| UniProt ID | TILB_HUMAN | |
|---|---|---|
| UniProt AC | Q86X45 | |
| Protein Name | Protein tilB homolog | |
| Gene Name | LRRC6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 466 | |
| Subcellular Localization | Cytoplasm . Cell projection, cilium . | |
| Protein Description | May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility.. | |
| Protein Sequence | MGWITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALNVNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVDVQPTYVRVMIKGKPFQLVLPAEVKPDSSSAKRSQTTGHLVICMPKVGEVITGGQRAFKSMKTTSDRSREQTNTRSKHMEKLEVDPSKHSFPDVTNIVQEKKHTPRRRPEPKIIPSEEDPTFEDNPEVPPLI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MGWITEDLIRRN ---CCCCHHHHHHHC | 19.55 | 24043423 | |
| 50 | Phosphorylation | CRDLKILYLQNNLIG HHHHHHHHHHCCHHH | 15.09 | 30622161 | |
| 70 | Phosphorylation | SKLKKLEYLNLALNN HHHHHHHHHHHHHHC | 16.01 | 19835603 | |
| 104 | Phosphorylation | VNFIGELSSIKNLQH EEHHHHHHHHCCCCC | 26.22 | 24719451 | |
| 131 | Phosphorylation | PCASFDHYREFVVAT CCCCCHHHHHHHHHH | 17.43 | - | |
| 202 | Phosphorylation | DKNEDKRSNAGFDGR CCCHHHHHCCCCCCC | 36.45 | 30242111 | |
| 224 | Sumoylation | TLSSLESKDHLQAPD HHHHHHCCCCCCCCC | 39.53 | - | |
| 243 | Phosphorylation | NTKKLDNSEDDLEFW CCCCCCCCCCHHHHC | 41.91 | 24719451 | |
| 326 | Phosphorylation | LDLAVYRYMDTSLID EEHHHHHHCCCCCCC | 5.01 | 29507054 | |
| 339 | Phosphorylation | IDVDVQPTYVRVMIK CCCCCCCCEEEEEEC | 19.98 | 29507054 | |
| 363 | Phosphorylation | AEVKPDSSSAKRSQT CEECCCCCCCCCCCC | 41.52 | 25332170 | |
| 364 | Phosphorylation | EVKPDSSSAKRSQTT EECCCCCCCCCCCCC | 41.58 | 25332170 | |
| 424 | Phosphorylation | EVDPSKHSFPDVTNI CCCCCCCCCCCHHHH | 42.06 | 23401153 | |
| 438 | Phosphorylation | IVQEKKHTPRRRPEP HHHHCCCCCCCCCCC | 27.63 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TILB_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TILB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TILB_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SCRIB_HUMAN | SCRIB | physical | 25036637 | |
| CYBP_HUMAN | CACYBP | physical | 26344197 | |
| SCRIB_HUMAN | SCRIB | physical | 28514442 | |
| PHLP2_HUMAN | PHLPP2 | physical | 28514442 | |
| CHK1_HUMAN | CHEK1 | physical | 28514442 | |
| DHYS_HUMAN | DHPS | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 614935 | Ciliary dyskinesia, primary, 19 (CILD19) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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