dbPTM

SCE3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SCE3_YEAST
UniProt AC	P03877
Protein Name	Intron-encoded DNA endonuclease aI3
Gene Name	AI3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	415
Subcellular Localization	Mitochondrion. Membrane Multi-pass membrane protein .
Protein Description	Mitochondrial DNA endonuclease involved in intron homing. It introduces a specific double-strand break in the DNA of the COX1 gene and thus mediates the insertion of an intron, containing its own coding sequence (group I intron), into an intronless gene. Recognizes with high specificity and cleaves the sequence 5'-GGTTTTGGTAACTATTTATTAC-3'..
Protein Sequence	MVQRWLYSTNAKDIAVLYFMLAIFSGMAGTAMSLIIRLELAAPGSQYLHGNSQLFNVLVVGHAVLMIFFLVMPALIGGFGNQKRYESNNNNNQVMENKEYNLKLNYDKLGPYLAGLIEGDGTITVQNSSSMKKSKYRPLIVVVFKLEDLELANYLCNLTKCGKVYKKINRNYVLWTIHDLKGVYTLLNIINGYMRTPKYEAFVRGAEFMNNYINSTTITHNKLKNMDNIKIKPLDTSDIGSNAWLAGMTDADGNFSINLMNGKNRSSRAMPYYCLELRQNYQKNSNNNNINFSYFYIMSAIATYFNVNLYSRERNLNLLVSTNNTYKTYYSYKVMVANTYKNIKVMEYFNKYSLLSSKHLDFLDWSKLVILINNEGQSMKTNGSWELGMNLRKDYNKTRTTFTWSHLKNTYLENK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	AKDIAVLYFMLAIFS HHHHHHHHHHHHHHC	4.75	30377154
25	Phosphorylation	YFMLAIFSGMAGTAM HHHHHHHCCCCHHHH	22.88	30377154
33	Phosphorylation	GMAGTAMSLIIRLEL CCCHHHHHHHHHHHH	17.60	30377154
172	Phosphorylation	YKKINRNYVLWTIHD HHHCCCCEEEEEHHH	8.15	28889911
176	Phosphorylation	NRNYVLWTIHDLKGV CCCEEEEEHHHHCHH	12.31	28889911
348	Phosphorylation	KNIKVMEYFNKYSLL CCEEEHHHHHHHHHH	8.38	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SCE3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SCE3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SCE3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SCE3_YEAST !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SCE3_YEAST

Related Literatures of Post-Translational Modification