AVT6_YEAST - dbPTM
AVT6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AVT6_YEAST
UniProt AC P40074
Protein Name Vacuolar amino acid transporter 6
Gene Name AVT6
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 448
Subcellular Localization Vacuole membrane
Multi-pass membrane protein .
Protein Description Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting aspartate and glutamate. Requires ATP for function..
Protein Sequence MVASIRSGVLTLLHTACGAGILAMPYAFKPFGLIPGVIMIVLCGACAMQSLFIQARVAKYVPQGRASFSALTRLINPNLGIVFDLAIAIKCFGVGVSYMIVVGDLMPQIMSVWTRNAWLLNRNVQISLIMLFFVAPLSFLKKLNSLRYASMVAISSVAYLCVLVLLHYVAPSDEILRLKGRISYLLPPQSHDLNVLNTLPIFVFAYTCHHNMFSIINEQRSSRFEHVMKIPLIAISLALILYIAIGCAGYLTFGDNIIGNIIMLYPQAVSSTIGRIAIVLLVMLAFPLQCHPARASIHQILQHFAEENVSISATSADEPTVATESSPLIRDSSLDLNEVIEEESIYQPKETPLRGKSFIVITCSILVASYLVAISVSSLARVLAIVGATGSTSISFILPGLFGYKLIGTEHKTAVPLTTKIFKYTGLLLFIWGLIIMITCLTAALKLN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
97PhosphorylationKCFGVGVSYMIVVGD
HHHCCCCEEEEECCC		11.7630377154
111PhosphorylationDLMPQIMSVWTRNAW
CCHHHHHHHHHHHHH		19.0130377154
114PhosphorylationPQIMSVWTRNAWLLN
HHHHHHHHHHHHHHC		16.3430377154
325PhosphorylationEPTVATESSPLIRDS
CCCCCCCCCCCCCCC		32.6628889911
326PhosphorylationPTVATESSPLIRDSS
CCCCCCCCCCCCCCC		19.9327214570
332PhosphorylationSSPLIRDSSLDLNEV
CCCCCCCCCCCHHHH		23.9730377154
333PhosphorylationSPLIRDSSLDLNEVI
CCCCCCCCCCHHHHH		30.1427214570
344PhosphorylationNEVIEEESIYQPKET
HHHHHHHHCCCCCCC		29.8521082442
346PhosphorylationVIEEESIYQPKETPL
HHHHHHCCCCCCCCC		28.2129688323
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AVT6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AVT6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AVT6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
INV2_YEASTSUC2genetic
21623372
LPP1_YEASTLPP1genetic
21623372
PYRD_YEASTURA1genetic
21623372
POS5_YEASTPOS5genetic
21623372
ALAT_YEASTALT2genetic
21623372
COX9_YEASTCOX9genetic
21623372
FOLE_YEASTMET7genetic
21623372
DCE_YEASTGAD1genetic
21623372
TPS1_YEASTTPS1genetic
21623372
CYS3_YEASTCYS3genetic
21623372
BDH1_YEASTBDH1genetic
21623372
UGPA2_YEASTYHL012Wgenetic
21623372
LAC1_YEASTLAC1genetic
21623372
DS1P2_YEASTYSR3genetic
21623372
PGLR_YEASTPGU1genetic
21623372
GLRX2_YEASTGRX2genetic
21623372
DCI1_YEASTDCI1genetic
21623372
TPS2_YEASTTPS2genetic
21623372
XRN1_YEASTXRN1genetic
27708008
YBQ3_YEASTYBR053Cgenetic
27708008
RDH54_YEASTRDH54genetic
27708008
MDM34_YEASTMDM34genetic
27708008
MRT4_YEASTMRT4genetic
27708008
ELM1_YEASTELM1genetic
27708008
KAPC_YEASTTPK3genetic
27708008
ROM2_YEASTROM2genetic
27708008
ELP1_YEASTIKI3genetic
27708008
OCA1_YEASTOCA1genetic
27708008
PPQ1_YEASTPPQ1genetic
27708008
CR3L1_HUMANCREB3L1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AVT6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325; SER-326 ANDSER-344, AND MASS SPECTROMETRY.

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