LOXH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LOXH1_HUMAN
• UniProt AC: Q8IVV2
• Protein Name: Lipoxygenase homology domain-containing protein 1
• Gene Name: LOXHD1
• Organism: Homo sapiens (Human).
• Sequence Length: 1947
• Subcellular Localization: Cell projection, stereocilium.
• Protein Description: Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity)..
• Protein Sequence: MMQLTLNTLFPVVSTPAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGGVFDRGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNNKWFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARVYMQIYGEKGKTEVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFVDTVWLRHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKEYTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETGNGGETRENVWLILEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYFFNCDCLIPLKRKRKYFKVFEVTKTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLELVVTRLGLAAECG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MMQLTLNTLFPV ---CCCEEHHHHCCC	10.89	24043423
5 (in isoform 5)	Phosphorylation	-	10.89	22210691
5 (in isoform 4)	Phosphorylation	-	10.89	22210691
8	Phosphorylation	MMQLTLNTLFPVVST CCCEEHHHHCCCCCC	32.65	24043423
14	Phosphorylation	NTLFPVVSTPAITYI HHHCCCCCCCCEEEE	28.98	24043423
15 (in isoform 5)	Phosphorylation	-	12.72	22210691
15	Phosphorylation	TLFPVVSTPAITYIV HHCCCCCCCCEEEEE	12.72	24043423
15 (in isoform 4)	Phosphorylation	-	12.72	22210691
19	Phosphorylation	VVSTPAITYIVTVFT CCCCCCEEEEEEEEC	14.86	24043423
20 (in isoform 5)	Phosphorylation	-	6.31	22210691
20	Phosphorylation	VSTPAITYIVTVFTG CCCCCEEEEEEEECC	6.31	24043423
20 (in isoform 4)	Phosphorylation	-	6.31	22210691
22 (in isoform 4)	Phosphorylation	-	2.35	22210691
22 (in isoform 5)	Phosphorylation	-	2.35	22210691
23	Phosphorylation	PAITYIVTVFTGDVR CCEEEEEEEECCCCC	10.59	24043423
26	Phosphorylation	TYIVTVFTGDVRGAG EEEEEEECCCCCCCC	28.30	24043423
27 (in isoform 4)	Phosphorylation	-	21.68	22210691
27 (in isoform 5)	Phosphorylation	-	21.68	22210691
28 (in isoform 5)	Phosphorylation	-	24.71	22210691
28 (in isoform 4)	Phosphorylation	-	24.71	22210691
39	Phosphorylation	AGTKSKIYLVMYGAR CCCCCEEEEEEEECC	9.29	-
81	Phosphorylation	AVLLSPLSRVSVGHG HHHHCCCCCCCCCCC	33.74	18669648
219	Phosphorylation	RVWHDKRSSGSGWHL EEEECCCCCCCCEEH	44.80	25002506
220	Phosphorylation	VWHDKRSSGSGWHLE EEECCCCCCCCEEHH	40.80	25002506
222	Phosphorylation	HDKRSSGSGWHLERM ECCCCCCCCEEHHHH	40.43	25002506
230	Phosphorylation	GWHLERMTLMNTLNK CEEHHHHHHHHCCCC	29.13	25002506
301	Phosphorylation	NVYLCLFGDVGDTGE EEEEEEECCCCCHHC	18.75	-
304	Phosphorylation	LCLFGDVGDTGERLL EEEECCCCCHHCHHH	31.35	-
351	Phosphorylation	IRHDGKGSGSGWYLD EEECCCCCCCCEEEE	33.02	28842319
408	Phosphorylation	ATLKNFRYHISLKTG CCCCEEEEEEEEECC	10.20	29759185
411	Phosphorylation	KNFRYHISLKTGDVS CEEEEEEEEECCCCC	15.53	24719451
414	Phosphorylation	RYHISLKTGDVSGAS EEEEEEECCCCCCCC	43.86	-
418	Phosphorylation	SLKTGDVSGASTDSR EEECCCCCCCCCCCE	33.12	-
421	Phosphorylation	TGDVSGASTDSRVYI CCCCCCCCCCCEEEE	35.95	-
422	Phosphorylation	GDVSGASTDSRVYIK CCCCCCCCCCEEEEE	37.14	-
431	Phosphorylation	SRVYIKLYGDKSDTI CEEEEEEECCCCCCE	20.48	-
483 (in isoform 5)	Phosphorylation	-	2.12	24719451
487 (in isoform 5)	Phosphorylation	-	8.02	24719451
527	Phosphorylation	LEVELYPSEVVEIQK EEEEEECHHEEEEEE	29.48	23403867
538	Phosphorylation	EIQKLVHYEVEIWTG EEEEEEEEEEEEEEC	17.75	-
552	Phosphorylation	GDVGGAGTSARVYMQ CCCCCCCCEEEEEEE	20.76	-
553	Phosphorylation	DVGGAGTSARVYMQI CCCCCCCEEEEEEEE	17.11	23403867
631	Phosphorylation	VVREVDLTPEEEARK HEEECCCCHHHHHHH	24.96	24114839
787	Phosphorylation	PLKKSDKSNKFEQGQ CCCCCCCCCCCCCCC	50.68	-
809	Phosphorylation	AIDLGALTKIRIRHD EEECCCEEEEEEECC	24.72	24719451
920	Phosphorylation	TDANVFITLFGTQDD CCCEEEEEEEEECCC	12.45	-
928	Phosphorylation	LFGTQDDTGMTLLKS EEEECCCCCCCEEEC	36.82	-
1009	Phosphorylation	AKNEDDGSIIRDLFH CCCCCCCCHHHHHHH	23.10	-
1087	Phosphorylation	SASRFIVELEDVGEI CCCEEEEEEHHHHHH	41.44	-
1141	Phosphorylation	PCDRWLATSEDDKKT ECCCCCCCCCCCHHH	30.40	29978859
1142	Phosphorylation	CDRWLATSEDDKKTI CCCCCCCCCCCHHHH	33.16	29978859
1155	Phosphorylation	TIRELVPYDIFTEKY HHHHHCCHHHHCHHH	17.75	-
1203	Phosphorylation	AGTDAKVYITIYGDL CCCCCEEEEEEEECC	7.52	29396449
1205	Phosphorylation	TDAKVYITIYGDLGD CCCEEEEEEEECCCC	7.17	29396449
1207	Phosphorylation	AKVYITIYGDLGDTG CEEEEEEEECCCCHH	8.92	29396449
1213	Phosphorylation	IYGDLGDTGERYLGK EEECCCCHHCEECCC	38.86	29396449
1217	Phosphorylation	LGDTGERYLGKSENR CCCHHCEECCCCCCC	18.59	29396449
1482	Phosphorylation	NIGVKVLYEMTVWTG HCCCEEEEEEEEECC	13.47	26552605
1485	Phosphorylation	VKVLYEMTVWTGDVV CEEEEEEEEECCCEE	10.84	26552605
1488	Phosphorylation	LYEMTVWTGDVVGGG EEEEEEECCCEECCC	21.11	26552605
1496	Phosphorylation	GDVVGGGTDSNIFMT CCEECCCCCCCEEEE	39.26	26552605
1498	Phosphorylation	VVGGGTDSNIFMTLY EECCCCCCCEEEEEE	31.50	26552605
1503	Phosphorylation	TDSNIFMTLYGINGS CCCCEEEEEEECCCC	13.18	26552605
1505	Phosphorylation	SNIFMTLYGINGSTE CCEEEEEEECCCCHH	13.54	26552605
1510	Phosphorylation	TLYGINGSTEEMQLD EEEECCCCHHHHHHH	28.32	26552605
1511	Phosphorylation	LYGINGSTEEMQLDK EEECCCCHHHHHHHH	37.05	26552605
1530	Phosphorylation	FEREQNDTFIMEILD HHHHHCCCEEEEHHH	23.70	-
1644	Acetylation	DSGTLALKQSANWNK CCCCEEEECCCCCCC	36.28	19821033
2038	Phosphorylation	-------------------------------------------------------------------------------------------------- --------------------------------------------------------------------------------------------------		24719451
2042	Phosphorylation	------------------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------------------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LOXH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LOXH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LOXH1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LOXH1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.