dbPTM

T22D2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	T22D2_HUMAN
UniProt AC	O75157
Protein Name	TSC22 domain family protein 2
Gene Name	TSC22D2
Organism	Homo sapiens (Human).
Sequence Length	780
Subcellular Localization
Protein Description
Protein Sequence	MSKMPAKKKSCFQITSVTTAQVATSITEDTESLDDPDESRTEDVSSEIFDVSRATDYGPEEVCERSSSEETLNNVGDAETPGTVSPNLLLDGQLAAAAAAPANGGGVVSARSVSGALASTLAAAATSAPAPGAPGGPQLAGSSAGPVTAAPSQPPTTCSSRFRVIKLDHGSGEPYRRGRWTCMEYYERDSDSSVLTRSGDCIRHSSTFDQTAERDSGLGATGGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQPPLSLIAENKPVVKPPVADSLANPLQLTPMNSLATSVFSIAIPVDGDEDRNPSTAFYQAFHLNTLKESKSLWDSASGGGVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPTQQANPGSTSQQQAVIAQPPQPTQPPQQPNVSSA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	ESRTEDVSSEIFDVS CCCCCCHHHHHHCHH	34.28	30266825
46	Phosphorylation	SRTEDVSSEIFDVSR CCCCCHHHHHHCHHH	34.26	30266825
52	Phosphorylation	SSEIFDVSRATDYGP HHHHHCHHHHHCCCH	20.31	21815630
55	Phosphorylation	IFDVSRATDYGPEEV HHCHHHHHCCCHHHH	28.75	21815630
57	Phosphorylation	DVSRATDYGPEEVCE CHHHHHCCCHHHHHH	30.17	26552605
66	Phosphorylation	PEEVCERSSSEETLN HHHHHHCCCCCCHHH	18.87	30624053
67	Phosphorylation	EEVCERSSSEETLNN HHHHHCCCCCCHHHC	48.25	30624053
68	Phosphorylation	EVCERSSSEETLNNV HHHHCCCCCCHHHCC	40.47	30624053
71	Phosphorylation	ERSSSEETLNNVGDA HCCCCCCHHHCCCCC	30.63	30624053
80	Phosphorylation	NNVGDAETPGTVSPN HCCCCCCCCCCCCCC	28.83	30624053
83	Phosphorylation	GDAETPGTVSPNLLL CCCCCCCCCCCCEEE	21.00	30624053
85	Phosphorylation	AETPGTVSPNLLLDG CCCCCCCCCCEEECC	14.12	30624053
112	Phosphorylation	GGVVSARSVSGALAS CCEEEEEEHHHHHHH	21.98	28348404
114	Phosphorylation	VVSARSVSGALASTL EEEEEEHHHHHHHHH	21.42	28348404
171	Phosphorylation	VIKLDHGSGEPYRRG EEEECCCCCCCCCCC	36.24	27732954
181	Phosphorylation	PYRRGRWTCMEYYER CCCCCEEEEEEEEEC	10.70	-
190	Phosphorylation	MEYYERDSDSSVLTR EEEEECCCCCCEEEC	45.68	28674419
192	Phosphorylation	YYERDSDSSVLTRSG EEECCCCCCEEECCC	26.71	-
193	Phosphorylation	YERDSDSSVLTRSGD EECCCCCCEEECCCC	26.57	28857561
196	Phosphorylation	DSDSSVLTRSGDCIR CCCCCEEECCCCCCC	22.19	27251275
198	Phosphorylation	DSSVLTRSGDCIRHS CCCEEECCCCCCCCC	33.47	23403867
205	Phosphorylation	SGDCIRHSSTFDQTA CCCCCCCCCCCCCCC	22.64	22617229
206	Phosphorylation	GDCIRHSSTFDQTAE CCCCCCCCCCCCCCC	27.28	23403867
207	Phosphorylation	DCIRHSSTFDQTAER CCCCCCCCCCCCCCC	33.96	30108239
240	Phosphorylation	QGAHGPESGTDSSLT CCCCCCCCCCCCCCC	50.56	27251275
242	Phosphorylation	AHGPESGTDSSLTAV CCCCCCCCCCCCCCH	41.82	27251275
244	Phosphorylation	GPESGTDSSLTAVSQ CCCCCCCCCCCCHHC	27.38	27251275
245	Phosphorylation	PESGTDSSLTAVSQL CCCCCCCCCCCHHCC	32.33	27251275
247	Phosphorylation	SGTDSSLTAVSQLPP CCCCCCCCCHHCCCC	27.28	27251275
538	O-linked_Glycosylation	VPAPLAQSQQLSSHT CCCCHHHHHHHHCCC	17.81	OGP
542	Phosphorylation	LAQSQQLSSHTPVSR HHHHHHHHCCCCCCC	18.74	26503514
543	Phosphorylation	AQSQQLSSHTPVSRS HHHHHHHCCCCCCCC	39.72	26503514
548	O-linked_Glycosylation	LSSHTPVSRSSSIIQ HHCCCCCCCCCHHHH	27.87	23301498
548	Phosphorylation	LSSHTPVSRSSSIIQ HHCCCCCCCCCHHHH	27.87	26503514
550	O-linked_Glycosylation	SHTPVSRSSSIIQHV CCCCCCCCCHHHHHC	22.41	23301498
550	Phosphorylation	SHTPVSRSSSIIQHV CCCCCCCCCHHHHHC	22.41	18669648
551	O-linked_Glycosylation	HTPVSRSSSIIQHVG CCCCCCCCHHHHHCC	25.17	23301498
551	Phosphorylation	HTPVSRSSSIIQHVG CCCCCCCCHHHHHCC	25.17	26699800
552	Phosphorylation	TPVSRSSSIIQHVGL CCCCCCCHHHHHCCC	25.59	25394399
552	O-linked_Glycosylation	TPVSRSSSIIQHVGL CCCCCCCHHHHHCCC	25.59	23301498
565	Phosphorylation	GLPLAPGTHSAPTSL CCCCCCCCCCCCCCC	16.17	26699800
567	Phosphorylation	PLAPGTHSAPTSLPQ CCCCCCCCCCCCCCH	35.46	29496963
570	O-linked_Glycosylation	PGTHSAPTSLPQSDL CCCCCCCCCCCHHHH	42.48	23301498
570	Phosphorylation	PGTHSAPTSLPQSDL CCCCCCCCCCCHHHH	42.48	26699800
571	O-linked_Glycosylation	GTHSAPTSLPQSDLS CCCCCCCCCCHHHHH	36.67	23301498
571	Phosphorylation	GTHSAPTSLPQSDLS CCCCCCCCCCHHHHH	36.67	26699800
575	O-linked_Glycosylation	APTSLPQSDLSQFQT CCCCCCHHHHHHCHH	38.28	23301498
575	Phosphorylation	APTSLPQSDLSQFQT CCCCCCHHHHHHCHH	38.28	26699800
578	Phosphorylation	SLPQSDLSQFQTQTQ CCCHHHHHHCHHHCC	33.66	21406692
582	Phosphorylation	SDLSQFQTQTQPLVG HHHHHCHHHCCCCCC	34.57	21406692
584	Phosphorylation	LSQFQTQTQPLVGQV HHHCHHHCCCCCCCC	35.23	21406692
594	Phosphorylation	LVGQVDDTRRKSEPL CCCCCCCCCCCCCCC	28.10	26074081
598	Phosphorylation	VDDTRRKSEPLPQPP CCCCCCCCCCCCCCC	42.51	25849741
607	Phosphorylation	PLPQPPLSLIAENKP CCCCCCCCCEECCCC	24.41	26074081
674 (in isoform 2)	Ubiquitination	-	7.28	21890473
689 (in isoform 2)	Ubiquitination	-	43.82	21890473
694	Sulfoxidation	DNKIEQAMDLVKSHL CCHHHHHHHHHHHHH	4.01	21406390
698 (in isoform 1)	Ubiquitination	-	39.18	21890473
698	Ubiquitination	EQAMDLVKSHLMYAV HHHHHHHHHHHHHHH	39.18	-
699	Phosphorylation	QAMDLVKSHLMYAVR HHHHHHHHHHHHHHH	17.86	20068231
703	Phosphorylation	LVKSHLMYAVREEVE HHHHHHHHHHHHHHH	14.33	20068231
713	Ubiquitination	REEVEVLKEQIKELV HHHHHHHHHHHHHHH	53.39	-
713 (in isoform 1)	Ubiquitination	-	53.39	21890473
724	Phosphorylation	KELVERNSLLERENA HHHHHHHCHHHHHHH	40.32	23911959
778	O-linked_Glycosylation	PPQQPNVSSA----- CCCCCCCCCC-----	27.47	23301498
779	O-linked_Glycosylation	PQQPNVSSA------ CCCCCCCCC------	33.44	23301498

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of T22D2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of T22D2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of T22D2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KEAP1_HUMAN	KEAP1	physical	23382044
RING2_HUMAN	RNF2	physical	27337956
WNK3_HUMAN	WNK3	physical	27337956
OSBL1_HUMAN	OSBPL1A	physical	27337956
PSA7_HUMAN	PSMA7	physical	27337956
ZN143_HUMAN	ZNF143	physical	27337956
NRBP_HUMAN	NRBP1	physical	27337956
FLNB_HUMAN	FLNB	physical	27337956
TILB_HUMAN	LRRC6	physical	27337956
MPDZ_HUMAN	MPDZ	physical	27337956
REV1_HUMAN	REV1	physical	27337956
TITIN_HUMAN	TTN	physical	27337956
MEP50_HUMAN	WDR77	physical	27337956
CC141_HUMAN	CCDC141	physical	27337956
C144A_HUMAN	CCDC144A	physical	27337956
TALD3_HUMAN	KIAA0586	physical	27337956
ANM3_HUMAN	PRMT3	physical	27337956
SNX3_HUMAN	SNX3	physical	27337956
SPEF2_HUMAN	SPEF2	physical	27337956
TMA7_HUMAN	TMA7	physical	27337956
APC10_HUMAN	ANAPC10	physical	27337956
AN36A_HUMAN	ANKRD36	physical	27337956
ARID2_HUMAN	ARID2	physical	27337956
AT1B1_HUMAN	ATP1B1	physical	27337956
CLIP1_HUMAN	CLIP1	physical	27337956
ENOPH_HUMAN	ENOPH1	physical	27337956
EPCAM_HUMAN	EPCAM	physical	27337956
FA8_HUMAN	F8	physical	27337956
GPBP1_HUMAN	GPBP1	physical	27337956
ITA2_HUMAN	ITGA2	physical	27337956
LOXH1_HUMAN	LOXHD1	physical	27337956
LIPL_HUMAN	LPL	physical	27337956
MED13_HUMAN	MED13	physical	27337956
MSH3_HUMAN	MSH3	physical	27337956
IF2M_HUMAN	MTIF2	physical	27337956
NGRN_HUMAN	NGRN	physical	27337956
PSA7L_HUMAN	PSMA8	physical	27337956
RBL1_HUMAN	RBL1	physical	27337956
SAP18_HUMAN	SAP18	physical	27337956
SCEL_HUMAN	SCEL	physical	27337956
SC31A_HUMAN	SEC31A	physical	27337956
STK39_HUMAN	STK39	physical	27337956
UFM1_HUMAN	UFM1	physical	27337956
ZMYM2_HUMAN	ZMYM2	physical	27337956
ZN251_HUMAN	ZNF251	physical	27337956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of T22D2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-598, AND MASSSPECTROMETRY.	19413330 [Abstract]