AFG1L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AFG1L_HUMAN
• UniProt AC: Q8WV93
• Protein Name: AFG1-like ATPase {ECO:0000312|HGNC:HGNC:16411}
• Gene Name: AFG1L {ECO:0000312|HGNC:HGNC:16411}
• Organism: Homo sapiens (Human).
• Sequence Length: 481
• Subcellular Localization: Mitochondrion membrane .
• Protein Description: Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. [PubMed: 26759378]
• Protein Sequence: MAASWSLLVTLRPLAQSPLRGRCVGCGAWAAALAPLATAPGKPFWKAYTVQTSESMTPTATSETYLKALAVCHGPLDHYDFLIKAHELKDDEHQRRVIQCLQKLHEDLKGYNIEAEGLFSKLFSRSKPPRGLYVYGDVGTGKTMVMDMFYAYVEMKRKKRVHFHGFMLDVHKRIHRLKQSLPKRKPGFMAKSYDPIAPIAEEISEEACLLCFDEFQVTDIADAMILKQLFENLFKNGVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKEYCNTVQLDSGIDYRKRELPAAGKLYYLTSEADVEAVMDKLFDELAQKQNDLTRPRILKVQGRELRLNKACGTVADCTFEELCERPLGASDYLELSKNFDTIFLRNIPQFTLANRTQGRRFITLIDNFYDLKVRIICSASTPISSLFLHQHHDSELEQSRILMDDLGLSQDSAEGLSMFTGEEEIFAFQRTISRLTEMQTEQYWNEGDRTKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAASWSLLVTL ----CCCCEEEEEEH		24043423
6	Phosphorylation	--MAASWSLLVTLRP --CCCCEEEEEEHHH		24043423
10	Phosphorylation	ASWSLLVTLRPLAQS CCEEEEEEHHHHCCC		24043423
17	Phosphorylation	TLRPLAQSPLRGRCV EHHHHCCCCCCCCCC		24043423
120	Phosphorylation	IEAEGLFSKLFSRSK CCHHHHHHHHHCCCC		24719451
133	Phosphorylation	SKPPRGLYVYGDVGT CCCCCEEEEEEECCC		-
135	Phosphorylation	PPRGLYVYGDVGTGK CCCEEEEEEECCCCC		30576142
140	Phosphorylation	YVYGDVGTGKTMVMD EEEEECCCCCHHHHH		-
143	Phosphorylation	GDVGTGKTMVMDMFY EECCCCCHHHHHHHH		30576142
150	Phosphorylation	TMVMDMFYAYVEMKR HHHHHHHHHHHHHHH		24719451
152	Phosphorylation	VMDMFYAYVEMKRKK HHHHHHHHHHHHHCC		30576142
156	Acetylation	FYAYVEMKRKKRVHF HHHHHHHHHCCCCEE		30589801
180	Phosphorylation	RIHRLKQSLPKRKPG HHHHHHHHCCCCCCC		24719451
295	Phosphorylation	LPAAGKLYYLTSEAD CCCCCEEEEECCHHH		-
296	Phosphorylation	PAAGKLYYLTSEADV CCCCEEEEECCHHHH		-
438	Phosphorylation	LMDDLGLSQDSAEGL HHHHCCCCCCCCCCH		23879269
441	Phosphorylation	DLGLSQDSAEGLSMF HCCCCCCCCCCHHCC		23879269
449	Phosphorylation	AEGLSMFTGEEEIFA CCCHHCCCCHHHHHH		23879269

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AFG1L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AFG1L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AFG1L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AFG1L_HUMAN	LACE1	physical	27499296
XPP3_HUMAN	XPNPEP3	physical	27499296
ECH1_HUMAN	ECH1	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
DDAH1_HUMAN	DDAH1	physical	27499296

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.