AN36A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AN36A_HUMAN
• UniProt AC: A6QL64
• Protein Name: Ankyrin repeat domain-containing protein 36A
• Gene Name: ANKRD36
• Organism: Homo sapiens (Human).
• Sequence Length: 1941
• Protein Sequence: MEDGKRERWPTLMERLCSDGFAFPQYPIKPYHLKRIHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNAIDYLGRSALIHAVTLGEKDIVILLLQHNIDVLSRDAFRKIAGDYAIEAKNRVIFDLIYEYERKRYEDLPINSNPVSSQKQPALKATSGKEDSISNIATEIKDGQKSGTVSSQKQPALKDTSDKDDSVSNTATEIKDEQKSGTVLPAVEQCLNRSLYRPDAVAQPVTENEFSLESEIISKLYIPKRKIISPRSIKDVLPPVEEAVDRCLYLLDRFAQPVTKDKFALESENISEPYFTNRRTISQQSAENLDAACGIDKTENGNMFEDQNVDKEGKALPATGQKANVSPEQPPLFTHTVKDRDHISTRFLGGMDSLTSSEESSERPPLSTLTLKEADPSSKAAMRRKDSPPPGKVSSQKQPAEKATSDDKDSVSNIATEIKEGPISGTVSSQKQPAEKATSDEKDSVSNIATEIKKGQQSGTVSPQKQSAWKVIFKKKVSLLNIATRIMGGGKSGTVSSQKQPASKATSDKTDSALNIATEIKDGLQCGTVSSQKQPALKATTDEEDSVSNIATEIKDGEKSGTVSSQKQPALKATTDEEDSVSNIATEIKDGEKSGTVSSQKQPALKATTDEKDSVSNIATEIKDGEKSGTVSSQKPPALTATSDEEGSVLSIARENKDGEKSRTVSSRKKPALKATSDEKDSFSNITRGKKDGEISRKVSSQKPPTLKGTSDEEDSVLGIARENKDGEKSRTVSSEKPPGLKASSAEKDSVLNIARGKKDGEKTKRVSSRKKPSLEATSDEKDSFSNITREKKDGEISRKVSSQKPPALKGTSDEEDSVLGIARENKDGEKSRTVSSEKPPGLKATSDEKDSVLNIARGKKDGEKTRTVSSQKPPTLKATSDEEDSVLSIARENKDGEKSRTVSSEKPSGLKATSAEKDSVLNIARGKKYGEKTKRVSSRKKPALKATSDEKDSVLYIAREKKDGEKSRTVSSPKQPALKAICDKEDSVPNMATEKKDEQISGTVSCQKQPALKATSDKKDSVSNIPTEIKDGQQSGTVSSQKQPAWKATSVKKDSVSNIATEIKDGQIRGTGILEYTFNVMFDQIEEKFTSLNKSAGVSPQKQSAQKVIFKKKVSLLNIATRITGGWKSGTEYPENLPTLKATIENKNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRLEEYENNQPQVKNQIHSRDDLDDIIQSSQTVSEDGDSLCCNCKNVILLIDQHEMKCKDCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKILQHSSLMLQVFES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29 (in isoform 4)	Ubiquitination	-	34.71	-
29	Ubiquitination	AFPQYPIKPYHLKRI CCCCCCCCHHHHHHH	34.71	-
60 (in isoform 4)	Ubiquitination	-	58.35	-
60	Ubiquitination	LTYYDANKRDRKERT HHHHCCCCCCHHHHH	58.35	-
86	Phosphorylation	EMVHLLVSRRCELNL HHHHHHHHCCCCCCC	17.61	24719451
100	Phosphorylation	LCDREDRTPLIKAVQ CCCCCCCCHHHHHHH	34.47	24719451
162 (in isoform 4)	Ubiquitination	-	42.62	-
195	Phosphorylation	ANVNAIDYLGRSALI CCCCHHHHCCHHHHH	12.63	142707
257	Phosphorylation	YEYERKRYEDLPINS HHHHHHHHHCCCCCC	19.48	27642862
278	Phosphorylation	KQPALKATSGKEDSI CCCCHHCCCCCCCHH	36.10	20860994
298	Phosphorylation	EIKDGQKSGTVSSQK EECCCCCCCCCCCCC	31.63	-
300	Phosphorylation	KDGQKSGTVSSQKQP CCCCCCCCCCCCCCC	25.06	-
302	Phosphorylation	GQKSGTVSSQKQPAL CCCCCCCCCCCCCCC	27.21	-
303	Phosphorylation	QKSGTVSSQKQPALK CCCCCCCCCCCCCCC	36.74	-
381	Phosphorylation	IPKRKIISPRSIKDV CCCCCCCCCCCHHHH	20.10	23927012
384	Phosphorylation	RKIISPRSIKDVLPP CCCCCCCCHHHHCCC	37.06	22617229
478	Phosphorylation	TGQKANVSPEQPPLF CCCCCCCCCCCCCCE	23.64	30266825
539	Phosphorylation	AAMRRKDSPPPGKVS HHHHCCCCCCCCCCC	42.20	26657352
610	Phosphorylation	EIKKGQQSGTVSPQK HHHCCCCCCCCCCCC	28.66	29396449
612	Phosphorylation	KKGQQSGTVSPQKQS HCCCCCCCCCCCCCC	24.06	29396449
614	Phosphorylation	GQQSGTVSPQKQSAW CCCCCCCCCCCCCHH	22.81	-
630	Phosphorylation	VIFKKKVSLLNIATR HHHHHHHHHHHHHHH	35.70	19413330
636	Phosphorylation	VSLLNIATRIMGGGK HHHHHHHHHHCCCCC	19.55	21964256
644	Phosphorylation	RIMGGGKSGTVSSQK HHCCCCCCCCCCCCC	42.86	19413330
649	Phosphorylation	GKSGTVSSQKQPASK CCCCCCCCCCCCCCC	36.74	-
662	Phosphorylation	SKATSDKTDSALNIA CCCCCCCCCHHHHHH	39.93	27251275
664	Phosphorylation	ATSDKTDSALNIATE CCCCCCCHHHHHHHH	39.63	28985074
670	Phosphorylation	DSALNIATEIKDGLQ CHHHHHHHHHCCCCC	34.15	28985074
818	Phosphorylation	GEKSRTVSSRKKPAL CCCCCCCCCCCCCCC	24.66	22210691
819	Phosphorylation	EKSRTVSSRKKPALK CCCCCCCCCCCCCCC	43.73	22210691
862	Phosphorylation	KPPTLKGTSDEEDSV CCCCCCCCCCCCCCH	31.27	28348404
863	Phosphorylation	PPTLKGTSDEEDSVL CCCCCCCCCCCCCHH	52.25	28348404
886	Phosphorylation	GEKSRTVSSEKPPGL CCCCCCCCCCCCCCC	31.97	27251275
887	Phosphorylation	EKSRTVSSEKPPGLK CCCCCCCCCCCCCCC	45.35	27251275
920	Phosphorylation	GEKTKRVSSRKKPSL CCHHHCCCCCCCCCC	28.58	29759185
921	Phosphorylation	EKTKRVSSRKKPSLE CHHHCCCCCCCCCCC	45.31	29759185
926	Phosphorylation	VSSRKKPSLEATSDE CCCCCCCCCCCCCCC	47.96	29759185
930	Phosphorylation	KKPSLEATSDEKDSF CCCCCCCCCCCCCCC	27.60	46501295
931	Phosphorylation	KPSLEATSDEKDSFS CCCCCCCCCCCCCCC	51.31	29759185
964	Phosphorylation	KPPALKGTSDEEDSV CCCCCCCCCCHHHCH	31.27	28348404
965	Phosphorylation	PPALKGTSDEEDSVL CCCCCCCCCHHHCHH	52.25	28348404
988	Phosphorylation	GEKSRTVSSEKPPGL CCCCEEECCCCCCCC	31.97	27251275
989	Phosphorylation	EKSRTVSSEKPPGLK CCCEEECCCCCCCCC	45.35	27251275
1032	Phosphorylation	KPPTLKATSDEEDSV CCCCEECCCCCCCCH	34.81	27794612
1033	Phosphorylation	PPTLKATSDEEDSVL CCCEECCCCCCCCHH	48.13	27794612
1038	Phosphorylation	ATSDEEDSVLSIARE CCCCCCCCHHHHCCC	28.39	27794612
1041	Phosphorylation	DEEDSVLSIARENKD CCCCCHHHHCCCCCC	16.43	27794612
1056	Phosphorylation	GEKSRTVSSEKPSGL CCCCCCCCCCCCCCC	31.97	27251275
1057	Phosphorylation	EKSRTVSSEKPSGLK CCCCCCCCCCCCCCC	45.35	27251275
1120	Phosphorylation	EKKDGEKSRTVSSPK ECCCCCCCCCCCCCC	28.96	24850871
1122	Phosphorylation	KDGEKSRTVSSPKQP CCCCCCCCCCCCCCH	31.65	27134283
1124	Phosphorylation	GEKSRTVSSPKQPAL CCCCCCCCCCCCHHH	40.07	24850871
1125	Phosphorylation	EKSRTVSSPKQPALK CCCCCCCCCCCHHHH	31.60	27134283
1154	Phosphorylation	EKKDEQISGTVSCQK CCCCCCCCCCCCCCC	28.27	29083192
1156	Phosphorylation	KDEQISGTVSCQKQP CCCCCCCCCCCCCCC	11.49	29083192
1158	Phosphorylation	EQISGTVSCQKQPAL CCCCCCCCCCCCCCC	15.63	29083192
1168	Phosphorylation	KQPALKATSDKKDSV CCCCCCCCCCCCCCC	35.55	6589893
1169	Phosphorylation	QPALKATSDKKDSVS CCCCCCCCCCCCCCC	52.90	6589885
1180	Phosphorylation	DSVSNIPTEIKDGQQ CCCCCCCCEEECCCC	46.69	23025827
1188	Phosphorylation	EIKDGQQSGTVSSQK EEECCCCCCCCCCCC	28.66	23879269
1192	Phosphorylation	GQQSGTVSSQKQPAW CCCCCCCCCCCCCCC	27.21	23879269
1203	Phosphorylation	QPAWKATSVKKDSVS CCCCCCCCCCCCHHH	36.48	18452278
1214	Phosphorylation	DSVSNIATEIKDGQI CHHHHHEEEEECCCC	34.15	18452278
1268	Phosphorylation	VIFKKKVSLLNIATR HHHHHHHHHHHHHHC	35.70	-
1274	Phosphorylation	VSLLNIATRITGGWK HHHHHHHHCCCCCCC	20.86	21964256
1277	Phosphorylation	LNIATRITGGWKSGT HHHHHCCCCCCCCCC	26.76	-
1296	Phosphorylation	NLPTLKATIENKNSV CCCCHHHHHHCCCHH	27.51	25072903
1302	Phosphorylation	ATIENKNSVLNTATK HHHHCCCHHHHHCHH	29.59	25072903
1306	Phosphorylation	NKNSVLNTATKMKDV CCCHHHHHCHHHHCC	31.38	25072903
1308	Phosphorylation	NSVLNTATKMKDVQT CHHHHHCHHHHCCCC	29.63	25072903
1316	Phosphorylation	KMKDVQTSTPAEQDL HHHCCCCCCCHHHHH	18.46	24114839
1729	Phosphorylation	MKDIEKMYKSGYNTM HHHHHHHHHHCHHHH	17.05	11021523
1735	Phosphorylation	MYKSGYNTMEKCIEK HHHHCHHHHHHHHHH	20.44	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AN36A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AN36A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AN36A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AN36A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.