C144A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C144A_HUMAN
• UniProt AC: A2RUR9
• Protein Name: Coiled-coil domain-containing protein 144A
• Gene Name: CCDC144A
• Organism: Homo sapiens (Human).
• Sequence Length: 1427
• Protein Sequence: MASWGGEKRGGAEGSPKPAVYATRKTPSVGSQGDQWYLGYPGDQWSSGFPYSWWKNSVGSESKHGEGALDQPQHDVRLEDLGELHRAARSGDVPGVEHILAPGDTGVDKRDRKKSIQQLVPEYKEKQTPESLPQNNNPDWHPTNLTLSDETCQRSKNLKVDDKCPSVSPSMPENQSATKELGQMNLTEREKMDTGVVLLSGNDTLHDLCQSQLPENKESKEAEQDSELTSEEEQERLKGCENKQPQKTSQEPEMAKDCDREDIPIYPVLPHVQKSEEMWIEQGKLEWKNQLKLVINELKQRFGEIYEKYKIPACPEEEPLLDNSTRGTDVKDIPFNLTNNIPGCEEEDASEISVSVVFETFPEQKEPSLKNIIHPYYHPYSGSQEHVCQSSSKFHLHENKLDCDNDNKPGIGHIFSTDKNFHNDASTKKARNPEVVMVEMKEDQEFDLQMTKNMNQNSDSGSTNNYKSLKPKLENLSSLPPDSDRTSEVYLHEELQQDMQKFKNEVNTLEEEFLALKKEDVQLHKDVEEEMEKHRSNSTELSGTLTDGTTVGNDDDGLNQQIPRKENGEHDRPADKTSNEKNEVKNQIYPEADFADSMEPSEIASEDCELSHSVYENFMLLIEQLRMEYKDSASLPRIQDTFCLCEHLLKLKNNHCDQLTVKLKQMENMVSVLQNELSETKKTKLQLELQKIEWEKELYDLRLALKQENEEKRNADMLYNKDSEQLRIKEEECGKVVETKQQLKWNLRRLVKELRTVRNNLDLVVQERNDAQKQLSEEQDARILQDQILTSKQKELEMARKKMNSEISHRHQKEKDLFHEDCMLQEEIALLRLEIDTIKNQNKQKEKKYFEDIEAVKEKNDNLQKIIKLNEETLTETILQYSGQLNNLTAENKILNSELENGKQNQERLEIEMESYRCRLAAAVRDCDQSQTARDLKLDFQRTRQEWVRLHDKMKVDMSGLQAKNEILSEKLSNAESKINSLQIQLHNTRDALGRESLILERVQRDLSQTQCQKKETEQMYQIEQSKLKKYIAKQESVEERLSQLQSENMLLRQQLDDAHKKANSQEKTSSTIQDQFHSAAKNLQAESEKQILSLQEKNKELMDEYNHLKERMDQCEKEKAGRKIDLTEAQETVPSRCLHLDAENEVLQLQQTLFSMKAIQKQCETLQKNKKQLKQEVVNLKSYMERNMLERGKAEWHKLLIEERARKEIEEKLNEAILTLQKQAAVSHEQLVQLREDNTTSIKTQMELTIKDLESEISRIKTSQADFNKTELERYKELYLEEVKVRESLSNELSRTNEMIAEVSTQLTVEKEQTRSRSLFTAYATRPVLESPCVGNLNDSEGLNRKHIPRKKRSALKDMESYLLKMQQKLQNDLTAEVAGSSQTGLHRIPQCSSFSSSSLHLLLCSICQPFFLILQLLLNMNLDPI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	Phosphorylation	HILAPGDTGVDKRDR EECCCCCCCCCHHHH	45.05	-
115	Phosphorylation	DKRDRKKSIQQLVPE CHHHHHHHHHHHHHH	28.76	26852163
176	Phosphorylation	PSMPENQSATKELGQ CCCCCCHHHHHHHHC	49.87	-
451	Phosphorylation	QEFDLQMTKNMNQNS CCEEHHHCCCCCCCC	13.30	29978859
458	Phosphorylation	TKNMNQNSDSGSTNN CCCCCCCCCCCCCCC	24.32	29978859
460	Phosphorylation	NMNQNSDSGSTNNYK CCCCCCCCCCCCCHH	34.17	29978859
462	Phosphorylation	NQNSDSGSTNNYKSL CCCCCCCCCCCHHHC	31.73	29978859
463	Phosphorylation	QNSDSGSTNNYKSLK CCCCCCCCCCHHHCH	30.89	29978859
466	Phosphorylation	DSGSTNNYKSLKPKL CCCCCCCHHHCHHHH	12.20	29978859
468	Phosphorylation	GSTNNYKSLKPKLEN CCCCCHHHCHHHHHC	31.12	29978859
483	Phosphorylation	LSSLPPDSDRTSEVY HHCCCCCCCCCCHHH	34.46	28111955
629	Phosphorylation	IEQLRMEYKDSASLP HHHHHHHCCCCCCCC	15.68	-
632	Phosphorylation	LRMEYKDSASLPRIQ HHHHCCCCCCCCCHH	18.66	23401153
634	Phosphorylation	MEYKDSASLPRIQDT HHCCCCCCCCCHHHH	42.74	23401153
660	Phosphorylation	NNHCDQLTVKLKQME CCCCCHHHHHHHHHH	15.23	-
721	Acetylation	NADMLYNKDSEQLRI CHHHHCCCCHHHHHC	49.42	164021
729	Acetylation	DSEQLRIKEEECGKV CHHHHHCCHHHHCHH	53.27	164023
790	Phosphorylation	ILQDQILTSKQKELE HHHHHHHHHHHHHHH	35.19	24043423
791	Phosphorylation	LQDQILTSKQKELEM HHHHHHHHHHHHHHH	29.64	24043423
837	Phosphorylation	LLRLEIDTIKNQNKQ HHHHHHHHHHHCCHH	39.24	23403867
839	Ubiquitination	RLEIDTIKNQNKQKE HHHHHHHHHCCHHHH	55.35	-
955	Ubiquitination	VRLHDKMKVDMSGLQ HHHHHHHCCCCCHHH	40.60	18655026
969	Phosphorylation	QAKNEILSEKLSNAE HHHHHHHHHHHCCHH	38.04	24719451
1008	Phosphorylation	ERVQRDLSQTQCQKK HHHHHHHHHHHHHHH	35.16	23401153
1031	Phosphorylation	EQSKLKKYIAKQESV HHHHHHHHHHHHHCH	12.43	-
1037	Phosphorylation	KYIAKQESVEERLSQ HHHHHHHCHHHHHHH	32.13	26852163
1043	Phosphorylation	ESVEERLSQLQSENM HCHHHHHHHHHHHHH	34.76	-
1128	Phosphorylation	AGRKIDLTEAQETVP CCCCCCCHHHHHHCC	26.06	29978859
1133	Phosphorylation	DLTEAQETVPSRCLH CCHHHHHHCCCCCEE	26.15	29978859
1136	Phosphorylation	EAQETVPSRCLHLDA HHHHHCCCCCEECHH	31.15	29978859
1156	Phosphorylation	QLQQTLFSMKAIQKQ HHHHHHHHHHHHHHH	23.61	24719451
1241	Phosphorylation	QLREDNTTSIKTQME HHHHCCCCCCEEEEE	34.41	30576142
1245	Phosphorylation	DNTTSIKTQMELTIK CCCCCCEEEEEEEHH	31.32	22210691
1250	Phosphorylation	IKTQMELTIKDLESE CEEEEEEEHHHHHHH	16.81	22210691
1256	Phosphorylation	LTIKDLESEISRIKT EEHHHHHHHHHHHHH	47.75	22210691
1362	Phosphorylation	SALKDMESYLLKMQQ HHHHHHHHHHHHHHH	17.91	24719451
1363	Phosphorylation	ALKDMESYLLKMQQK HHHHHHHHHHHHHHH	11.62	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C144A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C144A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C144A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of C144A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Ubiquitylation

"Proteomic analysis of ubiquitinated proteins in normal hepatocytecell line Chang liver cells.";
Tan F., Lu L., Cai Y., Wang J., Xie Y., Wang L., Gong Y., Xu B.-E.,Wu J., Luo Y., Qiang B., Yuan J., Sun X., Peng X.;
Proteomics 8:2885-2896(2008).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-955, AND MASSSPECTROMETRY.
PubMed: 18655026