AI2M_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AI2M_YEAST
• UniProt AC: P03876
• Protein Name: Putative COX1/OXI3 intron 2 protein
• Gene Name: AI2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 854
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFCAPFRLIYHCIEVLIDKHISVYSINENFTVSFWFWLLVVTYMVFRYVNHMAYPVGANSTGTMACHKSAGVKQPAQGKNCPMARLTNSCKECLGFSLTPSHLGIVIHAYVLEEEVHELTKNESLALSKSWHLEGCTSSNGKLRNTGLSERGNPGDNGVFMVPKFNLNKVRYFSTLSKLNARKEDSLAYLTKINTTDFSELNKLMENNHNKTETINTRILKLMSDIRMLLIAYNKIKSKKGNMSKGSNNITLDGINISYLNKLSKDINTNMFKFSPVRRVEIPKTSGGFRPLSVGNPREKIVQESMRMMLEIIYNNSFSYYSHGFRPNLSCLTAIIQCKNYMQYCNWFIKVDLNKCFDTIPHNMLINVLNERIKDKGFMDLLYKLLRAGYVDKNNNYHNTTLGIPQGSVVSPILCNIFLDKLDKYLENKFENEFNTGNMSNRGRNPIYNSLSSKIYRCKLLSEKLKLIRLRDHYQRNMGSDKSFKRAYFVRYADDIIIGVMGSHNDCKNILNDINNFLKENLGMSINMDKSVIKHSKEGVSFLGYDVKVTPWEKRPYRMIKKGDNFIRVRHHTSLVVNAPIRSIVMKLNKHGYCSHGILGKPRGVGRLIHEEMKTILMHYLAVGRGIMNYYRLATNFTTLRGRITYILFYSCCLTLARKFKLNTVKKVILKFGKVLVDPHSKVSFSIDDFKIRHKMNMTDSNYTPDEILDRYKYMLPRSLSLFSGICQICGSKHDLEVHHVRTLNNAANKIKDDYLLGRMIKMNRKQITICKTCHFKVHQGKYNGPGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	AKDIAVLYFMLAIFS HHHHHHHHHHHHHHC	4.75	30377154
25	Phosphorylation	YFMLAIFSGMAGTAM HHHHHHHCCCCHHHH	22.88	30377154
33	Phosphorylation	GMAGTAMSLIIRLEL CCCHHHHHHHHHHHH	17.60	30377154
506	Phosphorylation	EFNTGNMSNRGRNPI CCCCCCCCCCCCCCH	27.63	24930733
522	Phosphorylation	NSLSSKIYRCKLLSE HHHHHHHHHHHHHHH	17.44	28889911
591	Phosphorylation	LKENLGMSINMDKSV HHHHCCCCCCCCHHH	14.71	27017623
597	Phosphorylation	MSINMDKSVIKHSKE CCCCCCHHHHHHCCC	25.47	27017623
769	Phosphorylation	MNMTDSNYTPDEILD CCCCCCCCCHHHHHH	24.49	30377154
780	Phosphorylation	EILDRYKYMLPRSLS HHHHHHHHHCHHCHH	8.58	30377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AI2M_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AI2M_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AI2M_YEAST !!

Protein-Protein Interaction

Oops, there are no PPI records of AI2M_YEAST !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-522, AND MASSSPECTROMETRY.
PubMed: 18407956