SCE4_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCE4_YEAST
• UniProt AC: Q9ZZX1
• Protein Name: Intron-encoded DNA endonuclease aI5 alpha
• Gene Name: AI5_ALPHA
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 630
• Subcellular Localization: Mitochondrion . Membrane ; Multi-pass membrane protein .
• Protein Description: Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with limited specificity and cleaves the sequence 5'-ATCTTCTCTTGATTAGCCCTGATCTACGG-3' after the nucleotide sequence ATTA leaving a four-base overhang and a 3'-OH..
• Protein Sequence: MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFFLVMPALIGGFGNYLLPLMIGATDTAFPRINNIAFWVLPMGLVCLVTSTLVESGAGTGWTVYPPLSSIQAHSGPSVDLAIFALHLTSISSLLGAINFIVTTLNMRTNGMTMHKLPLFVWSIFITAFLLLLSLPVLSAGITMLLLDRNFNTSFFEVSGGGDPILYEHLFWFFGHPEVYILIIPGFGIISHVVSTYSKKPVFGEISMVYAMASIGLLGFLVWSHHMYIVGLDADTRAYFTSATMIIAIPTGIKIFSWLMNPFSKDKNKNKNKKLIRNYQKMNNNNMMKTYLNNNNMIMMNMYKGNLYDIYPRSNRNYIQPNNINKELVVYGYNLESCVGMPTYTNIVKHMVGIPNNILYIMTGILLTDGWIDYTSKKDLDKKTIMEINCRFRLKQSMIHSEYLMYVFMLLSHYCMSYPKMKIAKVKGKSYNQLEFYTRSLPCFTILRYMFYNGRVKIVPNNLYDLLNYESLAHMIMCDGSFVKGGGLYLNLQSFTTKELIFIMNILKIKFNLNCTLHKSRNKYTIYMRVESVKRLFPMIYKYILPSMRYKFDIMLWQKKYNMIN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	AKDIAVLYFMLAIFS HHHHHHHHHHHHHHC	4.75	30377154
25	Phosphorylation	YFMLAIFSGMAGTAM HHHHHHHCCCCHHHH	22.88	30377154
33	Phosphorylation	GMAGTAMSLIIRLEL CCCHHHHHHHHHHHH	17.60	30377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCE4_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCE4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCE4_YEAST !!

Protein-Protein Interaction

Oops, there are no PPI records of SCE4_YEAST !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.