CC141_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC141_HUMAN
• UniProt AC: Q6ZP82
• Protein Name: Coiled-coil domain-containing protein 141
• Gene Name: CCDC141
• Organism: Homo sapiens (Human).
• Sequence Length: 1450
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Co-localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner.
• Protein Description: Plays a critical role in radial migration and centrosomal function..
• Protein Sequence: MSSQGSPSVALSTTTVSSVAVQAGDSKIVIAVIKCGKWVQLQLAESQPNLLEIGSSQDETKKLLHDHELLLAKLKALEDRVWELLQEADKTAEENKDQSQVYDAMAETLGEAWAALVSMLERRTELLRLTSEFFENALEFAIKIDQAEDFLQNTHEFESAESLKSLLQLHEHHTKELLERSLALLNKSQQLTDFIEKFKCEGPNVNPELTQGAHSSCLKVDRLLELLQDRRRQLDKYLKQQWQELSQVLQICQWDQQENQVTCWFQKTIRNLQEQSLGSSLSDNEDRIHKQEELIIKAKEWNSAVEKLKSEALRILLSKDYVEKEHLQLSHQKLSQLQEEFGQLMVERNTWLKKANEFFNSANKAFDVLGRVEAYLKLLKSEGLSLAVLAVRHEELHRKIKDCTTDALQKGQTLISQVDSCSSQVSGIHEMMGCIKRRVDHLTEQCSAHKEYALKKQQLTASVEGYLRKVEMSIQKISPVLSNAMDVGSTRSESEKILNKYLELDIQAKETSHELEAAAKTMMEKNEFVSDEMVSLSSKARWLAEELNLFGQSIDYRSQVLQTYVAFLKSSEEVEMQFQSLKEFYETEIPQKEQDDAKAKHCSDSAEKQWQLFLKKSFITQDLGLEFLNLINMAKENEILDVKNEVYLMKNTMENQKAEREELSLLRLAWQLKATESKPGKQQWAAFKEQLKKTSHNLKLLQEALMPVSALDLGGSLQFILDLRQKWNDMKPQFQQLNDEVQYIMKESEELTGRGAPVKEKSQQLKDLIHFHQKQKERIQDYEDILYKVVQFHQVKEELGRLIKSRELEFVEQPKELGDAHDVQIHLRCSQEKQARVDHLHRLALSLGVDIISSVQRPHCSNVSAKNLQQQLELLEEDSMKWRAKAEEYGRTLSRSVEYCAMRDEINELKDSFKDIKKKFNNLKFNYTKKNEKSRNLKALKYQIQQVDMYAEKMQALKRKMEKVSNKTSDSFLNYPSDKVNVLLEVMKDLQKHVDDFDKVVTDYKKNLDLTEHFQEVIEECHFWYEDASATVVRVGKYSTECKTKEAVKILHQQFNKFIAPSVPQQEERIQEATDLAQHLYGLEEGQKYIEKIVTKHKEVLESVTELCESLTELEEKLKQGDVLKMNPNLEDFHYDYIDLLKEPAKNKQTIFNEERNKGQVQVADLLGINGTGEERLPQDLKVSTDKEGGVQDLLLPEDMLSGEEYECVSPDDISLPPLPGSPESPLAPSDMEVEEPVSSSLSLHISSYGVQAGTSSPGDAQESVLPPPVAFADACNDKRETFSSHFERPYLQFKAEPPLTSRGFVEKSTALHRISAEHPESMMSEVHERALQQHPQAQGGLLETREKMHADNNFTKTQDRLHASSDAFSGLRFQSGTSRGYQRQMVPREEIKSTSAKSSVVSLADQAPNFSRLLSNVTVMEGSPVTLEVEVTGFPEPTLTWWVAYNDKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSQGSPSV ------CCCCCCCCE	45.12	25693802
3	Phosphorylation	-----MSSQGSPSVA -----CCCCCCCCEE	5.27	25693802
6	Phosphorylation	--MSSQGSPSVALST --CCCCCCCCEECCC	4.24	25693802
8	Phosphorylation	MSSQGSPSVALSTTT CCCCCCCCEECCCCE	59.77	25693802
12	Phosphorylation	GSPSVALSTTTVSSV CCCCEECCCCEEEEE	28.03	25693802
13	Phosphorylation	SPSVALSTTTVSSVA CCCEECCCCEEEEEE	40.51	25693802
14	Phosphorylation	PSVALSTTTVSSVAV CCEECCCCEEEEEEE	5.98	25693802
15	Phosphorylation	SVALSTTTVSSVAVQ CEECCCCEEEEEEEE	32.72	25693802
17	Phosphorylation	ALSTTTVSSVAVQAG ECCCCEEEEEEEECC	52.57	25693802
18	Phosphorylation	LSTTTVSSVAVQAGD CCCCEEEEEEEECCC	54.73	25693802
26	Phosphorylation	VAVQAGDSKIVIAVI EEEECCCCEEEEEEE	22.60	25693802
46	Phosphorylation	VQLQLAESQPNLLEI HHHHHHHCCCCEECC	38.83	29888752
55	Phosphorylation	PNLLEIGSSQDETKK CCEECCCCCHHHHHH	3.05	29888752
56	Phosphorylation	NLLEIGSSQDETKKL CEECCCCCHHHHHHH	3.01	29888752
60	Phosphorylation	IGSSQDETKKLLHDH CCCCHHHHHHHHCCH	50.75	29888752
159	Phosphorylation	QNTHEFESAESLKSL HHCCCCCCHHHHHHH	7.29	24719451
321	Phosphorylation	RILLSKDYVEKEHLQ HHHHCCHHHHHHHHH	18.87	29083192
330	Phosphorylation	EKEHLQLSHQKLSQL HHHHHHHCHHHHHHH	37.03	29083192
490	Phosphorylation	NAMDVGSTRSESEKI HCCCCCCCCCHHHHH	62.25	28176443
492	Phosphorylation	MDVGSTRSESEKILN CCCCCCCCHHHHHHH	43.95	28176443
494	Phosphorylation	VGSTRSESEKILNKY CCCCCCHHHHHHHHH	34.83	28176443
537	Phosphorylation	SDEMVSLSSKARWLA CHHHHHHHHHHHHHH	48.04	-
580	Phosphorylation	EVEMQFQSLKEFYET HHHHHHHHHHHHHHC	63.76	24719451
694	Phosphorylation	FKEQLKKTSHNLKLL HHHHHHHHHHHHHHH	28.29	26270265
695	Phosphorylation	KEQLKKTSHNLKLLQ HHHHHHHHHHHHHHH	9.37	26270265
716	Phosphorylation	SALDLGGSLQFILDL HHHHHCCHHHHHHHH	21.25	-
873 (in isoform 2)	Ubiquitination	-	52.51	-
879	Phosphorylation	LELLEEDSMKWRAKA HHHHHHHHHHHHHHH		27174698
910	Acetylation	RDEINELKDSFKDIK HHHHHHHHHHHHHHH		7932631
917	Acetylation	KDSFKDIKKKFNNLK HHHHHHHHHHHHHCC		7932639
965	Phosphorylation	KRKMEKVSNKTSDSF HHHHHHHHCCCCCCH		26074081
968	Phosphorylation	MEKVSNKTSDSFLNY HHHHHCCCCCCHHCC		26074081
969	Phosphorylation	EKVSNKTSDSFLNYP HHHHCCCCCCHHCCC		26074081
971	Phosphorylation	VSNKTSDSFLNYPSD HHCCCCCCHHCCCHH		26074081
975	Phosphorylation	TSDSFLNYPSDKVNV CCCCHHCCCHHHHHH		26074081
977	Phosphorylation	DSFLNYPSDKVNVLL CCHHCCCHHHHHHHH		26074081
1005	Acetylation	DKVVTDYKKNLDLTE HHHHHHHHHHCCCHH		30587501
1006	Acetylation	KVVTDYKKNLDLTEH HHHHHHHHHCCCHHH		30587497
1044	Phosphorylation	KYSTECKTKEAVKIL ECCCCCCHHHHHHHH		30301811
1112	Phosphorylation	TELCESLTELEEKLK HHHHHHHHHHHHHHH		19413330
1291	Phosphorylation	SSHFERPYLQFKAEP HHHCCCCCEECCCCC		-
1301	Phosphorylation	FKAEPPLTSRGFVEK CCCCCCCCCCCCCCH		28857561
1302	Phosphorylation	KAEPPLTSRGFVEKS CCCCCCCCCCCCCHH		28857561
1345	Phosphorylation	AQGGLLETREKMHAD HCCCHHHHHHHHHCC		30622161
1356	Phosphorylation	MHADNNFTKTQDRLH HHCCCCCCCCHHHHH		23403867
1400	Phosphorylation	KSTSAKSSVVSLADQ CCCCCCHHHHHHHHC		-
1424	Phosphorylation	NVTVMEGSPVTLEVE CCEEECCCCEEEEEE		-
1448	Ubiquitination	TWWVAYNDKP----- EEEEEECCCC-----		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC141_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC141_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC141_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CC141_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.