRSQSVSP CCCCCCCCCCCCCCC	37.77	23663014
410	Phosphorylation	GSNNSSRSQSVSPTS CCCCCCCCCCCCCCC	28.84	29978859
412	Phosphorylation	NNSSRSQSVSPTSFL CCCCCCCCCCCCCEE	26.30	28464451
414	Phosphorylation	SSRSQSVSPTSFLTI CCCCCCCCCCCEEEE	27.92	28102081
416	Phosphorylation	RSQSVSPTSFLTISN CCCCCCCCCEEEECC	25.30	28387310
417	Phosphorylation	SQSVSPTSFLTISNE CCCCCCCCEEEECCC	22.95	28464451
420	Phosphorylation	VSPTSFLTISNEGSE CCCCCEEEECCCCCC	21.98	28464451
422	Phosphorylation	PTSFLTISNEGSEES CCCEEEECCCCCCCC	24.48	29978859
426	Phosphorylation	LTISNEGSEESPCSA EEECCCCCCCCCCCH	31.82	29978859
429	Phosphorylation	SNEGSEESPCSADDL CCCCCCCCCCCHHHC	27.44	29978859
432	Phosphorylation	GSEESPCSADDLLVD CCCCCCCCHHHCCCC	37.81	29978859
449	Phosphorylation	DKENGNNSPLPKYAT CCCCCCCCCCCCCCC	31.64	23401153
454	Phosphorylation	NNSPLPKYATSPKPN CCCCCCCCCCCCCCC	17.11	21712546
456	Phosphorylation	SPLPKYATSPKPNNS CCCCCCCCCCCCCCC	42.33	25159151
457	Phosphorylation	PLPKYATSPKPNNSY CCCCCCCCCCCCCCC	23.82	25159151
463	Phosphorylation	TSPKPNNSYMFKREP CCCCCCCCCCCCCCC	25.31	28102081
464	Phosphorylation	SPKPNNSYMFKREPP CCCCCCCCCCCCCCC	14.54	26074081
467	Ubiquitination	PNNSYMFKREPPEGC CCCCCCCCCCCCCCC	39.04	-
478	Ubiquitination	PEGCERVKVFEECSP CCCCCEEEEEECCCH	47.64	-
484	Phosphorylation	VKVFEECSPKQLHEI EEEEECCCHHHHHCC	38.11	25159151
486	Ubiquitination	VFEECSPKQLHEIPA EEECCCHHHHHCCCE	49.55	-
499	Ubiquitination	PAFYCPDKNKVNFIP CEEECCCCCCEEEEC	43.75	-
501	Ubiquitination	FYCPDKNKVNFIPKS EECCCCCCEEEECCC	44.27	-
508	Phosphorylation	KVNFIPKSGSAFCLV CEEEECCCCCCCHHH	32.40	26074081
510	Phosphorylation	NFIPKSGSAFCLVSI EEECCCCCCCHHHHH	25.84	26074081
516	Phosphorylation	GSAFCLVSILKPLLP CCCCHHHHHHHCCCC	14.84	24719451
524	Phosphorylation	ILKPLLPTPDLTLKG HHHCCCCCCCEEECC	29.42	26853621
532	Phosphorylation	PDLTLKGSGHSLTVT CCEEECCCCCCEEEE	31.57	22210691
543	Phosphorylation	LTVTTGMTTTLLQPI EEEECCCCHHCCEEE	20.27	22210691
568	Phosphorylation	QDRVSRGTSTVMPSA CHHHCCCCCCCCCCH	21.80	-
569	Phosphorylation	DRVSRGTSTVMPSAS HHHCCCCCCCCCCHH	23.10	-
574	Phosphorylation	GTSTVMPSASLLPPP CCCCCCCCHHHCCCC	16.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of F117B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of F117B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of F117B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNKS1_HUMAN	TNKS	physical	28514442
DYR1B_HUMAN	DYRK1B	physical	28514442
IMP1L_HUMAN	IMMP1L	physical	28514442
TNKS2_HUMAN	TNKS2	physical	28514442
DYR1A_HUMAN	DYRK1A	physical	28514442
T22D2_HUMAN	TSC22D2	physical	28514442
FNTB_HUMAN	FNTB	physical	28514442
T22D3_HUMAN	TSC22D3	physical	28514442
PNMA2_HUMAN	PNMA2	physical	28514442
NRBP_HUMAN	NRBP1	physical	28514442
G3PT_HUMAN	GAPDHS	physical	28514442
A16A1_HUMAN	ALDH16A1	physical	28514442
FNTA_HUMAN	FNTA	physical	28514442
DYL1_HUMAN	DYNLL1	physical	28514442
DYL1_HUMAN	DYNLL1	physical	27173435
DYL2_HUMAN	DYNLL2	physical	27173435
DCAF7_HUMAN	DCAF7	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of F117B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-391, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219 AND SER-220, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-218; SER-219 ANDSER-220, AND MASS SPECTROMETRY.	18220336 [Abstract]