SCE2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCE2_YEAST
• UniProt AC: P03878
• Protein Name: Intron-encoded DNA endonuclease aI4
• Gene Name: AI4
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 556
• Subcellular Localization: Mitochondrion.
• Protein Description: Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break at the junction of the two exons a4-a5 of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with limited specificity and cleaves the sequence 5'-TTTGGTCACCCTGAAGTA-3'. The protein may acquire mRNA maturase activity, like the closely related bI4, through a single amino acid substitution Glu-362 to Lys or when present together with a mutant form of the imported mitochondrial leucyl-tRNA synthetase NAM2..
• Protein Sequence: MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGQTVATIIMLMMYNDMHFSKCWKLLKKWITNIMSTLFKALFVKMFMSYNNQQDKMMNNTMLKKDNIKRSSETTRKMLNNSMNKKFNQWLAGLIDGDGYFGIVSKKYVSLEITVALEDEMALKEIQNKFGGSIKLRSGVKAIRYRLTNKTGMIKLINAVNGNIRNTKRLVQFNKVCILLGIDFIYPIKLTKDNSWFVGFFDADGTINYSFKNNHPQLTISVTNKYLQDVQEYKNILGGNIYFDKSQNGYYKWSIQSKDMVLNFINDYIKMNPSRTTKMNKLYLSKEFYNLKELKAYNKSSDSMQYKAWLNFENKWKNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	AKDIAVLYFMLAIFS HHHHHHHHHHHHHHC	4.75	30377154
25	Phosphorylation	YFMLAIFSGMAGTAM HHHHHHHCCCCHHHH	22.88	30377154
33	Phosphorylation	GMAGTAMSLIIRLEL CCCHHHHHHHHHHHH	17.60	30377154
308	Phosphorylation	KKDNIKRSSETTRKM CHHHCCCCHHHHHHH	27.76	27017623
311	Phosphorylation	NIKRSSETTRKMLNN HCCCCHHHHHHHHHH	33.57	27017623
312	Phosphorylation	IKRSSETTRKMLNNS CCCCHHHHHHHHHHH	25.00	27017623
345	Phosphorylation	FGIVSKKYVSLEITV EEEEECEEEEEEEEE	10.06	27017623
351	Phosphorylation	KYVSLEITVALEDEM EEEEEEEEEEECCHH	7.14	27017623
518	Acetylation	SRTTKMNKLYLSKEF CCCCCCCEEHHCHHH	34.70	25381059
529	Acetylation	SKEFYNLKELKAYNK CHHHCCHHHHHHCCC	58.31	24489116
529	Succinylation	SKEFYNLKELKAYNK CHHHCCHHHHHHCCC	58.31	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCE2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCE2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCE2_YEAST !!

Protein-Protein Interaction

Oops, there are no PPI records of SCE2_YEAST !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.